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Dementia with Lewy Bodies

A New Avenue for Research into Neurobiological Mechanisms of Consciousness?
  • Robert H. Perry
  • Matthew Walker
  • Elaine K. Perry
Part of the Advances in Behavioral Biology book series (ABBI, volume 49)

Abstract

The term consciousness is generally applied medically with reference to the level of consciousness apparent to the observer-awake or comatose/unrousable with varying degrees between, or with reference to general anaesthesia. Far less consideration has been given, in the past, to the subjective experience of conscious awareness. However, consciousness is rapidly emerging as a subject of intense scientific enquiry. Innumerable books have been published within the last decade and international meetings are becoming abundant.

Keywords

Lewy Body Dementia With Lewy Body Visual Hallucination Conscious Awareness Paradoxical Sleep 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albin, R.L., Minoshima, S., D’Amato, C.J., Frey, K.A., Kuhl, D.A., and Sima, A.A.F., 1996, Fluorodeoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology 47:462–466.PubMedCrossRefGoogle Scholar
  2. Baars, B.J., 1993, How does a serial integrated and very limited stream of consciousness emerge from a nervous system that is mostly unconscious, distributed, parallel and of enormous capacity? In: Experimental and theoretical studies of consciousness, Broch, G., and Marsh, J., eds, New York. Wiley.Google Scholar
  3. Ballard, C., Lowery, K., and Harrison, R., 1996, Noncognitive symptoms in Lewy body dementia. In: Dementia with Lewy bodies, Perry, R.H., McKeith, I.G., and Perry, E.K., eds, Cambridge. Univ. Press, Cambridge, 67–84.CrossRefGoogle Scholar
  4. Ballard, C.G., Saad, K., Patel, A., Gahir, M., Solis, M., Coope, B., and Wilcock, G., 1995, The prevalence and phenomenology of psychotic symptoms in dementia sufferers. Int. J. Geriatr. Psychiatry. 10:477–486.CrossRefGoogle Scholar
  5. Bogen, J.E., 1995, On the neurophysiology of consciousness: 1. An overview, Consciousness Cogn. 4:52–62.CrossRefGoogle Scholar
  6. Court, J.A., and Perry, E.K., 1995, Nicotinic receptor distribution in the CNS, In: Stone, T.W., ed, CNS neuro-transmitters and neuromodulators-acetylcholine, CRC Press. Boca Raton. pp85–104.Google Scholar
  7. Cummings, J.L., and Kaufer, D., 1996, Neuropsychiatric aspects of Alzheimer’s disease: The cholinergic hypothesis revisited. Neurology. 47:876–883.PubMedCrossRefGoogle Scholar
  8. Delacour, J., 1997, Neurobiology of consciousness. Behav. Brain. Res. 85:127–141.PubMedCrossRefGoogle Scholar
  9. Donnemiller, E., Heilman, J., Wenning, G.K., Berger, W., Decristoforo, C., Moncayo, R., Poewe, W., and Rans-mayr, G., 1997, Brain perfusion scintigraphy with 99mTC-HMPAO or 99mTC-ECD and l23I-β-CIT single-photon-emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease. Eur. J. Nucl. Med. 24:320–325.PubMedGoogle Scholar
  10. Everitt, B.J., and Robbins, T.W., 1997, Central cholinergic systems and cognition. Annu. Rev. Psychol. 48: 649–684.PubMedCrossRefGoogle Scholar
  11. Flood, P., Ramirez-Latorre, J., and Role, L., 1997, α4β2 Neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but β7-type nicotinic acetylcholine receptors are unaffected. Anesthesiology. 86:859–865.PubMedCrossRefGoogle Scholar
  12. Forstl, H., Burns, A., Levy, R., and Cairns, C., 1994, Neuropathologic correlates of psychotic phenomena in confirmed Alzheimer’s disease. J. Psychiatr. 165:53–59.CrossRefGoogle Scholar
  13. Heckers, S., Geula, C., and Mesulam, M.M., 1992, Cholinergic innervation of the human thalamus: dual origin and differential nuclear distribution. J. Comp. Neuroi. 325:68–82.CrossRefGoogle Scholar
  14. Hesslow, G., 1994, Will neuroscience explain consciousness? J. Theoret. Biol. 17:29–39.CrossRefGoogle Scholar
  15. Hobson, J.R., 1988, The Dreaming Brain. Penguin Books, Cox and Wyman Ltd, Reading.Google Scholar
  16. Hobson, J.A., Lydic, R., and Baghdogan, H.A., 1986, Evolving concepts of sleep cycle generation: from brain centres to neuronal populations. Science. 189:55–58.CrossRefGoogle Scholar
  17. Hobson, J.A., 1996, How the brain goes out of its mind. Endeavour. 20(2):86–9.PubMedCrossRefGoogle Scholar
