Abstract
Behavioral changes, mood-related disturbances and sleep disorders are the major cause of institutionalization and caregiver concern in families with Alzheimer’s disease (AD) (Rabins et al., 1982; Steele et al., 1990; Morris et al., 1996). The estimated prevalence of psychiatric symptoms in AD accounts for 40–60% of the cases (Ballard et al., 1995). Psychiatric symptoms are associated with lower total MMSE scores (Cooper et al., 1990) and overall cognitive deterioration (Drevets et al., 1989; Forstl et al., 1993). In general, psychotic symptoms run in parallel with an accelerated cognitive deterioration, in some cases partially induced by psychotropic drugs. In many other cases, behavioral changes do not seem to be associated with exogenous factors. Psychotic symptoms, especially delusions, hallucinations and misidentifications, are positively correlated with agressive behavior and institutionalization (Deutsch et al., 1991). Agitation and wandering are also associated with rapid cognitive decline in dementia (Tinklenberg et al., 1990).
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Sellers, A. et al. (1998). Cognitive and Non-Cognitive Symptoms in Senile Dementia. In: Fisher, A., Hanin, I., Yoshida, M. (eds) Progress in Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5337-3_44
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DOI: https://doi.org/10.1007/978-1-4615-5337-3_44
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