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Breakup and Dewetting of the Corneal Mucus Layer

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

Abstract

The normal precorneal tear film usually remains intact between consecutive blinks, but holes begin to appear and grow at random spots in about 10–60 sec when blinking is prevented. Although the exact mechanism of the tear film breakup has eluded our understanding, it is certain that the breakup is secondary to the nonwettability of the corneal surface. We had earlier proposed a mechanism based on the possibility of the rupture and dewetting of the precorneal mucus layer due to the long-range van der Waals forces.1–4 The tear breakup was thought to be triggered by the “hydrophobicity,” or nonwettability, of the underlying corneal epithelial surface devoid of its mucus covering.

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References

  1. Sharma A, Ruckenstein E. Mechanism of tear film breakup and formation of dry spots on cornea. J Colloid Interface Sci. 1985; 106: 12–27.

    Article  Google Scholar 

  2. Sharma A, Ruckenstein E. Mechanism of tear film breakup and its implications for contact lens tolerance. Am J Optom Physiol Opt. 1985; 62: 246–253.

    Article  PubMed  CAS  Google Scholar 

  3. Sharma A, Ruckenstein E. The role of lipid abnormalities, aqueous and mucus deficiencies in the tear film breakup and implications for tear substitutes and contact lens tolerance. J Colloid Interface Sci. 1986; 111: 8–21.

    Article  CAS  Google Scholar 

  4. Ruckenstein E, Sharma A. A surface chemical explanation of tear film breakup and its implications. In: Holly FJ, Lamberts DW, MacKeen DL, eds. The Preocular Tear Film in Health, Disease, and Contact Lens Wear. Lubbock, TX: Dry Eye Institute; 1986: 697–727.

    Google Scholar 

  5. Reiter G. Dewetting of thin polymer films. Phys Rev Lett. 1992;68:75–78.

    Article  PubMed  CAS  Google Scholar 

  6. Reiter G. Unstable thin polymer films. Langmuir. 1993; 9: 1344–1351.

    Article  CAS  Google Scholar 

  7. Redon C, Brzoska JB, Brochard-Wyart F. Dewetting and slippage of microscopic polymer films. Macromolecules. 1994; 27: 468–471.

    Article  CAS  Google Scholar 

  8. Yerushalmi-Rozen R, Klein J, Fetters LJ. Supression of rupture in thin nonwetting liquid films. Science. 1994; 263: 793–795.

    Article  PubMed  CAS  Google Scholar 

  9. Yerushalmi-Rozen R, Klein J. Stabilization of nonwetting thin liquid films on a solid substrate by polymeric additives. Langmuir. 1995; 11: 2806–2814.

    Article  CAS  Google Scholar 

  10. Faldi A, Composto R.1, Winey Kl. Unstable polymer layers. Langmuir. 1995; 11: 4855–4861.

    Article  CAS  Google Scholar 

  11. Guerra JM, Srinivasarao M, Stein RS. Photon tunneling microscopy of polymeric surfaces. Science. 1993; 262: 1395–1400.

    Article  PubMed  CAS  Google Scholar 

  12. Sharma A, Reiter G. Instability of thin polymer films on coated substrates. J Colloid Interface Sei. 1996; 178: 383–399.

    Article  CAS  Google Scholar 

  13. de Gennes PG. OR Acad Sci. 1979; 228B: 219–224.

    Google Scholar 

  14. Brochard-Wyart F; de Gennes PG, Hervert H, Redon C. Wetting and slippage of polymer melts on semi-ideal surfaces. Langmuir. 1994;10:1566–1572.

    Article  CAS  Google Scholar 

  15. Sharma A, Khanna R Macromolecules. Nonlinear stability of microscopic polymer films with slippage. 1996; 29: 6959–6961.

    CAS  Google Scholar 

  16. Tiffany JM. Measurements of wettability of the corneal epithelium. I particle attachment method. Acta Ophthalmol. 1990;68:175–181.

    CAS  Google Scholar 

  17. Tiffany JM. Measurements of wettability of the corneal epithelium. II contact angle method. Acta Ophthalmol. 1990; 68: 182–187.

