Abstract
Platelets circulate in the blood stream as anucleate discoid cells, at a number of 150,000–350,000 per μl and have a life span of 10 days in man. They are involved in the early phase of the hemostatic process. When a blood vessel is damaged, platelets are exposed to subendothelial collagen. Together with von Willebrand factor (vWF) an activation process is started in which the platelets immediately adhere to the exposed collagen fibrils, change their shape from discs to spheres with long pseudopods and empty their granule contents (degranulation). Few seconds later more platelets are deposited on the collagen fibrils and the platelets are now also sticking to each other (platelet aggregation). A growing platelet plug is formed in the lesion of the vessel wall as more platelets aggregate.
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References
Abdel-Latif AA. “Metabolism of phosphoinositides.” In: Handbook of Neurochemistry. Ed: A Lajtha. Plenum Publ Corp. (New York) pp 91–131, 1983.
Abrams C, Shattil, SJ. Immunological detection of activated platelets in clinical disorders. Thromb Haemost 65: 467–473, 1991.
Abrams CS, Wu H, Zhao W, Belmonte E, White D, Brass L. Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein coupled and growth factor receptors-a role for pleckstrin PH domains. J Biol Chem 270: 14485–14492, 1995a
Abrams CS, Zhao W, Belmonte E, Brass LF. Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain. J Biol Chem 270: 23317–23321, 1995b.
Abrams CS, Zhang W, Downes CP, Tang X-W, Zhao W, Rttienhouse S. Phospho-pleckstrin inhibits Gβγ-activatible platelet phosphatidylinositol (4,5) bisphosphate-3-kinase. J Biol Chem 271: 25192–25197, 1996.
Aderem A. Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin. Trends Biochem Sci 17: 438–443, 1992.
Aken ML, Ginsberg MH, Plow EF. Mechanisms for expression of thrombospondin on the platelet cell surface. Semin Thromb Haemost 13: 307–316, 1987.
Akkerman JWN, Holmsen H, Loughnane M. Simultaneous measurement of aggregation, secretion, oxygen uptake, proton production, and intracellular metabolites in the same platelet suspension. Anal Biochem 97: 387–393, 1979.
Akkerman JWN, Holmsen H. Interrelationships among platelet responses: studies on the burst in proton liberation, lactate production and oxygen uptake during platelet aggregation and Ca2+ secretion. Blood 57: 956–966, 1981.
Akkerman JWN, Verhoeven AJM. “Energy metabolism and fonction.” In: Platelet responses and metabolism, Vol III. Ed: H Holmsen. CRC Press (Boca Raton, FL), pp 69–99, 1987.
Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEB J 4: 2868–2880, 1990.
Amatruda TTI, Steele DA, Slepak VZ, Simon MI. Gαl6 a G protein α subunit specially expressed in hematopoietic cells. Proc Natl Acad Sci USA 88: 5587–5593, 1991.
Anderson NG, Maller JL, Tonks NK, Sturgill TW. Requirements for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 343: 651–653, 1990.
Ando B, Wiedmer T, Hamilton KK, Sims PJ. Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand Factor to newly expressed cell surface GPIIb-IIIa. J Biol Chem 263: 11907–11914, 1988.
Armstrong RA, Jones RL, Wilson NH. Ligand binding to thromboxane receptors on human platelets: correlation with biological activity. Br J Pharmacol 79: 953–964, 1983.
Auethavekiat V, Abrams CS, Majerus PW. Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I. J Biol Chem 272: 1786–1790, 1997.
Baldassare JJ, Henderson PA, Burns D, Loomis C, Fisher GJ. Translocation of protein kinase C isoenzymes in thrombin-samulated human platelets. Correlation with 1,2-diacylglycerol levels. J Biol Chem 267, 15585–15590, 1992.
Banno Y, Yada Y, Nozawa Y. Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets. J Biol Chem 263:11459–11465, 1988.
Banno Y, Yu A, Nakasmma T, Homma Y, Takenava T, Nozawa Y. Purification and characterization of acytosolic phosphoinositide-phospholipase C (γ2-type) from human platelets. Biochem Biophys Res Commun 167: 396–401, 1990.
