GH Effects on Cardiac Function
Although traditionally associated with regulation of somatic growth, body composition and metabolism, it has become increasingly evident that the GH/IGF-I axis is important for cardiac growth and function. Early observations in acromegalic patients included manifestations such as cardiomegaly. impaired cardiac performance and higher morbidity and mortality in cardiovascular diseases [1,2]. These findings together with more recent data of compromised cardiac function in adult patients with GH deficiency [3–5] have focused the attention to GH as a potentially important regulator of the cardiovascular system. Moreover, a recent study showing beneficial effects of GH treatment of patients with dilated cardiomyopathy has also led to the suggestion of GH as a possible future agent in the treatment of congestive heart failure .
KeywordsGrowth Hormone Dilate Cardiomyopathy Cardiac Growth Systolic Wall Stress Growth Hormone Receptor Expression
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