Abstract
Of the numerous protein kinases present in mammalian cells protein kinase C (PKC) is of particular interest to the field of lipid metabolism because various lipids influence the activation of this enzyme system. These lipid activators include phosphatidylserine, cis-unsaturated fatty acids (arachidonic acid, oleic acid), diacylglycerol, inositol phosphates, fecapentaene, phorbol ester tumor promoters and related compounds, and cholesterol sulfate. The activation of PKC can, in turn influence lipid metabolism by causing feedback inhibition of phospholipase C., activation of phospholipase A2 and activation of phospholipase D (1–6).
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References
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Bernard Weinstein, I. et al. (1997). The Role of Protein Kinase C in Signal Transduction, Growth Control and Lipid Metabolism. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_44
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DOI: https://doi.org/10.1007/978-1-4615-5325-0_44
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