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Signal Transduction Through the Growth Hormone Receptor

  • Peter E. Lobie
Part of the Endocrine Updates book series (ENDO, volume 4)

Abstract

The importance of the cloned growth hormone (GH) receptor in the regulation of postnatal somatic growth is evidenced by the demonstration of point mutations and deletions in the gene encoding the GH receptor in Laron type dwarfism (1,2) and sex linked dwarfism in the chicken (3,4). Further, GH receptor gene deletion in mice results in a growth retarded phenotype (5). The mechanism by which the GH receptor mediates the general pleiotropic and specific somatic responses to its ligand have only recently begun to be understood. This review provides a brief discourse on the signal transduction pathways which have been demonstrated to be utilized by GH. The identification of such pathways, at least, provides a basis for understanding the pleiotropic actions of GH.

Keywords

Growth Hormone Focal Adhesion Kinase Tyrosine Phosphorylation Growth Hormone Receptor Growth Hormone Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Peter E. Lobie
    • 1
  1. 1.Institute of Molecular and Cell Biology and Defence Medical Research InstituteNational University of SingaporeSingaporeRepublic of Singapore

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