Increased Plasma Membrane Ion-Leakage: A New Hypothesis for Chest Pain and Normal Coronary Arteriograms
Approximately 10–15% of all patients in the US who are subjected to coronary angiography because of anginal chest pain do not show any obvious coronary artery disease. Approximately 15% of these patients have 201-thallium myocardial perfusion defects [1,2]. Despite the normal coronary angiogram most physicians still consider the patients symptoms being due to insufficient myocardial blood perfusion. This is not surprising given the fact that symptoms in this syndrome clearly suggest the presence of myocardial ischemia. Among these are: angina pectoris like chest pains, transient ECG changes suggestive of myocardial ischemia, and myocardial perfusion defects as assessed by 201-thallium scintigraphy. Interestingly, a sizeable proportion of patients with chest pain and normal coronary arteriograms have unexplained fatigue.
KeywordsFatigue Hydrolysis Ischemia Lactate Adenosine
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