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Impaired Hemorheology in the Aged Associated with Oxidative Stress

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Book cover Oxygen Transport to Tissue XIX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 428))

Abstract

Oxygen transport to the tissues depends on the ability of blood cells to flow through the circulatory system. The flow of blood in the circulatory network depends upon many factors. The viscosity which measures the resistance to flow is a major factor in determining the hemorheological properties of blood. A number of studies (Torre la de et al.; 1993, Paul et al., 1996; Sharp et al., 1996) indicate that the hemorheological properties, which determine blood flow, are impaired in the aged. Thus, aging has been shown to be associ ated with an increase in fibrinogen, plasma viscosity, whole blood viscosity and whole blood filterability (Avellone et al., 1993, Lechner et al., 1987).

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References

  • Abugo O., Rifkind J.M. Oxidation of hemoglobin and the enhancement produced by Nitroblue Tetrazolium. Jour nal of Biochemistry; 269: 24845–24853, 1994.

    CAS  Google Scholar 

  • Araki K, Rifkind J.M. Age dependent changes in osmotic hemolysis of human erythrocytes. Journal of Gerontol ogy. 35; 499–505, 1980.

    Article  CAS  Google Scholar 

  • Avellone G, Garbo D, Panno AV, R Cordova, Alletto G, Raneli G, De Simone R, Strano A, Bompani GD. Haemor-heological components in the pre-geriatric and geriatric age range in a randomly selected western Sicily population sample (Casteldaccia Study). Clinical Hemorheology 13: 83–92. 1993.

    Google Scholar 

  • Balagopalkrishnan C, Manoharan P. T., Abugo O. O., Rifkind J.M. Production of Superoxide from hemoglobin-bound oxygen under hypoxic conditions. Biochemistry; 35: 6393–6398, 1996.

    Article  Google Scholar 

  • Barasch E, Benderly M, Graff E, Behar S, Reicher-Reiss H., Caspi A, Pelled B, Reisin L, Roguin N, Goldbourt U. Plasma fibrinogen levels and their correlate in 6457 coronary heart diseases patients. The Bezaflbrate In farction Prevention (BIP) study. J Clin Epidemiol. 48: 757–765, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Bauer K.A., Weiss L. M., Sparrow D., Vokonas P.S., Rosenberg R.D. Aging associated changes in indices of thrombin generation and protein C activation in humans. Normative aging study. Journal of Clinical Inves tigation; 80: 1527–1534, 1987.

    Article  CAS  Google Scholar 

  • Hager K, Felicetti M, Seefrid G, Platt D. Fibrinogen and aging. Aging Clinical Exp Res. 6:133–138, 1994.

    CAS  Google Scholar 

  • Helman N, Lawrence S. The effects of age, sex and smoking on erythrocytes and leukocytes. American Journal of Cardiology; 63: 35–44, 1975.

    CAS  Google Scholar 

  • Jain S. K. Hyperglycemia can cause membranes lipid peroxidation and osmotic fragility in human red blood cells. Journal of Biochemistry; 264:21340–21345, 1989.

    CAS  Google Scholar 

  • Lechner H, Ott E, Schmidt R: Present state of hemorheology. Gerontology, 33:259–264, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Misra H.P., Fridovich I. The generation of Superoxide radical during the autoxidation of hemoglobin. Journal of Biological Chemistry; 247: 6960–6962, 1972.

    PubMed  CAS  Google Scholar 

  • Paul SD, O’Gara PT, Mahjoub ZA, DiSalvo TG, O’Donnell CJ, Newell JB, Levy GV, Smith AJC, Kondo NI, Cararach M, Ferrer L, Eagle KA. Geriatric patients with acute myocardial infarction: Cardiac risk profiles, presentation, thrombolysis, coronary interventions and prognosis. American Heart Journal. 131: 710–715, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Pierrefiche G, Laborit H. Oxygen free radicals, melatonin and, aging. Experimental Gerontology; 30: 213–227, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Rifkind J.M., Zhang L., Heim J.M., Levy A. The role of hemoglobin in generating oxyradicals. Oxygen Radicals in Biology and Medicine, 157–162, 1989.

    Google Scholar 

  • Rifkind J. M., Zhang L., Levy A., Manoharan P.T. The hypoxic stress on erythrocytes associated with Superoxide formation. Free Radical research Communication. 12-13:645–652, 1991.

    Article  CAS  Google Scholar 

  • Rifkind J. M., Abugo O., Levy A., Monticone R., Heim J. Formation of free radicals under hypoxia. In: Surviving Hypoxia: Mechanism of control and adaptation (ed: Hochachka PW, Lutz PL, Sick T, Rosenthal M, Thil-lart G. Van den) CRC Press. 1992:510–521.

    Google Scholar 

  • Rifkind J.M., Abugo O. Alteration in erythrocyte deformability under hypoxia: implication for impaired oxygen ransport. Oxygen Transport to Tissue XVI, 345–351, 1994.

    Google Scholar 

  • Rose H.G, Okleander M. Improved procedure for the extraction of lipids from human erythrocytes. Journal of Lipid Research; 6: 428–431, 1965.

    PubMed  CAS  Google Scholar 

  • Sharp DS, Abbott RD, Burchifel CM, Rodriguez BL, Tracy RP, Yano K, Curb DJ. Plasma fibrinogen and coronary heart disease in elderly Japanese-American men. Aretrioscler Thromb Vase Biol. 16: 262–268, 1996.

    Article  CAS  Google Scholar 

  • Shirakura T, Kubota K, Tamura K. Blood viscosity and cerebral blood flow. Jpn J Geriat. 30: 174–181, 1993.

    Article  CAS  Google Scholar 

  • Snyder L.M., Fortier N.L., Trainor J., Jacobs J., Leb L., Dubin D., Shohet S., Moandas N. Effect of hydrogen per-oxide on erythrocyte membrane cross linking. Journal of Clinical Investigation; 76:1971–1977, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Torre la de J., Mussivand T: Can disturbed brain microcirculation cause Alzheimer’s disease?. Neruol Res. 15:146–153, 1993.

    Google Scholar 

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© 1997 Springer Science+Business Media New York

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Rifkind, J.M., Ajmani, R.S., Heim, J. (1997). Impaired Hemorheology in the Aged Associated with Oxidative Stress. In: Harrison, D.K., Delpy, D.T. (eds) Oxygen Transport to Tissue XIX. Advances in Experimental Medicine and Biology, vol 428. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5399-1_2

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  • DOI: https://doi.org/10.1007/978-1-4615-5399-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7465-7

  • Online ISBN: 978-1-4615-5399-1

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