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Immunomodulation of Macrophage Functions by Opioids

  • Chapter
Drugs of Abuse, Immunomodulation, and Aids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 437))

Abstract

Opioid agonists represent a group of natural, semisynthetic, or synthetic drugs with the ability to relieve pain but with the potential risk to provoke physical dependence. Structurally, opioids are phenanthrene derivatives (morphine), phenypiperidine derivatives (fentanyl), diphenylheptane derivatives (methadone),1 and pep tide-related compounds (en- dorphin, enkephalin, and dynorphin).2 Opioids exert their major pharmacologic effect on the central nervous system, however, they also interact with the immune system by altering macrophage, natural killer (NK) cell, and lymphocyte functions, thus impairing immunity against infectious diseases and cancer.3-7 Opioid agonist activities depend on binding to high-affinity receptors named μ, k, and δ which been found on cells of the immune system.2.8-10

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Authors and Affiliations

  1. Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, Peoria, Illinois, 61656-1649, USA

    Ricardo Gomez-Flores & Richard J. Weber

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  1. Ricardo Gomez-Flores
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  2. Richard J. Weber
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  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Herman Friedman  & Thomas W. Klein  & 

  2. Emory University, Atlanta, Georgia, USA

    John J. Madden

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Gomez-Flores, R., Weber, R.J. (1998). Immunomodulation of Macrophage Functions by Opioids. In: Friedman, H., Madden, J.J., Klein, T.W. (eds) Drugs of Abuse, Immunomodulation, and Aids. Advances in Experimental Medicine and Biology, vol 437. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5347-2_2

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