Banno Y, Nakashima T, Kumada T, Ebisawa K, Nonomura Y, Nozawa Y. Effects of gelsolin on human platelet cytosolic phosphoinositide-phospholipase C isozymes. J Biol Chem 267: 6488–6494, 1992.
Banno Y, Nakashima T, Hashiya T, Nozawa Y. Endogenous cleavage of phospholipase C-β3 by agonist-induced activation of calpain in human platelets. J Biol Chem 270: 4318–4324, 1995.
Baumgartner HR, Tscopp TB, Meyer D. Shear rate dependent inhibition of platelet adhesion and aggregation on collagenous surfaces by antibodies to Factor VIII/von Willebrand factor. Br J Haematol 44: 127–139, 1980.
Bencxe-Marti K, Lapetina EG. Epinephrine suppresses rap 1B. GAP-activated GTPase activity in human platelets. Proc Natl Acad Sci USA 89: 2784–2788, 1992.
Berman CL, Ybo EL, Wencel-Drake JD, Furie BC, Ginsberg MH, Furie B. A platelet alphagranule membrane protein that is associated with the plasma membrane after activation: characterization and subcellular localization of platelet activation-dependent graule-external membrane protein. J Clin Invest 78: 130–137, 1986.
Berridgde MJ. Calcium oscillations. J Biol Chem 265: 9583–9586, 1990.
Berrigde MJ. Inositol trisphosphate and calcium signalling. Nature 361, 315–317, 1993.
Bevers EM, Comfurius P, Zwaal RFA. Changes in membrane phospholipid distribution during platelet activation. Biochim Biophys Acta 736: 57–66, 1983.
Bevilacqua M, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, Harlan J, Kishimoto K, Lasky L, Mcever R. Selectins: a family of adhesion receptors. Cell 67: 233, 1991.
Bevilacqua MP, Nelson RM. Selectin. J Clin Invest 91: 379–387, 1993.
Bhullar RP, Chardin P, Haslam RJ. Identification of multiple ral gene products in human platelets that account for some but not all of the platelet Ga proteins. FEBS Lett 260: 48–52, 1990.
Bischoff FP, Ponstingl H. Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc Natl Acad Sci USA 88: 10831–10834, 1991.
Blaas P, Berger B, Weber S, Peter HH, Hänsch GM. Paroxysmal nocturnal hemoglobinuria. Enhanced stimulation of platelets by the terminal complement components is related to the lack of C8bp in the membrane. J Immunol 140: 3045–3051, 1988.
Blake RA, Schieven GL, Watson SP. Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets. FEBS Lett 353: 212–216, 1994.
Blockmans D, Deckmyn H, Vermylen J. Platelet activation. Blood Rev 9: 143–156, 1995.
Boguski MS, Mccormick F. Proteins regulating Ras and its relatives. Nature 366: 643–654, 1993.
Bokoch GM, Der CJ. Emerging concepts in the ras superfamily of GTP-binding proteins. FASEB J7: 750–759, 1993.
Bonne C, Martin B, Watada M, Regnault F. The antagonism of prostaglandins I2, E1 and D2 by prostaglandin E2 in human platelets. Thromb Res 21: 13–22, 1981.
Bootman MD, Berridgde MJ. The elemental principles of calcium signalling. Cell 83: 675–678, 1995.
Borsch-Haubold AG, Kramer RM, Watson SP. Cytosolic phospholipase A2 is phosphorylated in collagen-and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase. J Biol Chem 270: 25885–25892, 1995.
Bowen R, Haslam RJ. Effects of nitrovasodilators on platelet cyclic nucleotide levels in rabbit blood: role for cyclic AMP in synergistic inhibition of platelet function by SIN-1 and prostaglandin El. J Cardiovasc Pharmacol 17: 424–433, 1991.
Brass LF, Laposata M, Banga HS, Rittenhouse SE. Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by pertussis toxin-sensitive guanine nucleotide-binding protein: Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, G1. J Biol Chem 261: 16838–16847, 1986.
