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Role of Angiotensin in Angiogenesis and Cardiac Fibrosis in Heart Failure

  • Suresh C. Tyagi
  • Melvin R. Hayden
  • John E. Hall
Part of the Progress in Experimental Cardiology book series (PREC, volume 2)

Summary

Cardiac hypertrophy is associated with the accumulation of extracellular matrix (ECM), cardiac fibrosis, and abnormal diastolic stiffness. Intra-coronary fibrosis in the hyper-trophied myocardium can lead to occlusion of a major coronary artery with resulting ischemia. Angiotensin (Ang) II is associated with cardiac hypertrophy and fibrosis as well as angiogenesis, but the mechanisms are unknown. Tissue levels of angiotensin are elevated in the ischemic and nonischemic regions of the failing heart, and there is evidence that Ang II contributes to myocardial cellular hypertrophy and cardiac fibrosis. Also, Ang II may contribute to angiogenesis in the infarcted heart, thereby increasing collateral circulation. Angiotensin-converting enzyme inhibitor (ACEI) treatment opposes hypertrophy and ischemic heart failure. The mechanisms responsible for this cardioreparative effect of ACEI are largely unknown, but may due to inhibition of Ang II formation as well as other mechanisms. In the infarcted and noninfarcted ischemic heart, interstitial matrix metalloproteinases (MMPs) are activated. Recent experiments suggest that ACEI improves cardiac function and reduces myocardial ischemic damage, in part, by inhibiting MMP activity.

Keywords

Heart Failure Vascular Endothelial Growth Factor Left Anterior Descend Cardiac Hypertrophy Cardiac Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Daemen MJAP, Lombardi DM, Bosman FT, Schwartz SM. 1991. Angiotensin II induced smooth muscle proliferation in the normal and injured rat arterial wall. Circ Res 68:450–456.PubMedCrossRefGoogle Scholar
  2. 2.
    Paquet JI, Badouin-Legros M, Brunelle G, Meyer P. 1990. Angiotensin II induced proliferation of aortic myocytes in spontaneously hypertensive rats. J Hypertens 8:565–572.PubMedCrossRefGoogle Scholar
  3. 3.
    Stouffer GA, Owens GK. 1992. Angiotensin II induced mitogenesis of spontaneously hypertensive rats-derived smooth muscle cell is dependent on autocrine production of transforming growth factor β1. Circ Res 70:820–828.PubMedCrossRefGoogle Scholar
  4. 4.
    Lindpaintner K, Ganten D. 1991. The cardiac renin-angiotensin system. An appraisal of present experimental and clinical evidence. Circ Res 68:905–921.PubMedCrossRefGoogle Scholar
  5. 5.
    Sadoshima J, Xu Y, Slayter HS, Izumo S. 1993. Autocrine release of angiotensin II mediated stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75:977–984.PubMedCrossRefGoogle Scholar
  6. 6.
    Katwa LC, Tyagi SC, Campbell SE, Lee SJ, Cicila GT, Weber KT. 1996. Valvular interstitial cells express angiotensinogen and cathespsin D, and generate angiotensin peptides. Intn J Biochem Cell Biol 28:807–821.CrossRefGoogle Scholar
  7. 7.
    Sadoshima J, Izumo S. 1993. Molecular characterization of angiotensin II induced hypertrophy of cardiac myocytes and pyperplasia of cardiac fibroblasts, critical role of the angiotensin II receptor subtype. Circ Res 73:413–423.PubMedCrossRefGoogle Scholar
  8. 8.
    Katwa LC, Ratajska A, Cleutjens JPM, Sun Y, Zhou G, Lee SJ, Weber KT. 1995. Angiotensin converting enzyme and kininase II-like activities in cultured valvular interstitial cells of the rat heart. Cardiovas Res 29:57–64.Google Scholar
  9. 9.
    Rivera VM, Greenberg ME. 1990. Growth factor induced gene expression: The ups and downs of c-fos regulation. New Biol 2:751–758.PubMedGoogle Scholar
  10. 10.
    Weber KT, Sun Y, Tyagi SC, Cleutjens J. 1994. Collagen network of the myocardium: Function, structural remodeling and regulatory mechanisms. J Mol Cell Cardiol 26:279–292.PubMedCrossRefGoogle Scholar
  11. 11.
    Weber KT, Sun Y, Guarda E, Zhou G, Ratajska A, Tyagi SC. 1994. Myocardial Fibrosis: Regulatory mechanisms and potential interventions. International Society of Hypertension, Hypertension Annual Reviews 128–137.Google Scholar
  12. 12.
