Abstract
Leukotriene B4 (LTB4) is a potent lipid mediator of many inflammatory processes (1,2). In addition, elevated tissue levels of LTB4 have been reported in inflammatory diseases such as psoriasis (3) and inflammatory bowel disease (4). For these reasons, LTB4 antagonists have been developed for the treatment of several inflammatory diseases with the aim of inhibiting LTB4 receptor-mediated neutrophil functions (5–7).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Samuelsson, B. Science 220:568–575, 1983.
Claesson, H-E., Odlander, B. and Jakobsson, P-J., Int. J. Immunopharmacol. 14:441–449, 1992.
Grabbe, J., Czarnetzki, B.M., Rosenbach, T. and Mardin M. J. Invest. Dermatol. 82:477–479, 1984.
Sharon, P. and Stenson, W.F., Gastroenterology 86:453–460, 1984.
Tsai, B.S., Villani-Price, D., Keith, R.H., Zemaitis, J.M., Bauer, R.F., Leonard, R., Djuric, S.W. and Shone, R.L., Prostaglandins 38:655–674, 1989.
Kishikawa, K., Tateishi, N., Maruyama, T., Seo, R., Toda, M. and Miyamoto, T., Prostaglandins 44:261–275, 1992.
Jackson, W.T., Boyd, R.J., Froelich, L.L., Mallett, B.E. and Gapinski, D.M. J. Pharm. Exp. Ther. 263:1009–1014, 1992.
Payan, D.G. and Goetzl, E.J. J. Immunol. 131:551–553, 1983.
Rola-Pleszczynski, M. Immunology Today 6:302–307, 1985.
Godfrey, H.P. Immunology 32:25–31, 1977.
Ng, CF., Sun, F.F., Taylor, B.M., Wolin, M.S. and Wong, P.Y-K., J. Immunol. 147:3096–3103, 1991.
Lin, A.H., Ruppel, P.L. and Gorman, R.R., Prostaglandins 28:837–849, 1984.
Godfrey, H.P., Feng, Z.-H., Mandy, S., Mandy, K., Huygen, K., DeBruyn, J., Abou-Zeid, C., Wiker, H.G., Nagai, S. and Tasaka, H., Infect. Immun. 60:2522–2528, 1992.
Wallenstein, S., Zucker, C.L. and Fleiss, J.L., Circ. Res. 47:1–9, 1980.
Lin, K-T., Strudwick, S., Godfrey, H.P. and Wong, P.Y-K., J. Immunol. Submitted, 1993.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wong, P.YK., Lin, KT., Godfrey, H.P. (1997). LTB4 Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_36
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5325-0_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7430-5
Online ISBN: 978-1-4615-5325-0
eBook Packages: Springer Book Archive