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In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The cyclin B/Cdc2 complex, Cdc2 kinase governs M-phase. Although the intracomplex modification for its activation in vitro has been described extensively, its regulation in vivo is not so well explained so far. In this article, we will focus on the intracellular regulation of the cyclin B/Cdc2 activity, in particular, how it is initially activated in vivo, how its nuclear translocation is executed specifically at the onset of M-phase, and how the activation and the nuclear translocation are coordinated in the cell. These concerted regulations may determine the appropriate timing for the initiation of M-phase.

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Author information

Authors and Affiliations

  1. Laboratory of Cell and Developmental Biology, Faculty of Biosciences and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 226, Japan

    Takeo Kishimoto & Eiichi Okumura

Authors
  1. Takeo Kishimoto
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  2. Eiichi Okumura
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. Centre National de la Recherche Scientifique, Université de Rennes I, Rennes, France

    Michel Philippe

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Kishimoto, T., Okumura, E. (1997). In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2. In: Meijer, L., Guidet, S., Philippe, M. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5371-7_19

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  • DOI: https://doi.org/10.1007/978-1-4615-5371-7_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7451-0

  • Online ISBN: 978-1-4615-5371-7

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