Myocardial preconditioning: Basic concepts and potential mechanisms

  • Shinji Okubo
  • Lei Xi
  • Nelson L. Bernardo
  • Kazu-ichi Yoshida
  • Rakesh C. Kukreja
Part of the Molecular and Cellular Biochemistry book series (DMCB, volume 32)


Preconditioning is a phenomenon, where brief periods of stress such as ischemia, heat shock or certain pharmacological agents make the heart tolerant to subsequent lethal ischemic injury. Preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel and expression of a number of protective proteins. In this review, the potential role of these mechanisms is discussed. (Mol Cell Biochem 196: 3-12, 1999)

Key words

ischemia preconditioning adenosine protein kinase C KATP channel free radicals heat shock proteins antioxidants nitric oxide 


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Copyright information

© Springer Science+Business Media Dordrecht 1999

Authors and Affiliations

  • Shinji Okubo
    • 1
  • Lei Xi
    • 1
  • Nelson L. Bernardo
    • 1
  • Kazu-ichi Yoshida
    • 1
  • Rakesh C. Kukreja
    • 1
  1. 1.Eric Lipman Laboratories of Molecular and Cellular Cardiology, Division of Cardiology, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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