Morphine Alters the Immune Response to Influenza Virus Infection in Lewis Rats
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Abstract
It has been well-documented that administration of opioids can alter immune function in vitro. Initial studies of chronic heroin users demonstrated that this population has decreased mitogenic responsiveness of blood lymphocytes to lipopolysaccharide, poke- weed mitogen, and concanavalin-A, suggesting an impairment of cellular immunity (1). Subsequent studies have shown that chronic heroin users also exhibit diminished T-cell E-rosetting (2), reductions in the total number of T-cells present in the peripheral blood (3), and decreases in the number of T-helper cells in the blood (4). Taken together, these studies demonstrate that chronic heroin use can alter immune function, and may thereby affect disease susceptibility and pathogenesis.
Keywords
Natural Killer Cell Activity Madin Darby Canine Kidney Influenza Virus Infection Morphine Treatment Chronic Morphine Treatment
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References
- 1.Brown, B. Stimmell, R.N. Taub, S. Kochwa, and R.E. Rosenfield, R.E., Immunologic dysfunction in heroin addicts, Arch. Int. Med, 134: 1001 (1974).CrossRefGoogle Scholar
- 2.R.M. Donahoe, J.J. Madden, F. Hollingworth, D. Shafer, and A. Falek, Morphine depression of T-cell E-rossetting: Definition of the process, Proc. Am. Soc. Exp. Biol., 44: 95 (1985).Google Scholar
- 3.R.J. McDonough, J.J. Madden, A. Falek, D.A. Shafer, M. Pline, D. Gordon., P. Bokos, J.C. Kuehnie, and J. Mendelson, Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: In vivo evidence for opiate receptor sites on T lymphocytes, J. Immunol., 125: 2539 (1980).PubMedGoogle Scholar
- 4.R.M. Donahoe, C. Buesos-Ramos, F. Donahoe, J.J. Madden, and A. Falek, Mechanistic implications of the finding that opiates and other drugs of abuse moderate T-cell surface receptors and antigenic markers, Ann. New York Acad. Sci., 496: 711 (1987).CrossRefGoogle Scholar
- 5.H.U. Bryant, E.W. Bernton, and J.W. Holaday, Immunosuppressive effects of chronic morphine treatment in mice, Life Sci., 41: 1731 (1987).PubMedCrossRefGoogle Scholar
- 6.H.U. Bryant, E.W. Berton, E.W., and J.W. Holaday, Morphine pellet-induced immunomodulation in mice: Temporal relationships, J. Pharm. Exp. Ther., 245: 913 (1988).Google Scholar
- 7.R.J. Weber, B. Ikejiri, K.C. Rice, A. Pert, and A.A. Hagan, Opiate receptor mediated regulation of the immune response in vivo, in Problems of Drug Dependence, L.S. Harris. Ed., NIDA Res. Monogr., 76: 341 (1987).Google Scholar
- 8.Y. Shavit, J.W. Lewis, G.W. Terman, R.P. Gale, and J.C. Liebeskind, Opioid peptides mediate the suppres-sive effect of stress on natural-killer cell cytotoxicity, Science, 223: 188 (1984).PubMedCrossRefGoogle Scholar
- 9.S.S. Lefkowitz and C.Y. Chiang, Effects of certain abused drugs on hemolysin forming cells, Life Sci., 17: 1763 (1975).PubMedCrossRefGoogle Scholar
- 10.E. Tubaro, G. Borelli, C. Croce, G. Cavallo, and C. Santiangeli, Effect of morphine on resistance to infection, J. Infect. Dis., 148: 656 (1983).PubMedCrossRefGoogle Scholar
- 11.D.T. Lysle, M.E. Coussons, V.J. Watts, E.H. Bennett, and L.A. Dykstra, Morphine-induced alterations of immune status: Dose-dependency, compartment specificity, and antagonism by naltrexone, J. Pharm. Exp. Ther., 265: 1071 (1993).Google Scholar
- 12.B.M. Bayer, S. Daussin, M. Hernandez, and L. Irvin, Morphine inhibition of lymphocyte activity is mediated by and opioid-dependent mechanism, Neuropharm., 29: 369 (1990).CrossRefGoogle Scholar
- 13.J.P. Ehrlich and G.R. Burleson, Enhanced and prolonged pulmonary influenza virus infection following phosgene inhalation, J. Toxicol. and Environ. Health, 34: 259 (1991).CrossRefGoogle Scholar
- 14.K. Gylires, I. Budavari, S. Fürst, and I. Molnar. Morphine inhibits the carrageenan-induced oedema and the chemoluminescence of leucocytes stimulated by zymosan, J. Pharm. Pharmacol., 37: 100 (1985).CrossRefGoogle Scholar
- 15.P. Sacerdote, M. Bianchi, and A.E. Panerai, Involvement of B-endorphin in the modulation of paw inflammatory edema in the rat, Reg. Peptides, 63: 79 (1996).CrossRefGoogle Scholar
- 16.D. H. Broide, Inflammatory Cells: Structure and Function, in Basic and Clinical Immunology, D.P., Stiles and A.I. Terr Eds., Appleton and Lange, Norwalk (1991).Google Scholar
- 17.R.J. Weber and A. Pert, The periaqueductal grey matter mediates opiate-induced immunosuppression, Science, 245: 188 (1989).PubMedCrossRefGoogle Scholar
- 18.P.J. Cabot, T. Crammond, and M.T. Smith, Quantitative autoradiography of peripheral opioid binding sites in rat lung, Euro. J. Pharm., 310: 47 (1996).CrossRefGoogle Scholar
- 19.P.J. Cabot, P.R. Dodd, T. Crammond, and M.T. Smith, Characterization of non-conventional opioid binding sites in rat and human lung, Euro. J. Pharm., 268: 247 (1994).CrossRefGoogle Scholar
- 20.H. Lebrec, K. Sarlo, and G.R. Burleson, Effect of influenza virus infection on ovalbumin-specific IgE responses to inhaled antigen in the rat, J. Toxicol. Environ. Health, 49: 619 (1996)PubMedCrossRefGoogle Scholar
- 21.J.P. Ehrlich, A.F. Gunnison, and G. R. Burleson, Influenza virus-specific cytotoxic T-lymphocyte activity in Fischer 344 rat lungs as a method to assess pulmonary immunocompetence: Effect of phosgene inhalation, Inhal. Toxicol., 1: 129 (1989).CrossRefGoogle Scholar
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