Developmental Regulatlon of the Cardiac Renin-Angiotensin System: Expression and Associatlon With Growth and Apoptosis

  • David E. Dostal
  • Rachel A. Hunt
  • Chris E. Kule
  • Kenneth M. Baker
Part of the Progress in Experimental Cardiology book series (PREC, volume 2)


Identification and elucidation of the roles of humoral factors involved in cardiogenesis and other aspects of cardiac growth will be important for the overall understanding of how the heart develops and functions. Angiotensin (Ang) II has been demonstrated to have important in vivo and in vitro growth-related effects in the neonate and adult myocardium. However, very little is known regarding the regulation of the cardiac renin-angiotensin system (RAS) and the role of Ang II receptors at any developmental stage. Enhanced expression of RAS during fetal and neonatal development suggests that locally produced Ang II exerts autocrine and paracrine influences on cardiogenesis and cardiac growth in these stages of development. Utilization of transgenic models and specific nonpeptide Ang II receptor antagonists will be useful in determining the roles of AT1 and AT2 receptors, respectively, in the regulation of the cardiac RAS, myocardial growth, and apoptosis in the developing rat heart. These studies may provide a better understanding of the effects of Ang II receptors on cellular and molecular aspects of cardiac development and thus lead to improved therapeutic interventions for cardiovascular disease.


Cardiac Hypertrophy Cardiac Fibroblast Cardiac Growth Angiotensin Blockade Human Cardiac Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • David E. Dostal
    • 1
  • Rachel A. Hunt
    • 1
  • Chris E. Kule
    • 1
  • Kenneth M. Baker
    • 1
  1. 1.Weis Center for ResearchGeisinger ClinicDanvilleUSA

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