Probing The Mechanisms Of Hepatocyte/Fibroblast Interactions

  • Sangeeta Bhatia
Part of the Microsystems book series (MICT, volume 5)


We have demonstrated that variations in tissue function can be achieved by modulation of spatial configuration of co-cultures of hepatocytes and fibroblasts. In Chapter 4 we showed that these differences in function were dependent on the degree of heterotypic interaction that occurred between cell populations. Furthermore, these findings correlated with the observation that hepatocellular islands of a critical size displayed spatial heterogeneity in the pattern of induction of hepatocyte differentiation- i.e. within a given hepatocyte population, hepatocytes close to the heterotypic interface demonstrated increased albumin production as compared to more central hepatocytes. Thus, evidence from markers of both bulk and localized liver-specific function suggested that the heterotypic interface between cell populations was an important determinant of the level of tissue function in the resultant tissue.


Spatial Heterogeneity Tissue Engineer Urea Synthesis Hepatic Differentiation Issue Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Sangeeta Bhatia

There are no affiliations available

Personalised recommendations