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Heat Shock Protein (HSP72) Surface Expression Enhances the Lysis of a Human Renal Cell Carcinoma by IL-2 Stimulated NK Cells

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Gene Therapy of Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 451))

Abstract

Patients with advanced renal cell carcinoma (RCC) have a poor prognosis due to the failure of this tumor entity to respond to conventional therapeutic approaches such as irradiation or chemotherapy. Since the introduction of interleukin-2 based immunotherapy by Rosenberg et al. there has been some clinical progress in the treatment of metastatic RCC [1].

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Abbreviations

RCC:

Renal Cell Carcinoma

IL-2:

Interleukin-2

HSP:

Heat Shock Proteins

NK cells:

Natural Killer Cells

MHC:

Major Histocompatibility Complex

MoAb:

monoclonal antibody

References

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Author information

Authors and Affiliations

  1. Dept. of Urology, Charité Medical School, Humboldt Univ. of Berlin, Schumannstr. 20/21, 10098, Berlin, Germany

    Jan Roigas M.D. & S. A. Loening

  2. Department of Internal Medicine Health Sciences Center, University of New Mexico, 87131-5271, Albuquerque, New Mexico, USA

    E. S. Wallen & P. L. Moseley

Authors
  1. Jan Roigas M.D.
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  2. E. S. Wallen
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  3. S. A. Loening
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  4. P. L. Moseley
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Corresponding author

Correspondence to Jan Roigas M.D. .

Editor information

Editors and Affiliations

  1. Humboldt University, Berlin, Germany

    Peter Walden , Uwe Trefzer , Wolfram Sterry  & Patricia Zambon , ,  & 

  2. King’s College School of Medicine and Dentistry, London, UK

    Farzin Farzaneh

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© 1998 Springer Science+Business Media New York

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Roigas, J., Wallen, E.S., Loening, S.A., Moseley, P.L. (1998). Heat Shock Protein (HSP72) Surface Expression Enhances the Lysis of a Human Renal Cell Carcinoma by IL-2 Stimulated NK Cells. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_35

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  • DOI: https://doi.org/10.1007/978-1-4615-5357-1_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7444-2

  • Online ISBN: 978-1-4615-5357-1

  • eBook Packages: Springer Book Archive

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