  18. Hugdahl, K., 1996, Cognitive influences on human antonomic nervous system. Curr. Opin. Neurobiol. 6:252–258.PubMedCrossRefGoogle Scholar
  19. Hutchinson, M., and Fazzini, E., 1996, Cholinesterase inhibition in Parkinson’s disease. J. Neurol. Neurosurg. Psy-chiat. 61:324–325.CrossRefGoogle Scholar
  20. Jasper, H.H., and Tessier, J., 1971, Acetylcholine liberation from cerebral cortex during paradoxical (REM) sleep. Science. 172:601–602.PubMedCrossRefGoogle Scholar
  21. Jones, B.E., 1999, Paradoxical sleep and its chemical/structural substrates in the brain. Neurosci. 40:637–656.CrossRefGoogle Scholar
  22. Jones, B.E., and Webster, H.H., 1988, Neurotoxic lesions of dorsolateral pontomesencephalic tegmentum-choliner-gic cell area in the cat. I. Effects upon the cholinergic innervation of the brain. Brain Res. 451:13–32.PubMedCrossRefGoogle Scholar
  23. Jones, B.E., and Webster, H.H., 1988, Neurotoxic lesions of dorsolateral pontomesencephalic tegmentum-choliner-gic cell area in the cat. II. Effects upon sleep-waking states. Brain Res. 458:285–302.PubMedCrossRefGoogle Scholar
  24. Karczmar, A.G., Longo, V.G., and Scoti de Carolis, A., 1970, A pharmacological model of paradoxical sleep: the role of cholinergic and monoaminergic systems. Physiol. Behav. 5:175–182.PubMedCrossRefGoogle Scholar
  25. Klatka, L.A., Louis, E.D., and Schiffer, R.B., 1996, Psychiatric features in diffuse Lewy body disease: a clinico pathologic study using Alzheimer’s disease and Parkinson’s disease comparison groups. Neurology. 47:1148–1152.PubMedCrossRefGoogle Scholar
  26. Louis, E.D., Klatka, L.A., Liv, Y., and Fahn, S., 1997, Comparison of extrapyramidal features in 31 pathologically confirmed cases of diffuse Lewy body disease and 34 pathologically confirmed cases of Parkinson’s disease. Neurology. 48:376–380.PubMedCrossRefGoogle Scholar
  27. McKeith, I.G., Perry, R.H., Fairbairn, A.F., Jabeen, S., and Perry, E.K., 1992, Operational criteria for senile dementia of Lewy body type (SDLT). Psychol. Med. 22:911–922.PubMedCrossRefGoogle Scholar
  28. McKeith, I.G., Galasko, D., Kosaka, K., Perry, E.K., Dickson, D.W., Hansen, L.A., Salmon, D.P., Lowe, J., Mirra, S.S., Byrne, E.J., Lennox, G., Quinn, N.P., Edwardson, J.A., Ince, P.G., Bergeron, C., Burns, A., Miller, B.L., Lovestone, S., Collerton, D., Jansen, E.N., Ballard, C., de Vos, R.A., Wilcock, G.K., Jellinger, K.A., and Perry, R.H., 1996, Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB). Neurology. 47:113–1124.CrossRefGoogle Scholar
  29. McKeith, I.G., Perry, R.H., Fairbairn, A.F, and Perry, E.K., 1992, Neuroleptic sensitivity in patients with senile dementia of Lewy body type. Brit. Med. J. 305:673–678.PubMedCrossRefGoogle Scholar
  30. Marty, S., de Penha Berzaghi, M., and Berninger, B., 1997, Neurotrophins and activity dependant plasticity of cortical intemeurons. Trends. Neurosci. 20:198–202.PubMedCrossRefGoogle Scholar
  31. Mitrofanis, J., and Guillery, R.W., 1993, New views of the thalamic reticular nucleus in the adult and developing brain. Trends. Neurosci. 13:1719–1729.Google Scholar
  32. Newman, J., and Baars, B.J., 1993, A neural attentional model for access to consciousness. A global workspace perspective. Concepts Neurosci. 4:255–290.Google Scholar
  33. Pare, D., and Llinas, R., 1995, Conscious and pre-conscious processes as seen from the stand point of sleep-waking cycle neurophysiology. Neuropsychologia 33:1155–1168.PubMedCrossRefGoogle Scholar
  34. Perry, E.K., and Perry, R.H., 1995, Acetycholine and hallucinations, disease-related compared to drug-induced alterations in human consciousness. Brain and Cognition 28:240–258.PubMedCrossRefGoogle Scholar
  35. Perry, E.K., and Perry, R.H., 1996, Altered consciousness and transmitter signalling in Lewy body dementia. In: Dementia with Lewy bodies, Perry, R.H., McKeith, I.G., Perry, E.K., eds, pp. 397–413, Cambridge. Univ. Press, Cambridge.CrossRefGoogle Scholar
  36. Perry, E.K., Smith, C.J., Court, J.A., and Perry, R.H., 1990, Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types. J Neural. Transm. 27:149–158.Google Scholar
  37. Perry, E.K., Haroutunian, V., Davis, K.L., Levy, R., Lantos, P., Eagger, S., Honavar, M., Dean, A., Griffiths, M., McKeith, I.G., and Perry. R.H., 1994, Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer’s disease. Neuroreport 55:1454–1456.Google Scholar
