Abstract
There are two general requirements to be met by a viral vector. One is the ability to carry and deliver a stretch of heterologous DNA and a second is a distinct host cell tropism, providing that only a desired population of target cells is infected. The B-lymphot-ropic papovavirus (LPV), with its extremely narrow, receptor-mediated host range, may be the basis for a tissue specific viral vector.
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Abbreviations
- DNA:
-
Desoxyribonucleic acid
- LPV:
-
B-lymphotropic papovavirus
- SV40:
-
Simian virus 40
- Py:
-
Murine Polyomavirus
- VP1/2/3:
-
Viral protein 1/2/3
- VLP:
-
Viruslike particles
- RGD:
-
Arginine glycine aspartic acid
- ORF:
-
Open reading frame
- AcNPV:
-
Autographa californica nuclear polyhedrosis virus
- Sf 9:
-
Cell line established from the insect Spodoptera frugiperda
- IgG:
-
Immunoglobulin G; FITC: Fluoresceinisothiocyanate
- TRITC:
-
Tertamethyl-rhodamin-isothiocyanat
- PBS:
-
Phosphate buffered saline
- 3-D:
-
Three-dimensional
- T:
-
Threonine
- D:
-
Aspartic acid
- K:
-
Lysine
- G:
-
Glycine
- FMDV:
-
Foot and mouth disease virus
- CAV-9:
-
Coxsackie virus serotype A9
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Langner, J., Zentgraf, H., Pawlita, M. (1998). Viral Particles with Heterologous Binding Motifs. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_64
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DOI: https://doi.org/10.1007/978-1-4615-5357-1_64
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