Abstract
The main neurochemial characteristic of the Parkinson’s disease is a marked degeneration of the nigrostriatal dopaminergic neurons which provide the dopaminergic striatal innervation. Due to the complex chemoarchitectiture of the Central Nervous System (CNS), drug delivery to a very restricted region of the brain is always required. The treatment of Parkinson’s disease patients with the dopamine biosynthetic precursor, levodopa in conjunction with a decarboxylase inhibitor 1 has received wide acceptance as an effective approach for the reduction of extrapyramidal symptoms in Parkinson’s disease. With the current convential medication levodopa can cause serious adverse effect reactions and its effectiveness decreases with time. However, implanted polymeric devices releasing the appropriate pharmacological agent could restore neurotransmission and lead to functional improvement.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A. Barbeau, 1974, The clinical physiology of side effects in long-term 1-dopa therapy, Adv. Neurol 5:347–356
WM. Pardridge, 1996 Brain drug delivery and blood-brain barrier transport. Drug Delivery 3: 99–115.
M. Iwata and J.W. McGinity, 1992, Preparation of multiphase microspheres of poly(d,l-lactic-co-glycolic acid) containing a w/o emulsion by a multiple emulsion solvent evaporeation technique, J. Microencap 9:201–214
R. Alex and R. Bodmeier, 1990, Encapsulation of water-soluble drugs by a modinea solvent evaporation method. I. Effect of process and formation variables on drug entrapment, J. Microencap 7:341–355
B. Arıca, H.S. Kaş, M. Orman, H.H. Çelik and A.A. Hıncal, 1996, Proceed. 8th Inter. Pharm. Technol. Symp. (IPTS-96), Sept. 9–11, pp.167
P.K. Gupta, C.T. Hung and D.G. Perrier, 1986a, Albumin microspheres I: release characteristics of adriamycin. Int. J. Pharm 33:137–146
P.K. Gupta, C.T. Hung and D.G. Perrier, 1986a, Albumin microspheres II: Effect of stabilization temperature on the release of adriamycin. Int. J. Pharm 33:147–153
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Arıca, B., Kaş, H.S., Hıncal, A.A. (1998). Evaluation and Formulation of Biodegradable Levodopa Microspheres Using 32 Factorial Design. In: Hıncal, A.A., Kaş, H.S. (eds) Biomedical Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5349-6_4
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5349-6_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7440-4
Online ISBN: 978-1-4615-5349-6
eBook Packages: Springer Book Archive