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Three Modes of Calcium-Induced Calcium Release (CICR) in Neurons

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Information Processing in Cells and Tissues

Abstract

Ca2+ is an important signaling ion in a wide variety of cells, and many physiological stimuli produce their cellular effects by changing the intracellular free Ca2+ concentration ([Ca2+]) (Clapham, 1995, Berridge, 1995). Given that cells are multicompartment systems, the action of a particular stimulus depends on the way it modifies intracompartmental [Ca2+], and the Ca2+-sensitive effectors that are present within each compartment, poised to interpret the Cat+ signal. Since [Ca2+] is regulated by multiple interacting Ca2+ transport pathways, understanding the effects of stimulation on the intracellular distribution of Ca2+ requires analysis of the dynamical properties of a system of coupled Ca2+ transporters.

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© 1998 Springer Science+Business Media New York

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Friel, D.D. (1998). Three Modes of Calcium-Induced Calcium Release (CICR) in Neurons. In: Holcombe, M., Paton, R. (eds) Information Processing in Cells and Tissues. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5345-8_6

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  • DOI: https://doi.org/10.1007/978-1-4615-5345-8_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7438-1

  • Online ISBN: 978-1-4615-5345-8

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