Abstract
In 1936 Szemt-Guörgi proposed the name of Vitamin P for a mixture of two flavonoids that decreased capillary permeability and fragility in humans and thus began the research on flavonoids and health (Rusznyak and Szent-Györgi, 1936). The flavonoids have been reported to exhibit a wide range of biological effects in animals and man that include antibacterial, antiviral, antiinflammatory, antiallergic, and vasodilatory actions. In addition, flavonoids inhibit lipid peroxidation, protein modification of collagen by peroxynitrite, platelet aggregation, and the activity of enzyme systems including phospholipase A2, glutathione reductase, xanthine oxidase, cyclooxygenase and lipoxygenase (Harborne, 1986).
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References
Acheson, R.M.; Williams, D.R.R. Does consumption of fruit and vegetables protect against stroke? Lancet 1983, 1, 1191–1193.
Ameer, B.; Weintraub, R.A.; Johnson, J.V.; Yost, R.A.; Rouseff, R.L. Flavone absorption after naringin, hesperidin, and citrus administration. Clin. Pharmacol Then 1996, 60, 34–40.
Armstrong.; B.K.; Mann, J.I.; Adelstein, A.M.; Eskin, F. Commodity consumption and ischemic heart disease mortality, with special reference to dietary practices. J. Chron. Dis. 1975, 28, 455–469.
Ascherio, A.; Rimm., E.B.; Giovannucci, E.L.; Colditz, G.A.; Rosner, B.; Willett, W.C.; Sacks, F.; Stampfer, M.J.A. A prospective study of nutritional factors and hypertension among US men. Circulation 1992, 86, 1475–1484.
Cao, G.; Sofic, E.; Prior, R.L. Antioxidant capacity of tea and common vegetables. J. Agric. Food Chem. 1996, 44, 3426–3421.
Cook, D.G.; Carey, I.M.; Walker, M. Effect of fresh fruit consumption on lung function and wheeze in children. Thorax 1997, 52, 628–633.
Criqui, M.H.; Ringel, B. Does diet or alcohol explain the French Paradox? Lancet 1994, 344, 1719–1723.
Esterbauer, H.; Gebicki, J.; Puhl, H.; Jürgens, G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad. Biol. Med. 1992, 13, 341–390.
Frei, B. C. Cardiovascular disease and nutrient antioxidants: role of low-density lipoprotein oxidation. Crit. Revs. Food Sci. Nutr. 1995, 35, 83–97.
Fuhrman, B.; Lavy, A.; Aviram, M. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am. J. Clin. Nutr. 1995, 61, 549–554.
Gillman, M.W.; Cupples, L.A.; Gangnon, D.; Posner, B.M.; Ellison, R.C.; Castelli, W.P.; Wolf, P.A. Protective effect of fruits and vegetables on development of stroke in men. 1995, J. Am. Med. Assoc. 1995, 273, 1113–1117.
Grønbaek, M.; Deis, A.; Sørensen, T.I.A.; Becker, U.; Schnohr, P.; Jensenen, G. Mortality associated with moderate intakes of wine, beer or spirits. Br. Med. J. 1995, 510, 1165–1169.
Harborne, J.B. Nature, distribution and function of plant flavonoids. In Plant Flavonoids in Biology and Medicine; Cody, V., Middleton, E. Harborne J.B. Eds.; Liss, New York, 1986, p. 15–24.
He, Y.H.; Kies, C. Green and black tea consumption by humans; impact on polyphenol concentrations in feces, blood and urine. Plant Foods Hum. Nutr. 1994, 46, 221–229.
Hertog, M.G.L.; Hollman, P.C.H.; Katan, M.B. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem. 1992, 40, 2379–2383.
Hertog, M.G.L.; Feskens, E.J.M.; Hollman, P.C.H.; Katan, M.B.; Kromhout, D. Dietary antioxidant flavonoids and risk of coronary heart disease; the Zuphen elderly study. Lancet 1993a, 342, 1007–1011.
