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Neurochemistry pp 193–196Cite as

The Role of Noradrenaline in Depression and its Therapy

A Reappraisal of Its Importance

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Abstract

The symptoms of depression are related to a decreased content and/or activity of cerebral monoamines, catecholamines, particularly noradrenaline (NA) (1, 2) and serotonin (5-hydroxytryptamine, 5-HT) (3). Over the last 4 decades, the order of assumed importance of the roles of NA and 5-HT has tended to follow an evolution from “exclusively NA” via “NA and possibly 5-HT”, “NA and 5-HT”, “5-HT and possibly NA” to finally “exclusively 5-HT”. We will examine here to what extent this evolution is justified and attempt to evaluate the role for NA in antidepressant therapy.

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Author information

Authors and Affiliations

  1. Pierre Fabre Research Centre, Castres, France

    Mike Briley & Chantal Moret

Authors
  1. Mike Briley
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  2. Chantal Moret
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Editor information

Editors and Affiliations

  1. University Hospital, Groningen, The Netherlands

    Albert Teelken  & Jaap Korf  & 

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© 1997 Springer Science+Business Media New York

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Briley, M., Moret, C. (1997). The Role of Noradrenaline in Depression and its Therapy. In: Teelken, A., Korf, J. (eds) Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5405-9_32

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  • DOI: https://doi.org/10.1007/978-1-4615-5405-9_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7468-8

  • Online ISBN: 978-1-4615-5405-9

  • eBook Packages: Springer Book Archive

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