Brass LF, Hoxie JA, Manning DR. Signalling through G proteins and G protein-coupled receptors during platelet activation. Thromb Haemost 70: 217–223, 1993.
Brass LF. “Molecular basis for platelet activation.” In: Hematology: basic principles and practice. 2nd ed. Ed: R. Hoffman. Churchill Livingstone (New York), pp 1536–1552, 1995.
Brass LF, Manning DR, Cishowski K, Abrams CS. Signalling through G proteins in platelets: to the integrals and beyond. Thromb Haemost 78 581–589, 1997.
Burch RM, Mais DE, Saussy DL Jr, Halushka PV. Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding site from human platelets. Proc Natl Acad Sci USA 82: 7434–7438, 1985.
Bustelo XR, Ledbetier JA, Barbacid M. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature 356: 68–71, 1992.
Butt E, Walter U. Platelets: a practical approach. Eds: Watson SP & Authi KS. IRL Press (Oxford, UK), 1996.
Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U. CAMP-and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. J Biol Chem 269: 14509–14517, 1994.
Capitanio AM, Niewiarowski S, Rucinski B, Tuszynski GP, Cierniewski CS, Hershock D, Kornecki E. Interaction of platelet factor 4 with human platelets. Biochim Biophys Acta 839: 161–173, 1985.
Carlson KE, Brass LF, Manning DR. Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than Gi in human platelets. J Biol Chem 264: 13298–13305, 1989.
Carty DJ, Padrell E, Codina J, Birnbaumer L, Hildenbrandt JD, Iyengar RJ. Distinct guanine nucleotide binding and release properties of the three Gi proteins. J Biol Chem 265: 6268–6273, 1990.
Casey PJ. Lipid modifications of G proteins. Curr Opinion in Cell Biol 6: 219–225, 1994.
Casey PJ. Protein lipidation in cell signalling. Science 268: 221–225, 1995.
Castle AG, Crawford N. Platelet microtubule subunit proteins. Thromb Haemostas 42: 1630–1633, 1979.
Cavallini L, Coassin M, Borean A, Alexandre A. J Biol Chem 271: 5541–5551, 1996.
Chang N-S, Leu RW, Rummage JA, Anderson JK, Mole JE. Regulation of complement functional efficiency by histidine-rich glycoprotein. Blood 79: 2973–2980, 1992.
Chao W, Olson MS. Platelet-activating factor: receptors and signal transduction. Biochem J 292: 617–629, 1993.
Chardin P, Boquet P, Madaule P, Popoff MR, Rubin EJ, Gill DM. The mammalian G protein rhoC is ADP ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J 8: 1087–1092, 1988.
Chen JW, Murphy TL, Willingham MC, Pastan I, August JT. Identification of two lysosomal membrane glycoproteins. J Cell Biol 101: 85–95, 1985.
Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79: 507–513, 1994.
Cichowski K, McCormick F, Brugge JS. p21DGAP association with Fyn, Lyn and Yes in thrombinactivated platelets. J Biol Chem 267: 5025–5028, 1992.
Cichowski K, Brugge JS, Brass LF. Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets. J Biol Chem 271: 7544–7550, 1996.
Clapham DE, Neer EJ. New roles for G-protein βγ-dimers in transmembrane signalling. Nature 365: 403–406, 1993.
Clark EA, Shatttil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin αIbβ3. J Biol Chem 269: 28859–28864, 1994a.
Clark EA, Brugge JS. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci 19: 464–469, 1994b.
Clark EA, Brugge JS. Integrins and signaltransduction pathways: the road taken. Science 268: 233–239, 1995.
Cobb MH, Goldsmith EJ. How MAP kinases are regulated. J Biol Chem 270: 14843–14846, 1995.
Cockcroft S, Thomas GMH: Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors. Biochem J. 288: 1–9, 1992.
Cohen GB, Ren R, Baltimore D. Modular Binding Domains in Signal Transduction Proteins. Cell 80: 237–248, 1995.
Cohen I, Gerrard JM, White JG. Ultrastructure of clots during isometric contraction. J Cell Biol 93: 775–787, 1982.
