Abstract
The plasminogen/plasminogen activator system is but one of many zymogen activation cascades that amplify catalytic processes. The enzyme produced in this system, plasmin, plays the central role in fibrinolysis and is a significant component of other proteolytic events in both health and disease, e.g. embryonic development and extracellular matrix degradation. Plasmin activity can be inhibited by the serpin α2-antiplasmin, while the plasminogen activators, tissue type (tPA) and urokinase (uPA), are also inactivated by serpins: plasminogen activator inhibitors types 1 and 2 (PAI-1 and PAI-2).
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© 1997 Springer Science+Business Media New York
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Andrews, J.L. (1997). Fibrinolysis, Development, and Reproduction. In: Church, F.C., Cunningham, D.D., Ginsburg, D., Hoffman, M., Stone, S.R., Tollefsen, D.M. (eds) Chemistry and Biology of Serpins. Advances in Experimental Medicine and Biology, vol 425. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5391-5_24
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DOI: https://doi.org/10.1007/978-1-4615-5391-5_24
Publisher Name: Springer, Boston, MA
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