Role of Angiotensin in Angiogenesis and Cardiac Fibrosis in Heart Failure

  • Suresh C. Tyagi
  • Melvin R. Hayden
  • John E. Hall
Part of the Progress in Experimental Cardiology book series (PREC, volume 2)


Cardiac hypertrophy is associated with the accumulation of extracellular matrix (ECM), cardiac fibrosis, and abnormal diastolic stiffness. Intra-coronary fibrosis in the hyper-trophied myocardium can lead to occlusion of a major coronary artery with resulting ischemia. Angiotensin (Ang) II is associated with cardiac hypertrophy and fibrosis as well as angiogenesis, but the mechanisms are unknown. Tissue levels of angiotensin are elevated in the ischemic and nonischemic regions of the failing heart, and there is evidence that Ang II contributes to myocardial cellular hypertrophy and cardiac fibrosis. Also, Ang II may contribute to angiogenesis in the infarcted heart, thereby increasing collateral circulation. Angiotensin-converting enzyme inhibitor (ACEI) treatment opposes hypertrophy and ischemic heart failure. The mechanisms responsible for this cardioreparative effect of ACEI are largely unknown, but may due to inhibition of Ang II formation as well as other mechanisms. In the infarcted and noninfarcted ischemic heart, interstitial matrix metalloproteinases (MMPs) are activated. Recent experiments suggest that ACEI improves cardiac function and reduces myocardial ischemic damage, in part, by inhibiting MMP activity.


Heart Failure Vascular Endothelial Growth Factor Left Anterior Descend Cardiac Hypertrophy Cardiac Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Suresh C. Tyagi
    • 1
  • Melvin R. Hayden
    • 1
  • John E. Hall
    • 1
  1. 1.Department of Physiology and Biophysics, and Center of Excellence in CardiovascularRenal-Research University of Mississippi Medical CenterJacksonUSA

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