Coller BS. Platelets and thrombolytic therapy. N Engl J Med 322: 33–42, 1990.
Conti MA, Adelstein RS. Phosphorylation by cyclic adenosine 3’,5’-monophosphate-dependent protein kinase regulates myosin light chain kinase. Fed Proc 39: 1569–1573 1980.
Cooper B, Ahern D. Characterization of the platelet PGD2 receptor. Loss of PGD2 receptors in platelets with myeloproliferative disorders. J Clin Invest 64: 586–590, 1979.
Coppola J, Bryant S, Roda T, Conway D, Barbacid M. Mechanism of action of the vav protooncogene, Cell Growth Diffl 2: 95–105, 1991.
Cox AD, Goodall AH. “Activation-specific neo-antigen on platelet detected by monoclonal antibodies.” In: Current Studies in Haematology and Blood Transfusion, Vol 58. Eds: Albertini A, Lenfant CL, Mannucci PM, Sixma JJ. (Karger, Basel), pp 194–199, 1991.
Crespo P, Xu N, Simonds WF, Gutxind JS. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369: 418–420, 1994.
Crespo P, Bustelo XR, Aaronson DS. Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene 13: 455–460, 1996.
Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385: 169–172, 1997.
Cross MJ. Effect of fibrinogen on the aggregation of platelets by adenosine diphosphate. Thrombs Diath Haemorrh 12: 521, 1964.
Dachary-Prigent J, Totif Satta N, Pasquet JM, Uzan A, Freyssinet JM. Physiopathological significance of catalytic phospholipids in the generation of thrombin. Semin Thromb Hemostas 22: 157–164, 1996.
Daniel JL, Mulish IR, Holmsen H. Myosin phosphorylation in intact platelets. J Biol Chem 256: 7510–7514, 1981.
Daniel JL, Molish IR, Rigmaiden M, Steward G. Evidence for a role of myosin phosphorylation in the initiation of the platelet shape change response. J Biol Chem 259: 9826–9831, 1984.
Daniel JL, Dangelmaier C, Jin J, Ashby B, Smith JB, Kunapuli SP. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 273: 2024–2029, 1998.
De-Caterina M, Strazzullo P, Iacone R, Pompeo F, Varriale V, Grimaldi E, Scopacasa F. Determination of the kinetics of Na+/H+ exchange in platelets using the Coulter S-plus cell counter. Eur J Clin Biochem 32: 57–60, 1994.
De Chaffoy De Courcelles D, Roevens P, Belle H. Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets. FEBS Lett 195: 115–118, 1986.
De Chaffoy De Courcelles D, Roevens P, Belle H. Prostaglandin E1 and forskolin antagonize C-kinase activation in the human platelet. Biochem J 244: 93–99, 1987.
Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A. Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity 5: 591–604, 1996.
De Marco L, Mazzucato M, Masotti A, Fenton JW, Ruggeri ZM. Function of glycoprotein Ibα in platelet activation induced by α-thrombin. J Biol Chem 266: 23776–23783, 1991.
Derenleau DA, Luthy R, Luscher EF. Stochastic response of human platelets to stimulation of shape changes and secretion. Proc Natl Acad Sci USA 83: 2076–2080, 1986.
Derenleau DA. Blood platelet shape change ABCs. Trends Biochem Sci 12: 439–442, 1987.
Detwiler TC, Feinman RD. Kinetics of the thrombin-induced release of calcium (II) by platelets. Biochemistry 12: 282–289, 1973.
Devine DV, Rosse WF. Regulation of the activity of platelet-bound C3 convertase of the alternative pathway of complement by factor H. Proc Natl Acad Sci USA 84: 5873–5877, 1987.
DeVivo M, Iyengar R. G protein pathways: signal processing by effectors. Mol Cell Endocrinol 100: 65–70, 1994.
Dhar A, Shukla SD. Tyrosine kinases in platelet signalling. Br J Haematol 84: 1–7, 1993.
Dickeson SK, Walsh JJ, Santoro SA. Contributions of the I and EF hand domains to the divalent cationdependent collagen binding activity of the alpha2betal integrin. J Biol Chem 272: 7661–7668, 1997.
