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Osteoporosis: Genetics, Prevention and Treatment pp 247–274Cite as

Cancer and Bone Disease

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Part of the book series: Endocrine Updates ((ENDO,volume 3))

Abstract

Skeletal metastases cause extensive morbidity in half of all cancer patients (Coleman 87, 1). Thirty to 40% of patients who have bone metastases suffer from painful pathologic fractures that limit their independence during the period preceding death. In addition, 10–40% of cancer patients without skeletal lesions develop the humoral hypercalcemia of malignancy (HHM) (2, 3). Thus, the morbidity associated with the skeletal complications of malignancy is a frequent cause of pain and suffering, an antecedent to repeated hospitalization, and a contributor to increased health care costs. Our goal, as physicians and scientists, is to advance the understanding of skeletal pathophysiology in patients with malignancy so that metastases to bone are prevented, pain is reduced, and patient independence is maintained for as long as possible.

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Authors
  1. Mark S. Nanes M.D., Ph.D.
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  2. Louisa Titus Ph.D.
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Editor information

Editors and Affiliations

  1. Cedars-Sinai Medical Center, Los Angeles, California, USA

    John S. Adams M.D.

  2. University of Kansas Medical School, Kansas City, Missouri, USA

    Barbara P. Lukert M.D.

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© 1999 Springer Science+Business Media New York

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Nanes, M.S., Titus, L. (1999). Cancer and Bone Disease. In: Adams, J.S., Lukert, B.P. (eds) Osteoporosis: Genetics, Prevention and Treatment. Endocrine Updates, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5115-7_15

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  • DOI: https://doi.org/10.1007/978-1-4615-5115-7_15

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