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Innate Functions of Epithelial γδ T Cells

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Mechanisms of Lymphocyte Activation and Immune Regulation VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 452))

Abstract

γδ T cells are present in every epithelial tissue tested. Several features of the ontogeny, tissue tropism, and antigen receptor diversity of the epithelial γδ T cells are distinct from lymphoid γδ and αβ T cells(1), γδ T cells are the first T cells which appear during ontogeny in the thymus. Vγ and Vδ gene segments of the T cell antigen receptor (TCR) are rearranged and expressed sequentially according to location on the chromosome. In the adult mouse, there is localization of specific V region expressing subsets of γδ T cells to distinct tissue sites. This V region tissue tropism is conserved in all mouse strains tested. In humans, there is also preferential expression of specific Vγ and Vδ regions in tissue and lymphoid locations. αβ TCR are quite diverse with random pairing of V gene segments and extensive addition of non-germline encoded nucleotides at recombination junctions. In contrast, there is biased pairing of Vγ and Vγ segments with decreased or absent junctional diversity. Indeed the populations of γδ T cells present in murine skin and vaginal epithelium express monoclonal TCR only found in those tissues. These results suggest that γδ T cells may be capable of recognizing a much more limited repertoire of antigens than the αβ T cells.

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Author information

Authors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, La Jolla, California, 92037, USA

    Wendy L. Havran, Yaping Chen & Richard Boismenu

Authors
  1. Wendy L. Havran
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  2. Yaping Chen
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  3. Richard Boismenu
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Editor information

Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. National Institutes of Health, Bethesda, Maryland, USA

    Alan Sher

  3. Emory University, Atlanta, Georgia, USA

    Rafi Ahmed

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© 1998 Springer Science+Business Media New York

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Havran, W.L., Chen, Y., Boismenu, R. (1998). Innate Functions of Epithelial γδ T Cells. In: Gupta, S., Sher, A., Ahmed, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VII. Advances in Experimental Medicine and Biology, vol 452. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5355-7_4

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  • DOI: https://doi.org/10.1007/978-1-4615-5355-7_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7443-5

  • Online ISBN: 978-1-4615-5355-7

  • eBook Packages: Springer Book Archive

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