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Cardiac Angiotensin II Subtype 2 Receptor Signal Transduction Pathways: Embryonic Cardiomyocytes and Human Heart

  • Chapter
Angiotensin II Receptor Blockade Physiological and Clinical Implications

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 2))

Summary

The distribution of the Ang II-receptor subtype 2 (AT2-R) in the heart of various species from chick embryo to neonatal rat, adult rat, rabbit and man is reviewed. Human heart has a predominance of AT2-R while rat and rabbit have considerably less receptors suggesting caution in the extrapolation of data from species with few AT2-R to human. AT2-R signaling mechanisms in the heart utilize phosphoinositol hydrolysis, PKC activation, tyrosine kinase activation and likely PI 3 kinase activation as well. In contrast to AT1-R, the AT2-R is not linked with cAMP signaling. The development of cardiac hypertrophy and subsequent heart failure is associated with alterations of AT2-R density and undoubtedly a disturbance of the usual mechanisms whereby the effect of angiotensin on the heart is manifested.

“It has been concluded that most of the well-known actions of Ang II are mediated by the AT1-receptor subtype” Timmermans et al. [1].

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  1. Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    Simon W. Rabkin

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  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.) (Distinguished Professor and Director MRC Group in Experimental Cardiology), Peter Zahradka Ph.D. (Associate Professor), Ian M. C. Dixon Ph.D. (Assistant Professor) & Robert E. Beamish M.D. (Professor Emeritus) (Distinguished Professor and Director MRC Group in Experimental Cardiology),  (Associate Professor),  (Assistant Professor) &  (Professor Emeritus)

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Rabkin, S.W. (1998). Cardiac Angiotensin II Subtype 2 Receptor Signal Transduction Pathways: Embryonic Cardiomyocytes and Human Heart. In: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (eds) Angiotensin II Receptor Blockade Physiological and Clinical Implications. Progress in Experimental Cardiology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5743-2_27

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