Abstract
The complex-type glycan structures of acute-phase glycoproteins (APPs) are subject to marked changes during acute and chronic inflammation (see for review Van Dijk et al., 1994). In vivo studies with mice transgenic for human α1,-acid glycoprotein (AGP) and in vitro studies with human hepatoma cell lines (Mackiewicz et al., 1991) and isolated human and rat hepatocytes (Pos et al., 1988; Pos et al. 1989; Van Dijk et al., 1991a; Van Dijk et al. 1991b) have indicated that these changes are not simply determined by changes in serum concentration or in secretion rates of acute-phase glycoproteins. The biosynthesis of the glycans in the hepatocytes of the liver appeared to be affected as part of the hepatic acute-phase reaction. Inflammatory cytokines, like IL-6 and IL-lα, and glucocorticoids are involved in the regulation of these processes.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bierhuizen, M.F.A., De Wit, M., Govers, C.A.R.L., Ferwerda, W., Koeleman, C., Pos, O., and Van Dijk, W., 1988, Glycosylation of three molecular forms of human α1,-acid glycoprotein having different interactions with Concanavalin A: Variations in the occurrence of bi-, tri-, and tetraan-tennary glycans and the degree of sialylation, Eur. J. Biochem. 175:387.
Brinkman-Van der Linden, E.C.M., Van Ommen, E.C.R., and Van Dijk, W., 1996a, Glycosylation of α1-acid glycoprotein in septic shock: changes in degree of branching and in expression of sialyl Lewisx groups, Glycoconj. J. 13:1.
Brinkman-Van der Linden, E.C.M., Mollicone, R., Oriol, R., Larson, G., Van den Eijnden, D.H., and Van Dijk, W., 1996b, A missense mutation in the FUT6 gene results in the total absence of α3-fucosylation of human α1-acid glycoprotein, J. Biol. Chem. 271:14492.
Brinkman-Van der Linden, E.C.M., Havenaar, E.G., Van Ommen, E.C.R., Van Kamp, G.J., Gooren, L.J.G., and Van Dijk W, 1996c, Oral estrogen treatment induces a decrease in expression of SLeX on AGP in females and male-to-female transsexuals, Glycobiology 6:407.
Brinkman-Van der Linden, E.C.M., 1997a, Inflammation-induced expression of sialyl Lewisx on α1,-acid glycoprotein: Occurrence, regulation and function, Chapter 5 in Ph.D. Thesis, Ponsen $ Looijen, Wageningen.
Brinkman-Van der Linden, E.C.M., 1997b, Inflammation-induced expression of sialyl Lewisx on α1,-acid glycoprotein: Occurrence, regulation and function, Chapter 7 in Ph.D. Thesis, Ponsen $ Looijen, Wageningen.
Dobryszycka, W., 1993, Haptoglobin: Retrospectives and perspectives, in: “Acute phase proteins: Molecular biology, biochemistry and clinical applications”, A. Mackiewicz, I. Kushner, and H. Baumann, eds. Boca Raton, CRC press, 185.
De Graaf, T.W., Van der Stelt, M.E., Anbergen, M.G., and Van Dijk, W., 1993, Inflammation-induced expression of sialyl Lewis X-containing glycan structures on α1,-acid glycoprotein (orosomucoid) in human sera, J. Exp. Med. 177:657.
De Graaf, T.W., Van Ommen, E.C.R., Van der Stelt, M.E., Kerstens, P.J.S.M., Boerbooms, A.M.Th., and Van Dijk W., 1994, Effects of low-dose methotrexate therapy on the concentration and the glycosylation of α1,-acid glycoprotein in the serum of rheumatoid arthritis patients: A longitudinal study, J. Rheumatol. 21:2209.
Fournet, B., Montreuil, J., Strecker, G., Dorland, L., Haverkamp, J., Vliegenthart, J.F.G., Binette, J.P., and Schmid, K., 1978, Determination of the primary structures of 16 asialo-carbohydrate units derived from human plasma α1,-acid glycoprotein by 360-MHz 1H NMR spectroscopy and permethylation analysis Biochemistry 17:5206.
Havenaar, E.G., Drenth, J.P.H., Van Ommen, E.C.R., Van der Meer, J.W.M., and Van Dijk, W., 1995, Elevated serum level and altered glycosylation of α1,-acid glycoprotein in hyperimmunoglobulin-emia D and periodic fever syndrome: Evidence for persistent inflammation, Clin. Immunol. Immunopathol. 76:279.
Havenaar, E.C., Axford, J.F., Brinkman-Van der Linden, E.C.M., Alavi, A., Spector, T., and Van Dijk W., 1996, Effect of pregnancy on glycosylation of α1,-acid glycoprotein in rheumatoid arthritis, Glycoconj. J. 13:899.
Havenaar, E.C., Dolhain, R.J.E.M., Turner, G.A., Goodarzi, M.T., Van Ommen, E.C.R., Breedveld, F.C., and Van Dijk, W., 1997, Do synovial fluid acute-phase proteins from patients with rheumatoid arthritis originate from serum Glycoconj. J. 14:in press.
Hodges, L.C., Laine, R., and Kai Chan, S., 1979, Structure of the oligosaccharide chains in human α1,-protease inhibitor J. Biol. Chem. 254:8208.
