Abstract
It is now well established that embryonic dopamine cells can survive transplantation into the brains of adult rats and monkeys. If selective toxins (such as 6-OHDA or MPTP), are used to make selective dopamine-depleting lesions, the transplants can provide a new dopaminergic reinnervation of the lesioned striatum, and overcome some of the motor deficits induced by the lesions in the host animals (9). Based on such experimental observations, a number of neurosurgical centres have undertaken clinical trials of similar procedures in patients with Parkinson’s disease, with a clear and demonstrable clinical benefit in a number of cases (19,25).
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Dunnett, S.B., Annett, L.E., Kendall, A.L., Rosser, A.E., Watts, C., Svendsen, C.N. (1997). Sources of Cells for Transplantation and Gene Therapy in Parkinson’s Disease. In: Teelken, A., Korf, J. (eds) Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5405-9_42
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DOI: https://doi.org/10.1007/978-1-4615-5405-9_42
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