Abstract
A combination of accelerated mutation rates and the presence of numerous different cell types in solid tumors creates a degree of stemline and cellular heterogeneity that constitutes a considerable challenge to the flow cytometric analysis of prognostic parameters. While multi-site sampling can circumvent the effect of stemline heterogeneity (2), the solution to the problem of cellular heterogeneity is less straightforward, and has, until relatively recently, been hampered by technological limitations.
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© 1996 Springer Science+Business Media New York
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Bolton, W.E., O’Brien, M. (1996). The Effects of Tumor Heterogeneity on the Flow Cytometric Analysis of Clinical Specimens. In: Kohen, E., Hirschberg, J.G. (eds) Analytical Use of Fluorescent Probes in Oncology. NATO ASI Series, vol 286. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5845-3_17
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DOI: https://doi.org/10.1007/978-1-4615-5845-3_17
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