Abstract
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• The replication of DNA is semiconservative, involving a single origin of replication in prokaryotes and multiple origins of replication in eukaryotes.
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• Synthesis of new DNA occurs by copying an existing template through the addition of 5′-nucleoside monophosphate units to the 3′OH moiety of a primer sequence.
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• Many proteins are involved in the replication process, and the enzymatic activities are the same in prokaryotes and eukaryotes.
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• The high fidelity of DNA replication is the result of several different postreplicative editing activities that remove errors.
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• Any single DNA segment is usually replicated only once per cell cycle, and the assembly of chromatin after DNA replication in eukaryotes is a critical period for competition between transcription-control factors and histones.
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• Developmentally regulated deviations from the “once only per cell cycle” rule for DNA replication can lead to amplification of regions of the genome.
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Appels, R., Morris, R., Gill, B.S., May, C.E. (1998). Replication of Protosomes and Chromosomes. In: Chromosome Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5409-7_18
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