Abstract
Many phenomena of short term adaptations of the CNS have been explained with changes in the conductance of ion channels, that are induced by cascades of second transmitter systems ultimately leading towards ion channel phosphorylation. On the other hand, it is the long-term consolidation of memory that appears to be vulnerable, in particular in the context of age-related disseases of which Alzheimer’s is but the most prominent example. A few years ago, cell adhesion molecules were considered just sticky agglutinants, but now it is well accepted that they are accurately regulated glycoproteins involved in li- gand-receptor relationships triggering intracellular second messenger cascades. They are known to guide axonal growth and the migration of neurectodermal cells during epige- netic differentiation. Also during CNS regeneration cell adhesion molecules are involved.
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Schmidt, R. (1997). Regulated Expression of the CNS-Specific Cell Adhesion Molecule Ependymin After Acquisition of an Active Avoidance Behaviour Provides a Possible Mechanism for Memory Consolidation. In: Teelken, A., Korf, J. (eds) Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5405-9_143
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