Role of Glycan Processing in Hepatitis B Virus Envelope Protein Trafficking

  • Timothy M. Block
  • Xuanyong Lu
  • Anand Mehta
  • Jason Park
  • Baruch S. Blumberg
  • Raymond Dwek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 435)


We have previously shown that the glucosidase inhibitor, NBDNJ, prevents HBV virion but not subviral particle secretion from stably transfected HepG2 cells (Block et al, 1994). Moreover, the inhibition of virion secretion was due to the inhibition of the ER glucosidase (Lu et al, 1995). To determine which envelope protein functions require glycan processing and to understand the consequences to a glycoprotein of bearing unprocessed glycan, it was of interest to know the specific steps in the virus life cycle which were upset in cells in which ER glucosidase was inhibited


Envelope Protein Viral Envelope Protein Glycan Processing Cell BioI Alternate Translation Initiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Timothy M. Block
    • 1
  • Xuanyong Lu
    • 1
  • Anand Mehta
    • 1
    • 2
  • Jason Park
    • 1
  • Baruch S. Blumberg
    • 2
    • 3
  • Raymond Dwek
    • 3
  1. 1.Viral Hepatitis GroupKimel Cancer Center of Jefferson Medical CollegePhiladelphiaUSA
  2. 2.Glycobiology IntsituteOxford UniversityOxfordUK
  3. 3.Fox Chase Cancer CenterPhiladelphiaUSA

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