Critical Considerations and Future Directions

  • Martin R Bennett
  • Stephen M Schwartz
Part of the Perspectives in Antisense Science book series (DARE, volume 3)

Abstract

The upsurge in interest in the use of antisense agents to inhibit restenosis reflects the poor results of clinical trials of conventional agents to affect the restenosis rates. At present, over 12 oligonucleotides are in clinical trials, for a variety of diseases. To examine whether this interest in antisense agents for restenosis is warranted, it is first necessary to analyse the advantages of antisense agents over conventional therapies, and to consider shortfalls in our knowledge of both the disease process, and the use of antisense agents in vivo, both of which wil limit the applicability of this technology to human disease.

Keywords

Toxicity Influenza Oligomer Interferon Thrombin 

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Martin R Bennett
    • 1
  • Stephen M Schwartz
    • 2
  1. 1.Department of MedicineAddenbrooke’s HospitalCambridgeUK
  2. 2.Department of PathologyUniversity of WashingtonSeattleUSA

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