    McKee PA, Castelli WP, McNamara PM, Kannel WB. 1971. The natural history of congestive heart failure; the Framingham study. N Eng J Med 285:1441–1446.CrossRefGoogle Scholar
  13. 13.
    Caird FI, Kennedy RD. 1976. Epidemiology of heart disease in old age. In Cardiology in old age. Ed. FI Caird, JLC Dali, RD Kennedy, 1–10. New York: NY Plenum Publishing.CrossRefGoogle Scholar
  14. 14.
    Pfeffer JM, Pfeffer MA, Fishbein MC, Frohlich ED. 1979. Cardiac Function and morphology with aging in the spontaneously hypertensive rat. Am J Physiol 237:H461–H468.PubMedGoogle Scholar
  15. 15.
    Conrad CH, Brooks WW, Robinson KG, Bing OHL. 1991. Impaired myocardial function in spontaneously hypertensive rats with heart failure. Am J Physiol 260:H136–H145.PubMedGoogle Scholar
  16. 16.
    Tyagi SC, Bheemanathini VS, Mandi S, Reddy HK, Voelker DJ. 1996. Role of extracellular matrix metalloproteinases in cardiac remodeling. Heart Failure Reviews 1:73–80.CrossRefGoogle Scholar
  17. 17.
    Grossman W. 1980. Cardiac hypertrophy: Useful adaptation or pathological process? Am J Med 69:576–584.PubMedCrossRefGoogle Scholar
  18. 18.
    Brilla CG, Janicki JS, Weber KT. 1991. Impaired diastolic function and coronary reserve in genetic hypertension: Role of interistitial fibrosis and medial thicking of intramyocardial coronary arteries. Circ Res 69:107–115.PubMedCrossRefGoogle Scholar
  19. 19.
    Thiedemann KU, Holubarsch C, Medugorac I, Jacob R. 1983. Connective tissue content and myocardial stiffness in pressure overload hypertrophy: A combined study of morphologic, morpho-metric, biochemical and mechanical parameters. Basic Res Cardiol 78:140–155.PubMedCrossRefGoogle Scholar
  20. 20.
    Narayan S, Janicki JS, Shroff SG, Pick R, Weber KT. 1989. Myocardial collagen and mechanics after preventing hypertrophy in hypertensive rats. Am J Hypertens 2:675–682.PubMedCrossRefGoogle Scholar
  21. 21.
    Doering CW, Jalil JE, Janicki JS, Pick R, Aghili S, Abrahams C, Weber KT. 1988. Collagen network remodeling and diastolic stiffness of the rat LV with pressure overload hypettrophy. Cardiovasc Res 22:686–695.PubMedCrossRefGoogle Scholar
  22. 22.
    Jalil JE, Doering CW, Janicki JS, Pick R, Clark WA, Weber KT. 1988. Structural vs contractile protein remodeling and myocardial stiffness in hypertrophied rat LV. J Mol Cell Cardiol 20:1179–1187.PubMedCrossRefGoogle Scholar
  23. 23.
    Jalil JE, Janicki JS, Pick R, Weber KT. 1991. Coronary vascular remodeling and myocardial fibrosis in the rat with renovascular hypertension: Response to captopril. Am J Hypertens 4:51–55.PubMedGoogle Scholar
  24. 24.
    Jalil JE, Doering CW, Janicki JS, Pick R, Shroff SG, Weber KT. 1989. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat LV. Circ Res 64:1041–1050.PubMedCrossRefGoogle Scholar
  25. 25.
    Zhou G, Kandala JC, Tyagi SC, Katwa LC, Weber KT. 1996. Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts. Mol Cell Biochem 154:171–178.PubMedCrossRefGoogle Scholar
  26. 26.
    Reddy HK, Sigusch H, Zhou G, Tyagi SC, Janicki JS, Weber KT. 1995. Coronary Vascular Hyperpermeability and agiotensin II. J Lab Clin Med 126:307–315.PubMedGoogle Scholar
  27. 27.
    Hall JE. 1991. Renal function in one kidney, one clip hypertension and low renin essential hypertension. Am J Hyper 4:523S–533S.Google Scholar
  28. 28.
    Wahlander H, Isgaard J, Jennische E, Friberg P. 1992. Left ventricular insulin-like growth factor I increases in early renal hypertension. Hyperten 19:25–32.CrossRefGoogle Scholar
  29. 29.