  38. Perry, E.K., Morris, C.M., Court. J.A., Cheng, A., Fairbairn, A., McKeith, I.G., Irving, D., Brown, A., and Perry, R.H., 1995, Alteration in nicotine binding sites in Parkinson’s disease, Lewy body dementia and Alzheimer’s disease: possible index of early neuropathology. Neuroscience 64:385–395.PubMedCrossRefGoogle Scholar
  39. Perry, R.H., Irving, D., Blessed, G., Fairbairn, A., and Perry, E.K., 1990, Senile dementia of Lewy body type: a clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J. Neuroi Sci. 95:119–135.CrossRefGoogle Scholar
  40. Perry, R.H., McKeith, I.G., and Perry, E.K., 1997, Lewy body dementia: clinical, pathological and neurochemical interconnections. J. Neural Trans. PD and Dementia Sect Suppl 4, in press.Google Scholar
  41. Postle, B.R., Corkin, S., and Growdon, J.H., 1996, Intact implicit memory for novel patterns in Alzheimer’s disease. Learn. Mem. 3:305–312.PubMedCrossRefGoogle Scholar
  42. Reikinen, P., Sirvio, J., Hannila, T., Miettinen, R., and Riekkinen, P., 1990, Effects of quisqualic acid nucleus basalis lesioning on cortical EEG, passive avoidance and water maze performance. Brain. Res. Bull. 24:839–842.CrossRefGoogle Scholar
  43. Sarter, M., and Bruno, J.P., 1997, Cognitive functions of cortical acetylcholine: towards a unifying hypothesis. Brain. Res. Revs. 23:28–46.CrossRefGoogle Scholar
  44. Schebeil, A.B., 1980, Anatomical and physiological substrates of arousal: a view from the bridge. In: Reticular formation revisited, Hobson, J.A., and Brazier, M.A., eds, New York: Raven Press,, pp. 55–66.Google Scholar
  45. Schmidt, B.H., Fanelli, R.J., and van der Staay, F.J., Preclinical pharmacology of metrifonate: an overview (this book).Google Scholar
  46. Scott, L.C., Wright, G.K., Rai, G.S., Exton-Smith, A.N., and Gardiner, J.M., 1991, Further evidence of preserved memory function in Alzheimer’s disease. Int. J. Geriatr. Psychiat. 6:583–588.CrossRefGoogle Scholar
  47. Steriade, M., and Llinas, R.R., 1988, The functional states of the thalamus and the associated neuronal interplay. Physiol. Rev. 68:649–742.PubMedGoogle Scholar
  48. Steriade, M., and McCarley, R.W., 1990, Brainstem control of wakefulness and sleep. Plenum, New York.Google Scholar
  49. Steriade, M., Curro Dossi, D., Pare, D., and Oakson, G., 1991, Fast oscillations (2O-4OHz) in the thalamocortical systems and their potentiation by mesopontine cholinergic nuclei in the cat. Proc. Nat. Acad. Sci. USA. 88:4396–4400.PubMedCrossRefGoogle Scholar
  50. Tokimasa, A., and Yamadori, A., 1997, Procedural memory in patients with mild Alzheimer’s disease. Dement. Geriatr. Cogn. Disord. 8:210–216.PubMedCrossRefGoogle Scholar
  51. Newman, J., 1995, Thalamic contributions to attention and consciousness. Consciousness and Cognition. 4:172–93.PubMedCrossRefGoogle Scholar
  52. Turner, B.H., and Knapp, M.E., 1995, Consciousness a neurobiological approach. Integr. Physiol. Behav. Sci.. 30:151–156.PubMedCrossRefGoogle Scholar
  53. Vanderwoolf, C.H., Fine, A., and Cooley, R.K., 1990, Intracortical grafts of embryonic basal forebrain tissue restore low voltage fast activity in rats with basal forebrain lesions. Exp. Brain. Res. 81:426–432.CrossRefGoogle Scholar
  54. Violet, J.M., Downie, D.L., Nakinsa, R.C., Lieb, W.R., and Franks, N.P., 1997, Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anaesthetics. Anesthesiology. 86:866–874.PubMedCrossRefGoogle Scholar
  55. Wenk, G.L., 1997, The nucleus basalis magnocellularis cholinergic system. One hundred years of progress. Neuro-biol. Learn. Mem. 67:85–95.CrossRefGoogle Scholar
  56. Woolf, N.C., 1991, Cholinergic systems in mammalian brain and spinal cord. Progr. Neurobiol. 37:475–524.CrossRefGoogle Scholar
  57. Zubenko, G.S., Moossy, J., Martinez, J., Rao, G., Claassen, D., Rosen, J., and Kopp, U., 1991, Neuropathologic and neurochemicat correlates of psychosis in primary dementia. Arch. Neurol. 48:619–624.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Robert H. Perry
    • 1
  • Matthew Walker
    • 2
  • Elaine K. Perry
    • 2
  1. 1.Department of NeuropathologyUSA
  2. 2.MRC Neurochemical Pathology UnitNewcastle General HospitalNewcastle upon TyneUK

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