Growth Hormone pp 253-260 | Cite as

GH Effects on Cardiac Function

  • Jörgen Isgaard
Part of the Endocrine Updates book series (ENDO, volume 4)


Although traditionally associated with regulation of somatic growth, body composition and metabolism, it has become increasingly evident that the GH/IGF-I axis is important for cardiac growth and function. Early observations in acromegalic patients included manifestations such as cardiomegaly. impaired cardiac performance and higher morbidity and mortality in cardiovascular diseases [1,2]. These findings together with more recent data of compromised cardiac function in adult patients with GH deficiency [3–5] have focused the attention to GH as a potentially important regulator of the cardiovascular system. Moreover, a recent study showing beneficial effects of GH treatment of patients with dilated cardiomyopathy has also led to the suggestion of GH as a possible future agent in the treatment of congestive heart failure [6].


Growth Hormone Dilate Cardiomyopathy Cardiac Growth Systolic Wall Stress Growth Hormone Receptor Expression 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Jörgen Isgaard
    • 1
  1. 1.Research Center for Endocrinology and Metabolism, Department of Internal MedicineSahlgrenska University HospitalGöteborgSweden

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