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Intracellular Cholesterol Trafficking pp 273–288Cite as

Selective Uptake of Lipoprotein Free Cholesterol and Its Intracellular Transport — Role of Caveolin

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Abstract

Free cholesterol (FC) from low density lipoprotein (LDL) enters peripheral cells via a N-ethylmaleimide-dependent selective uptake pathway. This pathway regulates cholesterogenesis. and promotes FC efflux via its effect on the transcriptional regulation of caveolin, the major structural protein of caveolae. Caveolae are the terminus at the cell surface of both newly synthesized FC and FC recycled from LDL. Caveolar FC is effectively transferred to extracellular high density lipoprotein (HDL). The activity of this new pathway may explain several paradoxes in current models of the regulation of intracellular FC transport.

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Author information

Authors and Affiliations

  1. Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, California, 94143, USA

    Christopher J. Fielding

  2. Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California, 94143, USA

    Phoebe E. Fielding

Authors
  1. Christopher J. Fielding
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  2. Anita Bist
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  3. Phoebe E. Fielding
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Editor information

Editors and Affiliations

  1. Dartmouth Medical School, USA

    T. Y. Chang

  2. University of Oklahoma Health Sciences Center, USA

    Dale A. Freeman

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© 1998 Springer Science+Business Media New York

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Fielding, C.J., Bist, A., Fielding, P.E. (1998). Selective Uptake of Lipoprotein Free Cholesterol and Its Intracellular Transport — Role of Caveolin. In: Chang, T.Y., Freeman, D.A. (eds) Intracellular Cholesterol Trafficking. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5113-3_17

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  • DOI: https://doi.org/10.1007/978-1-4615-5113-3_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7326-1

  • Online ISBN: 978-1-4615-5113-3

  • eBook Packages: Springer Book Archive

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