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Sterol Esterification and Homeostasis in a Model Eukaryote

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Intracellular Cholesterol Trafficking

Abstract

The intracellular esterification of sterols by all eukaryotes represents a critical homeostatic response to excess sterol. This process is mediated by a multigene family in several organisms, including the unicellular eukaryote, Saccharomyces cerevisiae (yeast). We describe here our recent efforts to identify molecular components of sterol esterification and sterol transport in this model system. This includes homologs to the acyl-CoA cholesterol acyl transferase (ACAT) gene, a putative homolog to the Niemann Pick C (NPC) gene, and novel yeast genes with human counterparts.

All authors contributed equally to this paper.

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Authors and Affiliations

  1. Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, 630 W168th St., New York, NY, 10032, USA

    Peter Oelkers, Stephen L. Sturley & Arthur Tinkelenberg

  2. Departments of Pediatrics; Physiology and Molecular Biophysics, Columbia University College of Physicians and Surgeons, 630 W168th St., New York, NY, 10032, USA

    Stephen L. Sturley

Authors
  1. Peter Oelkers
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  2. Stephen L. Sturley
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  3. Arthur Tinkelenberg
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Corresponding author

Correspondence to Stephen L. Sturley .

Editor information

Editors and Affiliations

  1. Dartmouth Medical School, USA

    T. Y. Chang

  2. University of Oklahoma Health Sciences Center, USA

    Dale A. Freeman

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Oelkers, P., Sturley, S.L., Tinkelenberg, A. (1998). Sterol Esterification and Homeostasis in a Model Eukaryote. In: Chang, T.Y., Freeman, D.A. (eds) Intracellular Cholesterol Trafficking. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5113-3_4

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  • DOI: https://doi.org/10.1007/978-1-4615-5113-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7326-1

  • Online ISBN: 978-1-4615-5113-3

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