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Neoplastic Progression in Barrett’s Esophagus

  • Chapter
Genomic Instability and Immortality in Cancer

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 8))

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Abstract

In 1976, Nowell hypothesized that cancer develops as a consequence of an acquired genomic instability that predisposes to the development of abnormal clones of cells with accumulated genetic errors (Nowell, 1976). Some clones gain selective proliferative advantages, and eventually a subclone evolves that has acquired the capacity for invasion, becoming an early carcinoma. There is now substantial evidence that human cancers develop in association with a process of genetic instability and clonal evolution that leads to the accumulation of genetic errors (Vogelstein, et al., 1988; Sidransky, et al., 1992; Raskind, et al., 1992; Huang, et al., 1992). However, few human model systems have been developed in which it is possible to investigate the sequence of events that leads to the development of a carcinoma in vivo. Many studies have focused on the genetic abnormalities that are present in advanced carcinomas in surgical specimens. Although the study of advanced cancers is useful for identifying genetic abnormalities that have accumulated in the cancer, the ability of this approach to determine the order in which genetic and other abnormalities develop during earlier stages of neoplastic progression is limited.

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Authors and Affiliations

  1. Program in Cancer Biology, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98104, USA

    Michael T. Barrett, Carissa A. Sanchez, Patricia C. Galipeau, David S. Cowan & Brian J. Reid MD, PhD

  2. Division of Gastroenterology 356424 Department of Medicine, University of Washington Medical Center, Seattle, Washington, 98195, USA

    Katayoun Neshat, Douglas S. Levine & Brian J. Reid MD, PhD

  3. Program in Cancer Biology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98104, USA

    Brian J. Reid MD, PhD

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  1. Michael T. Barrett
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  2. Carissa A. Sanchez
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  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. University of Washington, Seattle, Washington, USA

    Leland Hartwell

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Barrett, M.T. et al. (1997). Neoplastic Progression in Barrett’s Esophagus. In: Mihich, E., Hartwell, L. (eds) Genomic Instability and Immortality in Cancer. Pezcoller Foundation Symposia, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5365-6_14

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  • DOI: https://doi.org/10.1007/978-1-4615-5365-6_14

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