The role of oxidative stress in diseases caused by mineral dusts and fibres: Current status and future of prophylaxis and treatment

  • M. Gulumian
Part of the Molecular and Cellular Biochemistry book series (DMCB, volume 32)


Inhalation of silica and asbestos fibres by humans can lead to fibrosis of the lung and cancer. Different mechanistic approaches, including oxidative stress, are used for prophylactic and therapeutic interventions to attenuate the fibrogenic and carcinogenic effects of these particles. Thus far, most of these therapeutic interventions have been only partly successful. A review of the mechanisms which are thought to be involved in mineral particle-induced toxicity and the relevant therapeutic interventions used to date to counteract these mechanisms, will help formulate better prophylactic and treatment intervention strategies in the future. ((Mol Cell Biochem 196: 69-77, 1999)

Key words

mineral particles silica asbestos fibres inflammation fibros 


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Copyright information

© Springer Science+Business Media Dordrecht 1999

Authors and Affiliations

  • M. Gulumian
    • 1
    • 2
  1. 1.National Centre for Occupational Health and Department of Medical BiochemistryJohannesburgSouth Africa
  2. 2.National Centre for Occupational Health and Department of Medical BiochemistryUniversity of the WitwatersrandJohannesburgSouth Africa

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