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Oligonucleotides Containing the G-Quartet Sequence Motif

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Applications of Antisense Therapies to Restenosis

Part of the book series: Perspectives in Antisense Science ((DARE,volume 3))

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Abstract

Guanine quartet (G-quartet) structures were first observed in the early 1900’s as an annoying propensity of guanosine and its derivatives to form viscous gels at low μM concentrations. The tetrameric arrangement of guanosine in the gels, the G-quartet, was established by fiber diffraction in 1962 (1, 2). The G-quartet is a planar array of four hydrogen-bonded guanine bases (Figure 1). Helical quadraplex structures, stabilized by G-quartets, are formed when several G-quartets stack upon each other.

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Author information

Authors and Affiliations

  1. Department of Medicine, Columbia University, New York, NY, USA

    Jacqueline R. Wyatt & C. A. Stein

  2. Isis Pharmaceuticals, Carlsbad, CA, USA

    Jacqueline R. Wyatt & C. A. Stein

Authors
  1. Jacqueline R. Wyatt
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  2. C. A. Stein
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Editor information

Editors and Affiliations

  1. Cardiology Division, Columbia University College of Physicians and Surgeons, New York, NY, USA

    LeRoy E. Rabbani M.D. (Assistant Professor of Medicine) (Assistant Professor of Medicine)

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Wyatt, J.R., Stein, C.A. (1999). Oligonucleotides Containing the G-Quartet Sequence Motif. In: Rabbani, L.E. (eds) Applications of Antisense Therapies to Restenosis. Perspectives in Antisense Science, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5183-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-5183-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7361-2

  • Online ISBN: 978-1-4615-5183-6

  • eBook Packages: Springer Book Archive

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