    Ghahary A, Shen VJ, Nedelec B, Scott PG, Tredget EE. 1995. Enhanced expression of mRNA for insulin-like growth factor-1 in post-burn hypettrophic scar tissue and its fibrogenic role by dermal fibroblasts. Mol Cell Biochem 148:25–32.PubMedCrossRefGoogle Scholar
  30. 30.
    Folkman J, Warson K, Inger D, Hanahan D. 1989. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339:58–61.PubMedCrossRefGoogle Scholar
  31. 31.
    Vernon R, Sage EH. 1995. Between molecules and morphology: extracellular matrix and creation of vascular form. Am J Pathol 147:873–883.PubMedGoogle Scholar
  32. 32.
    Risau W, Ekblom P. 1986. Growth factors and the embryonic kidney. In Progress in clinical and biological research, hormonal control of embryonic and cellular differentation. Ed. D Serrero. New York: Liss.Google Scholar
  33. 33.
    Schaper W. 1991. Angiogenesis in the adult heart. Bas Res Cardiol 86:51–56.Google Scholar
  34. 34.
    Pasyk S, Flameng W, Wusten B, Schaper W. 1976. Influence of tachycardia on regional myocardial flow in chronic experimental coronary occlusion. Bas Res Cardiol 71:243–251.CrossRefGoogle Scholar
  35. 35.
    Tyagi SC, Kumar SG, Cassatt S, Parker JL. 1996. Temporal expression of extracellular matrix metalloproteinase and tissue plasminogen activator in the development of collateral vessels in canine model of coronary occlusion. Canad J Physiol & Pharmacol 74:983–995.Google Scholar
  36. 36.
    Gondo M, Maruta H, Arakawa K. 1989. Direct formation of agiotensin II without renin or converting enzyme in the ischemic dog heart. Jpn Heart J 30:219–229.PubMedCrossRefGoogle Scholar
  37. 37.
    Fernandez LA, Caride VJ, Twickler J, Galardy RE. 1982. Renin-angiotensin and development of collateral circulation after renal ischemia. Am J Physiol 243:H869–H875.PubMedGoogle Scholar
  38. 38.
    Le Noble FAC, Schreurs JS, VanStraaten HWM, Slaaf DW, Smits JFM, Rogg H, Struijker-Boudier AJ. 1993. Evidence for a novel angiotensin II receptor involved in angiogenesis in chick embryo chorioallantoic membrane. Am J Physiol 264:R460–R465.PubMedGoogle Scholar
  39. 39.
    Puri PL, Avantaggiati L, Burgio VL, Chirillo P, Collepardo D, Natoli G, Balsano C, Leverero M. 1995. Reactive oxygen intermediates are involved in the intracellular transduction of angiotenin II signal in C2C12 cells. Ann N Y Acad Sci 752:395–405.CrossRefGoogle Scholar
  40. 40.
    Iruela-Arispe ML, Diglio CA, Sage EH. 1991. Modulation of extracellular matrix proteins by endothelial cells undergoing angiogenesis in vitro. Arterioscl Thromb 11:805–815.PubMedCrossRefGoogle Scholar
  41. 41.
    Montesano R, Vassalli JD, Baird A, Guillemin A, Orci L. 1986. Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci (USA) 83:7297–7301.CrossRefGoogle Scholar
  42. 42.
    Plate KH, Breier G, Weich HA, Risau W. 1992. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vitro. Nature 359:845–848.PubMedCrossRefGoogle Scholar
  43. 43.
    Shweiki D, Itin A, Soffer D, Keshet E. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843–844.PubMedCrossRefGoogle Scholar
  44. 44.
    Ladoux A, Frelin C. 1993. Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Biochem Biophys Res Commun 195:1005–1010.PubMedCrossRefGoogle Scholar
  45. 45.
    Asahara T, Bauters C, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM. 1995. Synergistic effect of VEGF and bFGF on angiogenesis in vivo. Circulation 92:11365–11371.CrossRefGoogle Scholar
  46. 46.
    Huckle WR, Earp HS. 1994. Regulation of cell proliferation and growth by angiotensin II. Prog Growth Fact Res 5:177–194.CrossRefGoogle Scholar
  47. 47.
    Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner RA, Braunwald E. 1979. Myocardial infarct size and ventricular function in rats. Cir Res 44:503–512.CrossRefGoogle Scholar
  48. 48.