Hertog, M.G.L.; Hollman, P.C.H.; van de Putte, B. Content of potentially anticarcinogenic flavonoids of tea infusion, wines and fruit juices. J. Agric. Food Chem. 1993b, 41, 1242–1246.
Hertog, M.G.L.; Kromhout, D.; Aravanis, C; Blackburn, H.; Buzina, R.; Fidanza, F.; Giampaoli, S.; Jansen, A.; Menotti, A.; Nedeljkovic, S.; Pekkarinen, M.; Bozida, S.S.; Toshima, H.; Feskens, E.J.M.; Hollman, P.C.H.; Katan, M.B. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Int. Med. 1995, 155, 381–386.
Hollman, P.C.H.; Gaag, M.V.D.; Mengelers, M.J.B.; van Trijp, J.M.P.; de Vries, J.H.M.; Katan, M.B. Absorption and disposition kinetics of the dietary antioxidant quercetin in man, Free Rad. Biol. Med. 1996, 21, 703–707.
Hollman, P.C.H.; de Vries, J.H.M.; van Leeuwen, S.D.; Mengelers, M.J.B.; Katan, M.B. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am. J. Clin. Nutr. 1995, 62, 1276–1282.
Ishikawa, T.; Suzukawa, M.; Toshimitsu, I.; Yoshida, H.; Ayaori, M.; Nishiwaki, M.; Yonemura, A.; Hara, Y; Nakamura, H. Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am. J. Clin. Nutr. 1997, 66, 261–266.
Jovanovic, S.V.; Steenken, S.; Hara, Y; Simic, M.G. Reduction potential of flavonoid and model phenoxyl radicals. Which ring in flavonoids is responsible for antioxidant activity? J. Chem. Soc. Perkin Trans. 2 1996, 2497–2504.
Keli, S.O.; Hertog, M.G.L.; Feskens, E.J.M.; Kromhout, D. Dietary flavonoids, antioxidant vitamins, and incidence of stroke. Arch. Int. Med. 1996, 156, 637–642.
Knekt, P.; Järvinen, R.; Reunanen, A.; Maatela, J. Flavonoid intake and coronary mortality in Finland; a cohort study. Br. Med. J. 1996, 312, 478–481.
Kiihnau, J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Dietet. 1916, 24, 117–191.
Leibovitz, B.E. Polyphenols and bioflavonoids: the medicines of tomorrow. Nutr. Update 1992, 6, 1–13.
Lee, M.-J.; Wang, Z.-Y; Li, H.; Chen, L.; Sun, Y; Gobbo, S.; Balentine, D.A.; Yang, C.S. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol. Biomarkers Prev. 1995, 4, 393–399.
Maiani, G.; Serafini, M.; Salucci, M.; Azzini, E.; Ferro-Luzzi, A. Application of a new high-performance liquid chromatographic method for measuring selected polyphenols in human plasma. J. Chromatog. B 1997, 692, 311–317.
Maxwell, S.; Cruickshank, A.; Thorpe, G. Red wine: antioxidant activity in serum. Lancet 1994, 344, 193.
Middleton, E.; Kandaswami, C. The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In The Flavonoids: Advances in Research since 1986, Ed. Harborn, J.B., Chapman and Hall, London, p. 619–652.
Nakagawa, K.; Miyazawa, T. Chemiluminescence high-performance liquid chromatographic determination of tea catechin, (−)-epigallocatechin 3-gallate, at picomole levels in rat and human plasma. Anal Biochem. 1997, 248, 41–49.
Nielsen, S.E.; Kall, M.; Justesen, U.; Schou, A.; Dragsted, L.O. Human absorption and excretion of flavonoids after broccoli consumption. Cancer Lett., 1997, 114, 173–174.
Paganga, G.; Rice-Evans, C.A. The identification of flavonoids as glycosides in human plasma. FEBS Lett. 1997, 401, 78–82.
Renaud. S.; de Lorgeril, M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992, 339, 1523–1526.
RiceEvans, C.; Miller, N.J.; Antioxidants-the case for fruits and vegetables in the diet. Br. Food J. 1995, 97, 35–40.
