Angiotensin Receptor Antagonists and Cardiovascular Remodeling

  • K. Sabri
  • C. Chassagne
  • B. Lévy
  • J.L. Samuel
  • L. Rappaport
Part of the Progress in Experimental Cardiology book series (PREC, volume 2)


Angiotensin (Ang) II is one of the key hormones involved in cardiovascular homeostasis. It has potent vasoconstrictor effects and is directly involved in the vascular and cardiac remodeling observed in response to chronic or acute hypertension. Two major Ang II receptor subtypes, AT1 and AT2, have been described, and their roles in vivo and in vitro have now been investigated using nonpeptidic antagonists, losartan and PD123319, which block AT1 and AT2 receptors respectively. The aim of this review is to focus on in vivo data to better define the respective functions of the AT1 and AT2 receptor subtypes. In adult rats, the AT1 receptor subtype does not trigger trophic effects directly in cardiomyocytes, whereas the AT2 receptor may have a major trophic role in smooth muscle cells.


Cardiac Hypertrophy Medial Hypertrophy Cardiovascular Remodel Smooth Muscle Cell Phenotype Angiotensin Blockade 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • K. Sabri
    • 1
  • C. Chassagne
    • 1
  • B. Lévy
    • 1
  • J.L. Samuel
    • 1
  • L. Rappaport
    • 1
  1. 1.INSERM U 127, INSERM U141, IFR CirculationUniversité D. DiderotFrance

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