    Pfeffer MA, Pfeffer JM, Fletcher PJ, Braunwald E. 1991. Progressive ventricular remodeling in rat with myocardial infarction. Am J Physiol 260(Heart Circ Physiol 29):H1406–H1414.PubMedGoogle Scholar
  49. 49.
    Springer TA. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301–314.PubMedCrossRefGoogle Scholar
  50. 50.
    Takahashi S, Barry AC, Factor SM. 1990. Collagen degradation in ischemic rat hearts. Biochem J 265:233–241.PubMedGoogle Scholar
  51. 51.
    Tyagi SC, Kumar SG, Alla SR, Reddy HK, Voelker DJ, Janicki JS. 1996. Extracellular matrix regulation of metalloproteinase and antiproteinase in human heart fibroblast cells. J Cell Physiol 167:137–147.PubMedCrossRefGoogle Scholar
  52. 52.
    Pfeffer MA, Braunwald E. 1990. Ventricular remodeling after myocardial infarction: experimental observations and clinical implications. Circulation 81:1161–1172.PubMedCrossRefGoogle Scholar
  53. 53.
    Kolocassides KG, Galinanes M, Hearse DJ. 1996. Dichotomy of ischemic preconditioning. Circulation 93:1725–1733.PubMedCrossRefGoogle Scholar
  54. 54.
    Olivetti G, Capasso JM, Sonnenblick EH, Anversa P. 1990. Side-to side slippage of myocytes participates in ventricular wall remodeling acurely after myocardial infarction in rats. Cir Res 67:23–34.CrossRefGoogle Scholar
  55. 55.
    Capasso JM, Zhang PL, Meggs LG, Anversa P. 1993. Alterations in ANG II responsiveness in LV and RV after infarction-induced heart failure, Am J Physiol 264(Heart Cir Physiol 33):H2056–H2067.PubMedGoogle Scholar
  56. 56.
    Saks VA, Belikova YO, Kuznetsov AV, Khuchua ZA, Branishte TH, Semenovsky ML, Naumov VG. 1991. Phosphocreatine pathway for energy transport: ADP diffusion and cardiomyopathy. Am J Physiol 261:30–38.PubMedGoogle Scholar
  57. 57.
    Grossman W, Jones D, McLaurin LP. 1975. Wall stress and patterns of hypertropgy in the human left ventricle. J Clin Invest 56:56–64.PubMedCrossRefGoogle Scholar
  58. 58.
    Hosenpud JD. 1994. The cardiomyopathies. In Congestive heart failure, pathophysiology, diagnosis and comprehensive approach to management. Ed. JD Hosenpud and BH Greenberg, 196–222. New York: Springer-Verlag.CrossRefGoogle Scholar
  59. 59.
    Manolio TA, Baughman KL, Rodeheffer R, Pearson TA, Bristow JD, Michels W, Abelmann WH, Harlan WR. 1992. Prevalence and etiology of idiopathic dilated cardiomyopathy (Summary of a Natlonal Heart, Lung and Blood Institute Workshop). Am J Cardiol 69:1458–1466.PubMedCrossRefGoogle Scholar
  60. 60.
    WHO-ISFC. 1980. Task force Report on the WHO/ISFC task force on the definition and classification of cardiomyopathies. Br Heart J 44:672–673.CrossRefGoogle Scholar
  61. 61.
    Morgan HE, Baker KM. 1991. Cardiac hypertrophy: Mechanical, neural and endocrine dependence. Circulation 83:13–25.PubMedCrossRefGoogle Scholar
  62. 62.
    Watson PA. 1991. Function follows form: Generation of intracellular signals by cell deformation. FASEB J 5:2013–2019.PubMedGoogle Scholar
  63. 63.
    Borg TK, Burgess ML. 1993. Holding it all together: Organization and function(s) of the extracellular matrix of the heart. Heart Failure 8:230–238.Google Scholar
  64. 64.
    Tyagi SC, Kumar SG, Haas SJ, Reddy HK, Voelker DJ, Hayden MR, Demmy TL, Schmaltz RA, Curtis JJ. 1996. Post-transcriptional regulation of matrix metalloproteinase in human heart end-stage failure secondary to ischemic cardiomyopathy. J Mol Cell Cardiol 28:1415–1428.PubMedCrossRefGoogle Scholar
  65. 65.
    Tyagi SC, Ratajska A, Weber KT. 1993. Myocardial matrix metalloproteinases: Localization and activation. Mol Cell Biochem 126:49–59.PubMedCrossRefGoogle Scholar
  66. 66.