Rimm, E.B.; Katan, M.B.; Ascherio, A.; Stampfer, M.J.; Willett, W.C. Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann. Intern. Med. 1996, 125, 384–389.
Ruf, J.-C.; Berger, J.-L.; Renaud, S. Platelet rebound effect of alcohol withdrawn and wine drinking in rats. Relation to tannins and lipid peroxidation. Arteriosler. Thromb. Vase. Biol. 1995, 15, 140–144.
Rusznyàk, S.; Szent-Györgi, A. Viamin P; flavonols as vitamins. Nature 1936, 138, 27.
Satué-Gracia; Heinonen, M.; Frankel, E.N. Anthocyanins as antioxidants on human low-density lipoprotein and lecithin-liposome systems. J. Agric. Food Chem. 1997, 45, 3362–3367.
Serafini, M.; Ghiselli, A.; Ferro-Luzzi, A. Red wine, tea, and antioxidants. Lancet 1994, 344, 626.
Serafini, M.; Ghiselli, A.; Ferro-Luzzi, A. In vivo antioxidant effect of green and black tea in man. Eur. J. Clin. Nutr. 1996, 50, 28–32.
Serafini, M.; Maiani, G.; Ferro-Luzzi, A. Effect of alcohol on red wine tannin-protein (BSA) interactions. J. Agric. Food Chem. 1997, 45, 3148–3154.
Shahid, F.; Wanasundara. Phenolic antioxidants. Crit. Rev. Food Sci. Nutr. 1992, 32, 67–103.
Singh, R.B.; Niaz, A.M.; Ghosh, S.; Agarawal, P.; Shmad, S.; Begum, R.; Nuchi, Z.; Kummerow, F.A. Randomized, controlled trial of antioxidant vitamins and cardiprotective diet on hyperlipidemia, oxidative stresss, and development of experimental atherosclerosis: the diet and antioxidant trial on atherosclerosis. Cardiovasc. Drugs Ther. 1995, 9, 763–771.
St Léger, S., Cochrane, A.L.; Moore, F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1979, 12, 1017–1020.
Steinberg, D.; Parathasarathy, S.; Carew, T.E.; Khoo, J.C.; Witzum, J.L. Beyond cholesterol; modification of lowdensity lipoprotein that increases its atherogenicity. New Engl. J. Med. 1989, 320, 915.
Subar A.; Heimendinger, J.; Krebs-Smith, S.; Patterson, B.; Keller-Pivonka, E. 5 A Day for Better Health: A Baseline Study of American Fruits and Vegetable Consumption. National Cancer Institute, Washington, D.C., 1992.
Unno, T.; Kondo, K.; Itakura, H.; Takeo, T. Analysis of (−)-epigallocatechin gallate in human serum obtained after ingesting green tea. Biosci. Biotech. Biochem. 1996, 60, 2066–2068.
Vinson, J.A.; Hontz, B.A. Phenol antoxidant index: comparative antioxidant effectiveness of red and white wines. J. Agric. Food Chem. 1995a, 43, 401–403.
Vinson, J.A.; Dabbagh, Y.A.; Serry, M.M.; Jang, J. Plant polyphenols, especially tea flavonols are powerful antioxidants using an in vitro oxidation model for heart disease. J. Agric. Food Chem. 1995b, 43, 2800–2802.
Vinson, J.A., Jang, J.; Dabbagh, Y.A.; Serry, M.M.; Cai, S. Plant polyphenols exhibit lipoprotein-bound antioxidant activity using an in vitro model for heart disease. J. Agric. Food Chem. 1995c, 43, 2798–2799.
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Vinson, J.A. (1998). Flavonoids in Foods as in Vitro and in Vivo Antioxidants. In: Manthey, J.A., Buslig, B.S. (eds) Flavonoids in the Living System. Advances in Experimental Medicine and Biology, vol 439. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5335-9_11
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DOI: https://doi.org/10.1007/978-1-4615-5335-9_11
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