Heterophil Antibody

  • Nevio Cimolai


The definition of “heterophil antibody” could be the source for some controversy. At first glance, the intention would be to have defined a humoral immune response which has evolved as a consequence of infection, but which is not specifically related to an antibody-directed antigenic stimulus from the infecting organism. The definition would then depend upon the inability to define cross-reactive epitopes between germ and the heterophil substrate. Unfortunately, the ability to determine the latter may very well be a function of the limitation of the particular tools which are used. The utility of a heterophil antibody response will depend on the predictive values but such a method could be preferred if the results are timely and if specific diagnostic tests are not available. As the immunology and biochemistry of antibody responses advanced to the molecular level, a greater depth of knowledge might lead to a more precise understanding of antigenic relatedness.


Newcastle Disease Virus Cold Agglutinin Heterophil Antibody Serodiagnostic Test Cold Agglutinin Titre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Nevio Cimolai
    • 1
    • 2
  1. 1.The University of British ColumbiaVancouverCanada
  2. 2.Children’s and Women’s Health Centre of British ColumbiaVancouverCanada

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