    Tyagi SC, Campbell SE, Reddy HK, Tjahja E, Voelker DJ. 1996. Matrix metalloproteinase activity expression in infarcted, noninfarcted and dilated cardiomyopathic human hearts. Mol Cell Biochem 155:13–21.PubMedCrossRefGoogle Scholar
  67. 67.
    Kannel WB, Belanger AJ. 1991. Epidemiology in heart failure. Am Heart J 121:951–957.PubMedCrossRefGoogle Scholar
  68. 68.
    Ho KKL, Anderson KM, Kannel WB, Grossmann W, Levy D. 1993. Survival after onset of congestive heart failure in Framingham Heart Study subjects. Circulation 88:107–115.PubMedCrossRefGoogle Scholar
  69. 69.
    The consensus trial study group. 1987. Effects of enalapril on mortality in severe congestive heart failure: Results of the cooperative north Scandinavian enalapril study. N Eng J Med 316:1429–1435.CrossRefGoogle Scholar
  70. 70.
    Cohn JN, Johnson G, Ziesche S, Cobb FR, Francis G, Tristani F, Smith R, Dunkman WB, Loeb H, Wong M, Bhat G, Goldman S, Fletcher RD, Doherty J, Hughes CV, Carson P, Cintron G, Shabetau R, Haakenson C. 1991. A comparsion of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Eng J Med 325:303–310.CrossRefGoogle Scholar
  71. 71.
    The SOLVE Investigators. 1991. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Eng J Med 325:293–302.CrossRefGoogle Scholar
  72. 72.
    Pfeffer A, Braunwald E, Moyer LA. 1992. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Eng J Med 327:669–677.CrossRefGoogle Scholar
  73. 73.
    Freeman GL, Little WC, Haywood JR. 1987. Reduction of LV mass in normal rats by captopril. Cardiovasc Res 21:323–327.PubMedCrossRefGoogle Scholar
  74. 74.
    Laher MS, Natln D, Rao SK, Jones RW, Corr P. 1987. Lisinopril in elderly patients with hypertension. J Cardiovasc Pharmacol 9(Suppl 3):69–71.CrossRefGoogle Scholar
  75. 75.
    Himeno H, Crawford DC, Hosoi M, Chobanian AV, Brecher P. 1994. Angitensin II alters aortic fibronectin independently of hypertension. Hypertension 23:823–826.PubMedCrossRefGoogle Scholar
  76. 76.
    Richer C, Mulder P, Fornes P, Richard V, Camilleri JP, Giudicelli JF. 1991. Hemodynamic and morphological effects of quinapril during genetic hypertension development. J Cardiovasc Pharmacol 18:631–642.PubMedCrossRefGoogle Scholar
  77. 77.
    Diez J, Panizo A, Gil MJ, Monreal I, Hernandez M, Mindan JP. 1996. Serum markers of collagen I metabolism in spontaneously hypertensive rats. Circulation 93:1026–1032.PubMedCrossRefGoogle Scholar
  78. 78.
    Tyagi SC, Kumar SG, Banks J, Fortson W. 1995. Co-expression of tissue inhibitor and matrix metalloproteinase in myocardium. J Mol Cell Cardiol 27:2177–2189.PubMedCrossRefGoogle Scholar
  79. 79.
    Nikkari ST, O’Brien KD, Ferguson M, Hatsukami T, Welgus HG, Alpers CE, Clowes AW. 1995. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis. Cir Res 92:1393–1398.Google Scholar
  80. 80.
    Armstrong PW, Moe GW, Howard RJ, Grima EA, Cruz TF. 1994. Structural remodeling in heart failure: Gelatinase induction. Canad J Cardiol 10:214–220.Google Scholar
  81. 81.
    Senger DR. 1996. Molecular framework for angiogenesis: A complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines. Am J Pathol 149:1–7.PubMedGoogle Scholar
  82. 82.
    Tyagi SC, Matsubara L, Weber KT. 1993. Direct extraction and estimation of collagenase(s) activity by zymography in microquantities of rat myocardium and uterus. Clin Biochem 26:191–198.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Suresh C. Tyagi
    • 1
  • Melvin R. Hayden
    • 1
  • John E. Hall
    • 1
  1. 1.Department of Physiology and Biophysics, and Center of Excellence in CardiovascularRenal-Research University of Mississippi Medical CenterJacksonUSA

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