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Mitosis and checkpoints that control progression through mitosis in vertebrate somatic cells

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

During mitosis in vertebrates the sister kinetochores on each replicated chromosome interact with two separating arrays of astral microtubules to form a bipolar spindle that produces and/or directs the forces for chromosome motion. In order to ensure faithful chromosome segregation cells have evolved mechanisms that delay progress into and out of mitosis until certain events are completed. At least two of these mitotic ‘checkpoint controls’ can be identified in vertebrates. The first prevents nuclear envelope breakdown, and thus spindle formation, when the integrity of some nuclear component(s) is compromised. The second prevents chromosome disjunction and exit from mitosis until all of the kinetochores are attached to the spindle.

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Abbreviations

Mt:

microtubule

K-fiber:

kinetochore fiber

P:

poleward

AP:

away-from-the-pole

NEB:

nuclear envelope breakdown

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Authors and Affiliations

  1. Laboratory of Cell Regulation, Division of Molecular Medicine, Wadsworth Center, P. O. Box 509, Albany, New York, 12201-0509, USA

    Conly L. Rieder & Alexey Khodjakov

  2. Department of Biomedical Science, State University of New York, Albany, New York, 12222, USA

    Conly L. Rieder

  3. Marine Biology Laboratory, Woods Hole, MA, 02543, USA

    Conly L. Rieder

Authors
  1. Conly L. Rieder
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  2. Alexey Khodjakov
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. Centre National de la Recherche Scientifique, Université de Rennes I, Rennes, France

    Michel Philippe

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Rieder, C.L., Khodjakov, A. (1997). Mitosis and checkpoints that control progression through mitosis in vertebrate somatic cells. In: Meijer, L., Guidet, S., Philippe, M. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5371-7_24

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