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Importance of Calcium Phosphates in the Development of Calcium Urolithiasis

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Calcium Phosphates in Biological and Industrial Systems

Abstract

Calcium oxalate (CaOx) and calcium phosphate (CaP) are the two most common crystalline constituents of urinary stones and CaOx is their major component.1–9 Appropriate urinary supersaturation is necessary for crystallization. But mammalian urine is normally insufficiently supersaturated for homogeneous nucleation of CaOx. As a result, suggestions have been made that some urinary elements such as macromolecules or crystals act as the substrate for heterogeneous nucleation of CaOx. CaP is often considered a promoter of CaOx crystallization in the urine because, A. it is common in both urine and urinary stones, B. it frequently occurs together with calcium oxalate (CaOx), C. it is occasionally present at the nidus of CaOx-CaP stones, and D. it can support nucleation of CaOx in vitro. The possibility of CaP nucleating CaOx crystals and promoting the formation of CaOx stones will be explored in this chapter.

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Authors and Affiliations

  1. Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA

    Saeed R. Khan

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  1. The Advanced Technology Group, The BFGoodrich Company, 9921 Brecksville Road, Brecksville, Ohio, 44141, USA

    Zahid Amjad Ph.D.

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Khan, S.R. (1998). Importance of Calcium Phosphates in the Development of Calcium Urolithiasis. In: Amjad, Z. (eds) Calcium Phosphates in Biological and Industrial Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5517-9_11

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  • DOI: https://doi.org/10.1007/978-1-4615-5517-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7521-0

  • Online ISBN: 978-1-4615-5517-9

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