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DNA replication licensing factor

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

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Author information

Authors and Affiliations

  1. DNA Replication Control Laboratory, ICRF Clare Hall Laboratories, South Mimms, Herts., EN6 3LD, UK

    James P. J. Chong & J. Julian Blow

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  1. James P. J. Chong
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  2. J. Julian Blow
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer , Silvana Guidet  & Lee Vogel ,  & 

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Chong, J.P.J., Blow, J.J. (1996). DNA replication licensing factor. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-5873-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7693-4

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