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Perforant Path Kindling, NMDA Antagonism, and Late Paired Pulse Depression

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Kindling 5

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 48))

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Abstract

The N-methyl-d-aspartate (NMDA) subtype of the glutamate receptor has been strongly implicated in the development of limbic kindling9,4,18.20,25,27,33 Antagonists of NMDA have been reported to increase afterdischarge (AD) thresholds and retard the development of motor seizures. In the amygdala, the development of electrographic as well as behavioral seizures is profoundly reduced by the noncompetitive NMDA antagonist, MK-801. Paradoxically, an augmentation rather than a retardation in AD duration is evident in animals kindled in the perforant path following treatment with MK-80115,16,18

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Authors and Affiliations

  1. Neurotoxicology Division, US Environmental Protection Agency, National Research Council, Research Triangle Park, North Carolina, USA

    Mary E. Gilbert PhD

  2. Department of Psychology, University of North Carolina, Chapel Hill, North Carolina, USA

    Mary E. Gilbert PhD

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  1. Mary E. Gilbert PhD
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Correspondence to Mary E. Gilbert PhD .

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Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Michael E. Corcoran

  2. Albert Einstein College of Medicine, Bronx, New York, USA

    Solomon L. Moshé

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Gilbert, M.E. (1998). Perforant Path Kindling, NMDA Antagonism, and Late Paired Pulse Depression. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_30

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  • DOI: https://doi.org/10.1007/978-1-4615-5375-5_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7453-4

  • Online ISBN: 978-1-4615-5375-5

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