Abstract
Inducing a state of tolerance to allergens has been the aim of a number of studies, which were initiated soon after the identification of IgE as the antibody responsible for anaphylactic reactions. The advantages of such an approach are obvious: high selectivity and lack of possibly detrimental interference with other functions of the immune system. Early work on the subject, including the use of allergens coupled to isologous gam-maglobulins (1,2), had shown that IgE immune responses were amenable to tolerance induction in animals. Derivatives of allergens made by coupling with monomethoxy-polyethylene glycol have also demonstrated their capacity to prevent or down-regulate an IgE response (3).
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References
Borel Y, Kilham L, Hyslop V, Borel H. Isologous IgG-induced tolerance to benzyl penicilloyl. Nature 1976; 261: 49–50.
Filion LG, Lee WY & Sehon AH. Suppression of the IgE antibody response to ovalbumin in mice with a conjugate of ovalbumin and isologous gamma-globulins. Cell Immunol 1980; 54: 115–128.
Sehon AH. Suppression of antibody responses by chemically modified antigens. Int Arch Allergy Appl Immunol 1991; 94: 11–20.
Mudde GC, Hansel TT, Reijsen FCV, Osterhoff BF, and Bruijnzeel-Koomen CAFM. IgE: an immuno-globulin specialized in antigen capture? Immunol Today 1990; 11: 440–443.
Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, & Leder P. Active anaphylaxis in IgE-de-ficient mice. Nature 1994; 370: 367–370.
Eichmann K. Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype. Eur J Immunol 1974; 4: 296.
Blaser K, de Weck AL. Regulation of the IgE antibody response by idiotype-anti-idiotype network. Prog Allergy 1982; 32: 203–264.
Watts C and Lanzavecchia A. Suppressive effect of antibody on processing of T cell epitopes. J Exp Med 1993;178:1459–1463.
Hall EP, Gault EA. Regulation of rat IgE responses by immune complexes. Immunology 1987; 61: 415–419.
Poulsen LK, Lundberg L, Sondergaard I, Weeke B. Allergen-containing immune complexes used for im-munotherapy of allergic asthma. Allergy 1988; 44: 132–142.
da Costa PS, de Macedo MS, Perini A. Suppression of mouse IgE response by immune complexes. J Allergy Clin Immunol 1990; 86: 496–502.
Coulie PG & Van Snick J. Enhancement of IgG anti-carrier responses by IgG2 anti-hapten antibodies in mice. Eur J Immunol 1985; 15: 793.
Rajewsky K & Takemori T. Genetics, expression, and function of idiotypes. Ann Rev Immunol 1983; 1: 569–607.
Saint-Remy JMR. Idiotypic network and immediate hypersensitivity. in Idiotypic network and diseases. Eds. Hiernaux J and Cerny J. American Society of Microbiologists, 1990 pp 139–173.
Machiels JJ, Somville MA, Lebrun PM, Jacquemin MG, and Saint-Remy JMR. Allergen-antibody complexes can efficiently prevent seasonal rhinitis and asthma in grass pollen hypersensitive patients. Allergy 1991; 46: 335–348.
Machiels JJ, Somville MA, Lebrun PM, Lebecque SJ, Jacquemin MG, and Saint-Remy JMR. Allergic bronchial asthma due to D. pteronyssinus hypersensitivity can be efficiently treated by inoculation of allergen antibody complexes. J Clin Invest 1990; 85: 1024–1035.
Machiels JJ, Lebrun P, Jacquemin MG, and Saint-Remy JMR. Significant reduction of nonspecific bronchial reactivity in patients with Dermatophagoidespteronyssinus-scnsitive allergic asthma under therapy with allergen-antibody complexes. Am Rev Resp Disease 1993; 147: 1407–1412.
Leroy B, Lachapelle JM, Somville MM, Jacquemin MG, and Saint-Remy JMR. Injection of allergen-antibody complexes is an effective treatment of atopic dermatitis. Dermatologica 1991; 182: 98–106.
Leroy BP, Boden Griet, Lachapelle JM, Jacquemin MG, and Saint-Remy JMR. A novel therapy for atopic dermatitis using antigen-antibody complexes: a double-blind placebo-controlled study. J Am Acad Derma-toll 1993; 28: 232–239.
Jacquemin M, and Saint-Remy JMR. Specific down-regulation of anti-allergen IgE and IgG antibodies in man associated with injections of allergen-specific antibody complexes. Therapeutic Immunol 1995; in press.
Weyer Anne, Le Mao Joelle, Etievant M, David B, Guinnepain Marie-Thérèse, and Saint-Remy JMR. Human auto-anti-idiotypic antibodies to mite-specific IgE can degranulate human basophils in vitro. Clin Exp Allergy 1995; 25: in press.
Platts-Mills TAE. Allergen-specific treatment for asthma: III. Am Rev Respir Dis 1993; 148:553–555.
Daëron M, Malbec O, Latour S, Arock M, Fridman WH. Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 1995; 95: 577–585.
Leroy BP, Jacquemin MG, Lachapelle JM, and Saint-Remy JMR. Allergen-sensitive atopic dermatitis is improved by injections of allergen combined to F(ab’)2 fragments of specific antibodies. Br J Dermatol 1995; 132: in press.
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Saint-Remy, JM.R. (1996). Modulation of Anti-Allergen Immune Responses by Allergen-Antibody Complexes. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_61
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DOI: https://doi.org/10.1007/978-1-4615-5855-2_61
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