    CAS  Google Scholar 

  18. Sharma A. Surface properties of damaged and normal corneal epithelia. J Dispersion Sci Tech, 1992; 13: 459 - 478.

    Article  CAS  Google Scholar 

  19. Sharma A. Energetics of corneal epithelial cell-ocular mucus-tear film interactions. Biophys Chem. 1993; 47: 87–99.

    Article  PubMed  CAS  Google Scholar 

  20. Sharma A. This volume.

    Google Scholar 

  21. Nichols BA, Chiappino ML, Dawson. Demonstration of the mucous layer of the tear film by electron microscopy. Invest Ophthalmol Vis Sci. 1985; 26: 464–473.

    PubMed  CAS  Google Scholar 

  22. Prydal JI, Artal P, Woon H, Campbell FW. Study of human precorneal tear film thickness and structure by interferometry. Invest Ophthalmol Vis Sci. 1992; 33: 2006–2011.

    PubMed  CAS  Google Scholar 

  23. Adams AD. In: Holly FJ, Lamberts DW, MacKeen DL, eds. The Preocular Tear Film in Health, Disease, and Contact Lens Wear. Lubbock, TX: Dry Eye Institute: 1986: 304–311.

    Google Scholar 

  24. Khesgi HS, Scriven LE. Dewetting: nucleation and growth of dry regions. Chem Eng Sci. 1991; 46: 519–525.

    Article  Google Scholar 

  25. Sharma A. Relationship of thin film stability and morphology to macroscopic parameters of wetting in the apolar and polar systems. Langmuir. 1993; 9: 861–869.

    Article  CAS  Google Scholar 

  26. Sharma A, Jameel AT. Nonlinear stability, rupture and morphological phase separation of thin fluid films. J Colloid Interface Sci. 1993;161:190–208

    Article  CAS  Google Scholar 

  27. Sharma A, Jameel AT. Stability of thin polar films on nonwettable substrates. J Chem Soc Faraday Trans. 1994; 90: 625–628.

    Article  CAS  Google Scholar 

  28. Khanna R, Jameel AT, Sharma A. Stability and breakup of thin polar films on coated substrates. Ind Eng Chem Res. 1996; 35: 3081–3092.

    Article  CAS  Google Scholar 

  29. van Oss CJ, Chaudhury MK, Good RJ. Interfacial Lifshitz-van der Waals and polar interactions in macroscopic systems. Chem Rev. 1988; 88: 927–941.

    Article  Google Scholar 

  30. van Oss CJ. Acid-base interfacial interactions in aqueous media. Colloids Surf A. 1993; 78: 1–49.

    Article  Google Scholar 

  31. Ruckenstein E, Jain RK. Spontaneous rupture of thin liquid films. J Chem Soc Faraday Trans II. 1974; 70: 132–141.

    Article  CAS  Google Scholar 

  32. Sharma A, Kishore CS, Salaniwal S, Ruckenstein E. Nonlinear stability and rupture of ultrathin free films. Phys Fluids A. 1995; 9: 1832–1840.

    Google Scholar 

  33. Holly FJ, Lemp MA. Wettability and wetting of corneal epithelium. Exp Eye Res. 1971; 11: 239–250

    Article  PubMed  CAS  Google Scholar 

  34. Holly FJ, Lemp MA. Formation and rupture of the tear film. Exp Eye Res. 1973; 15: 515–525.

    Article  PubMed  CAS  Google Scholar 

  35. Sharma A, Coles WH. Physico-chemical factors in tear film breakup. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1990; 31: S552.

    Google Scholar 

  36. Sharma A. Perturbation analysis of surface dewetting by formation of holes. J Colloid Interface Sci. 1993; 156: 96–103.

    Article  CAS  Google Scholar 

  37. Klatz SA, Au YK, Misra RP. A partial thickness epithelial defect increases the adherence of Pseudomonas aeruginosato the cornea. Invest Ophthalmol Vis Sci. 1989; 30: 1069–1074.

    Google Scholar 

  38. Sokol JL, Masur SK, Asbell PA, Wolosin JM. Layer-by-layer desquamation of corneal epithelium and maturation of tear-facing membranes. Invest Ophthalmol Vis Sci. 1990; 31: 294–304.

    PubMed  CAS  Google Scholar 

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Sharma, A. (1998). Breakup and Dewetting of the Corneal Mucus Layer. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_39

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

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