Abstract
Our laboratory has had a sustained interest in development and use of animal models of epilepsy, and some of our previous studies were included in the proceedings of the Kindling 4 conference17. One of the reasons the kindling model has been of special interest is because the slow development of the electroencephalographic and behavioral events associated with it provide us with the opportunity to study the transitional events leading to the final kindled state. We have exploited the model from both the pharmacological and the toxicological point of view. On the pharmacological side, we have studied many conventional and novel compounds for their effects on retardation of kindling development, or on fully kindled seizures1,2,11,13 On the toxicological side, we have reported the proconvulsant effects of a number of compounds, including lindane12–14, a chlorinated hydrocarbon insecticide which was previously broadly used throughout the world and is still the principal ingredient in a medicated shampoo. The work to be described is a direct outgrowth and extension of studies previously reported on lindane, and we have sought to compare it with several other convulsants known to interact with the GABA-A receptor-chloride ionophore complex by examining the electrophyiological consequences of exposing hippocampal slices to each of them.
Deceased, November 1995.
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References
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Stark, L.G., Joy, R.M., Walby, W.F., Albertson, T.E. (1998). Interactions Between Convulsants at Low-Dose and Phenobarbital in the Hippocampal Slice Preparation. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_32
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