Abstract
James Parkinson in 1817 in his famous Essay on the Shaking Palsy described the “involuntary tremulous motion, with lessened muscular power, in parts not in action and even when supported; with a propensity to bend the trunk forwards, and to pass from a walking to a running pace: the senses and intellects being uninjured” (Parkinson, 1817). Indeed the possibility that PD is associated with dementia has been negated by neurologists for several decades. It should be mentioned that antedating levodopa therapy patients could not be formally cognitively tested because of their motor disability, bradyphrenia and speech impairment. There was also a tendency to attribute dementia in old age (and the great majority of PD patients are aged) to concurrent “senility” or “cerebral aterosclerosis” Once levodopa and dopa-agonist therapy was instituted this situation, surprisingly, did not change and the impression emerged that dementia is common in PD, more so in patients with advanced PD (Korczyn et al., 1986). Since then, overwhelming proof has accumulated that PD is accompanied by dementia in at least 20% of the cases. The debate over the issue of coincidental AD in demented PD patients is still not entirely resolved since some of the clinical and pathological features of the two dementias are similar.
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References
American Psychiatric Association, 1994, Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Washigton D.C.
Asherov, A., Chapman, J., Kipperwasser, S., Inzelberg, R., and Korczyn, A.D., 1995, Apo E haplotype in Parkinson’s disease and its relation to dementia. Neurology 45:(suppl 4):A340.
Benjamin, R., Leake, A., Edwardson, J.A., McKeith, LG., Ince, P.G., Perry, R.H., and Morris, C.M., 1994, Apolipoprotein E genes in Lewy body and Parkinson’s diseases. Lancet 343:1565.
Corder, E.H., Saunders, A.M., Strittmatter, W.J., Schmechel, D.E., Gaskell, P.C., Small, G.W., Roses, A.D., Haines, J.L., and Pericak, Vance M.A., 1993, Gene dose of apolipoprotein E type 4 allele and risk of Alzheimer’s disease in late onset families. Science 261:921–923.
Galasko, D., Saitoh, T., Xia, Y., Thal, L.J., Katzman, R., Hill, L., and Hansen, L., 1994, The apolipoprotein E allele e4 is overrepresented in patients with the Lewy body variant of Alzheimer’s disease. Neurology 44:1950–1951.
Growdon, J.H., Locascio, J.J., Corkin, S., Gomez-Isla, T., and Hyman, B.T., 1996, Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer’s disease. Neurology 47:444–448.
Inzelberg, R., Chapman, J., Treves, T.A., Kipperwasser, S., Orlov, E., Klimovitzky, S, Verchovsky, R., and Korczyn, A.D., 1997, Apolipoprotein E4 in Parkinson’s disease and dementia: New data and meta-analysis of published studies. Alz. Dis Assoc Disord (in press).
Jellinger, K, 1986, Overwiev of morphological changes in Parkinson’s disease. In: Advances in Neurology, vol 45, Yahr, M.D. and Bergman, K.J., ed., Raven Press, New York, pp 1–18
Koller, W.C., Glatt, S.L., Hubble, J.P., Paolo, A., Troster, A.I., Handler, M.S., Horvat, R.T., Martin, C., Schmidt, K., and Konst, A., 1995, Apolipoprotein E genotypes in Parkinson’s disease with and without dementia. Ann Neurol 37:242–245.
Korczyn, A.D., Inzelberg, R., Treves, T. A., Neufeld, M. Y, Reider, I., and Rabey, M.J., 1986, Dementia of Parkinson’s Disease. In: Advances in Neurology, vol 45, Yahr, M.D. and Bergman, K.J., Raven Press, New York pp 399-403.
Korczyn, A.D., 1995, The apolipoprotein e4 allele in Parkinson’s disease with and without dementia., (letter) Neurology 45:1025.
Kurz, A., Egensperger, R., Haupt, M., Lautenschlager, N., Romero, B., Graeber, M.B., and Muller, U., 1996, Apolipoprotein E e4 allele, cognitive decline and deterioration of everyday performance in Alzheimer’s disease. Neurology 47:440–443.
Marder, K., Maestre, G., Cote, L., Mejia, H., Alfaro, B., Halim, A., Tang, M., Tycko, B., and Mayeux, R., 1994, The apolipoprotein e4 allele in Parkinson’s disease with and without dementia. Neurology 44:1330–1331.
Parkinson, J., 1817, An Essay on the Shaking Palsy. London. Sherwood, Neely and Jones.
Pickering-Brown, S.M., Mann, D.M.A., Bourke, J.P., Roberts, D.A., Balderson, D., Burns, A., Byrne, J., and Owen, F., 1994, Apolipoprotein e4 and Alzheimer’s disease pathology in Lewy body disease and in other (-amyloid forming diseases. Lancet 343:1155–1158.
Plassman, B.L., and Breitner, J.C.S., 1996, Apolipoprotein E and cognitive decline in Alzheimer’s disease. Neurology 47:317–320.
Polvikoski, T., Sulkava, R., Haltia, Kainulainen, K, Vuorio, A., Verkkoniemi, A., Niinisto, L., Halonen, R., and Kontula K, 1995, Apolipoprotein E, dementia and cortical deposition of β-amyloid protein. N. Engl. J. Med. 333:1242–1247.
Roses, A.D., 1996, Apolipoprotein E alleles as risk factors in Alzheimer’s disease. Ann. Rev. Med. 47:387–400.
Rubinszstein, D.C, Hanlon, C.S., Irving, R.M., Goodburn, S., Evans, D.G., Kellan-Wood, H., Huereb, J.H., Band-mann, O., and Harding, A.E., 1994, Apo E genotypes in multiple sclerosis, Parkinson’s disease, Schwanomas and late onset Alzheimer’s disease. Mol. Cell Probes 8:519–525.
Saunders, A.M., Strittmatter, W.J., Schmechel, D., St. George Hyslop, P.H., Pericak, Vance M.A., Rosi, B.C., Gusella, J.F., Crapper, Mac Lachlan, D.R., Alberts, M.J., Hullette, C., Crain, B., Goldgaber, D., Roses, A.D., 1993, Association of apolipoprotein E allele e4 with late onset familial and sporadic Alzheimer’s disease. Neurology 43:1467–1472.
Schupf, N., Kapell, D., Lee, J.H., Zigman, W., Canto, B., Tycko, B., and Mayeux, R., 1996, Onset of dementia associated with apolipoprotein E ε4 in Down syndrome. Ann. Neurol. 40:799–801.
Treves, T. A., Ragolsky, M., Gelernter, I., and Korczyn, A.D., 1990, Evaluation of a short mental test for the diagnosis of dementia. Dementia 1:102–108.
Treves, T.A., Bornstein, N.M., Chapman, J., Klimovitzky, S., Verchovsky, R., Asherov, A., Veshchev, I.O., and Korczyn AD, 1996, APOE epsilon 4 in patients with Alzheimer’s disease and vascular dementia. Alz. Dis. Assoc. Disord. 10:189–191.
Wenham, P.R., Price, W.H., and Blundel, G., 1991, Apolipoprotein E genotyping by one-stage PCR. Lancet 337:1158–1159.
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Paleacu, D., Inzelberg, R., Chapman, J., Orlov, E., Asherov, A., Korczyn, A.D. (1998). Apolipoprotein E ε4 Allele Does Not Influence the Development of Dementia in Parkinsonian Patients. In: Fisher, A., Hanin, I., Yoshida, M. (eds) Progress in Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5337-3_117
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DOI: https://doi.org/10.1007/978-1-4615-5337-3_117
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