Joziasse, D.H., Schiphorst, W.E.C.M., Van den Eijnden, D.H., Van Kuik, J.A., Van Halbeek, H., and Vliegenthart, J.F.G., 1987, Branch specificity of bovine colostrum CMP-sialic acid: Galβl→4-GlcNAc-R α2→6-sialyltransferase. Sialylation of bi-, tri-and tetraantennary oligosaccharides and glycopeptides of the N-acetyllactosamine type J. Biol. Chem. 262:2025.
Laine, A., Hachulla, E., Strecker, G., Michalski, J.-C., and Wieruszeski, J.-M., 1991, Structure determination of the glycans of human-serum α1,-antichymotrypsin using 1H-NMR spectroscopy and deglycosylation by N-glycanase Eur. J. Biochem. 197:209.
Mackiewicz, A., Pos, O., Van der Stelt, M.E., Yap, S.H., Kapcinska, M., Laciak, M., Dewey, M.J., Berger, F.G., Baumann, H., Kushner, I., and Van Dijk, W., 1991, Regulation of glycosylation of acute-phase proteins by cytokines in vitro, Chapter 9, in: “Affinity Electrophoresis: Principles and Application,” J. Breborowicz, and A. Mackiewicz, A., eds., CRC Press, Boca Raton.
Mega, T., Lujan, E., and Yoshida, A., 1980, Studies on the oligosaccharide chains of human α1,-protease inhibitor. II Structure of oligosaccharides J. Biol. Chem. 255:4057.
Paulson, J.C., Prieels, J.P., Glasgow, L.R., and Hill, R.L., 1978, Sialyl-and fucosyltransferases in the biosynthesis of asparaginyl-linked oligosaccharides in glycoproteins. Mutual exclusive glycosylation by β-galactoside α2→6sialyltransferase and N-acetylglucosaminide αl→3-fucosyl-transferase J. Biol. Chem. 253:5617.
Pos, O., Van Dijk, W., Ladiges, N., Linthorst, C., Sala, M., Van Tiel, D., and Boers, W., 1988, Glycosylation of four acute-phase glycoproteins secreted by rat liver cells in vivo and in vitro: Effects of inflammation and dexamethasone, Eur. J. Cell Biol. 46:121.
Pos, O., Boers, W., Moshage, H.J., Yap, S.H., Aarden, L.A., Van Gool, J., Brugman, A.M., and Van Dijk W., 1989, Effects of monocytic products, recombinant interleukin-1 and interleukin-6 on the glycosylate of α1,-acid glycoprotein: Studies with primary human hepatocyte and rats, Inflammation 13:415.
Pos, O., Van der Stelt, M.E., Wolbink, G.J., Nijsten, M.W.N., Van der Tempel, G.L., and Van Dijk, W., 1990, Changes in the serum concentration and the glycosylate of human α1,-acid glycoprotein and α1,-protease inhibitor in severely burned patients: relation to interleukin-6 levels, Clin. Exp. Immunol. 82:579.
Raynes, J., 1982, Variations in the relative proportions of microheterogeneous forms of plasma glycoproteins in pregnancy and disease, Biomedicine 36:77.
Schmid, K., Nimberg, R.B., Kimura, A., Yamaguchi, H., and Binette, J.P., 1977, The carbohydrate units of human plasma α1,-acid glycoprotein, Biochim. Biophys. Acta 492:291.
Steegmaler, M., Levinovitz, A. Isenmann, S., Borges, E., Lenter, M., Kocher, H.P., Kleuser, B., and Vestweber, D., 1995, The E-selectin ligand ESL-1 is a variant of the fibroblast growth receptor Nature 373:615.
Van Dijk, W., Van der Stelt, M.E., Salera, A., and Dente, L., 1991a, Effect of transgenic expression of human alpha 1-acid glycoprotein (AGP) on the glycosylate of human and mouse AGP in various transgenic mouse sera, Eur. J. Cell Biol. 55:143.
Van Dijk, W., Pos, O., Van der Stelt, M.E., Moshage, H.J., Yap, S.H., Dente, L., Baumann, P., and Eap C.B., 1991b, Inflammation-induced changes in expression and glycosylate of genetic variants of α1-acid glycoprotein (AGP); Studies with human sera, primary cultures of human hepatocytes and transgenic mice, Biochem. J. 276:343.
Van Dijk, W., Turner, G.A., and Mackiewicz, A., 1994, Changes in glycosylate of acute-phase proteins in health and disease: Occurrence, regulation and function, Glycosyl. Disease 1:5.
Van Dijk, W., Havenaar, E.C., and Brinkman-Van der Linden, E.C.M., 1995, α1,-Acid glycoprotein (orosomucoid): Pathophysiological changes in glycosylate in relation to its function, Glycoconj. J. 12:227.
Van der Linden, E.C.M., De Graaf, T.W., Anbergen, M.G., Dekker, R.M., Van Ommen, E.C.R., Van den Eijnden, D.H., and Van Dijk, W., 1994, Preparative affinity electrophoresis of different glycoforms of serum glycoproteins: Application for the study of inflammation induced expression of sialyl-Lewisx groups on alpha 1-acid glycoprotein (orosomucoid), Glycosyl. Disease 1:45.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Van Dijk, W., Brinkman-Van der Linden, E.C.M., Havenaar, E.C. (1998). Occurrence and Possible Function of Inflammation-Induced Expression of Sialyl Lewis-X on Acute-Phase Proteins. In: Axford, J.S. (eds) Glycoimmunology 2. Advances in Experimental Medicine and Biology, vol 435. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5383-0_14
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5383-0_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7457-2
Online ISBN: 978-1-4615-5383-0
eBook Packages: Springer Book Archive