Abstract
The pathogenesis of hyperlactatemia during SIRS is poorly understood. Yet lactate is often used clinically as a marker of anaerobic metabolism and is thus assumed to represent inadequate tissue perfusion.1–5 This belief is supported by the high mortality seen in patients with hyperlactatemia,1–2 and by the disordered oxygen transport exhibited by patients with sepsis.6 Many clinicians routinely use therapies to improve global oxygen transport on the assumption that such treatment will reverse tissue dysoxia and ameliorate hyperlactatemia.7–8
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© 1997 Springer Science+Business Media New York
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Kellum, J.A., Kramer, D.J., Mankad, S., Bellomo, R., Lee, K., Pinsky, M.R. (1997). Release of Lactate by the Lung in Acute Lung Injury. In: Nemoto, E.M., et al. Oxygen Transport to Tissue XVIII. Advances in Experimental Medicine and Biology, vol 411. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5865-1_34
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DOI: https://doi.org/10.1007/978-1-4615-5865-1_34
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