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Structural Analysis of Secreted Ocular Mucins in Canine Dry Eye

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

Abstract

The tear film is vital for the normal function of the ocular surface, influencing transparency, optical quality, and defense against the external environment. A functional understanding of the tear film depends on a knowledge of its components and their interactions. Recent data indicate the thickness of the trilaminar tear film to be 35–40 μm, the majority (~30 μm) contributed by a mucous gel situated adjacent to the epithelial surface.1–3 This gel contains mainly secreted mucins, which interact with a variety of other components, including a number of highly glycosylated components of the ocular surface glycocalyx.4–7

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Author information

Authors and Affiliations

  1. Department of Anatomy, School of Veterinary Science, University of Bristol, England, UK

    Stephen D. Carrington & Sally J. Hicks

  2. Department of Medicine Laboratories, Bristol Royal Infirmary, Bristol, England, UK

    Anthony P. Corfield

  3. College of Veterinary Medicine, University of Georgia, Athens, Georgia

    Renee L. Kaswan

  4. Macquarie University Centre for Analytical Biochemistry, Macquarie University, Sydney, Australia

    Nicki Packer

  5. Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia

    Shirley Bolis & Carol A. Morris

Authors
  1. Stephen D. Carrington
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  2. Sally J. Hicks
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  3. Anthony P. Corfield
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  4. Renee L. Kaswan
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  5. Nicki Packer
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  6. Shirley Bolis
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Editor information

Editors and Affiliations

  1. The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  2. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Michele A. Meneray

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© 1998 Springer Science+Business Media New York

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Carrington, S.D. et al. (1998). Structural Analysis of Secreted Ocular Mucins in Canine Dry Eye. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_37

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

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