Dikic I, Tokiwa G, Lev S, Courtnedge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383: 547–550, 1996.
Downes CP, Carter AN. Phosphoinositide 3-kinase — A new effector in signal transduction. Cell Signal 3: 501–513, 1991.
Downward J. The ras superfamily of small GTP-binding proteins. Trends Biochem Sci 15: 469–472, 1990.
Downward J. “Role of phosphoinostide-3-OH kinase in ras signaling.” In: Signal Transduction in Health and Disease, Advances in Second Messenger and Phosphoprotein Research, Vol 31. Eds: J Corbin and S Francis. Lippincott-Raven Publishers (Philadelphia), 1997.
Enouff J, Giraud F, Bredoux R, Bordeau N, Sarkadi B, Levy-Toledano S. Stimulation of the 23-Kd protein cAMP dependent phosphorylation by inositol 1,4,5 trisphosphate in human platelet membrane vesicles. Biochem Biophys Commun 145: 139–145, 1987.
Exton JH. Phosphoinositide phospholipases and G proteins in hormone action. Annu Rev Physiol 56: 349–369, 1994.
Febbraio M, Silverstein RL. Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. J Biol Chem 265: 18531–18537, 1990.
Fisher TH, Gatling MN, Lacal JC, White GC. Rap 1B, a cAMP-dependent protein kinase substrate, associates with the platelet cytoskeleton. J Biol Chem 265: 19405–19408, 1990.
Fitzgerald GA. Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists. Am J Cardiol 68: 11B–15B, 1991.
Fox JEB, Boyles JK, Reynolds CC, Phillips DR. Actin filament content and organization in unstimulated platelets. J Cell Biol 98: 1985–1991, 1984.
Fox JEB. Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib. J Clin Invest 75: 1673–1683, 1985.
Fox JEB, Lipfert L, Clark EA, Reynolds CC, Austin CD, Brugge JS. On the role of the platelet membrane skeleton in mediating signal transduction. J Biol Chem 268: 25973–25984, 1993a
Fox JEB. The platelet cytoskeleton. Thromb Haemost 70: 884–893, 1993b
Fox JEB. Platelet activation: New aspects. Haemostasis 26: 102–131, 1996.
Frangioni JV, Oda A, Smith M, Salzman EW, Neel BG. Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. EMBO J 12. 4843–4856, 1993.
Fredholmi BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev 46: 143–156, 1994.
Frølich KW, Aarbakke GM, Holmsen H. Chlorpromazine increases the turnover of metabolically active phosphoinositides and elevates the steady-state level of phosphatidylinositol-4-phosphate in human platelets. Biochem Pharmacol 44: 2013–2020, 1992.
Fujimoto T, Ohara S, Hawiger J. Thrombin-induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets. J Clin Invest 69: 1212–1222, 1982.
Fukami M, Holmsen H. Diacylglycerol elevations in control platelets are unaccompanied by pleckstrin phosphorylation. Implications for the role of diacylglycerol in platelet activation. Eur J Biochem 228: 579–586, 1995.
Fukuda M, Vntala J, Matteson J, Carlsson SR. Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-Lamp-1 and h-Lamp-2. Comparison of their deduced amino acid sequences. J Biol Chem 263: 18920–18928, 1988.
Gaarder A, Jonsen J, Laland S, Hellem AJ, Owren P. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature 192: 531–532, 1961.
Gagn WA Manning DR Catani L Gerwirtz A Poncz M Brass LF Identification of Gzα as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. Blood 781247–1253 1991
Gartner IX, Ogilvie ML. Peptides and monoclonal antibodies which bind to platelet glycoproteins IIb and/or IIIa inhibit clot retraction. Thromb Res 49: 43–53, 1988.
Gemmel CH, Sefton MV, Yeo EL. Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. J Biol Chem 268: 14586–14589, 1993.
George PY, Helkamp Jr GM. Purification and characterization of a phosphatidylinositol transfer protein from human platelets. Biochim Biophys Acta 836: 176–184, 1985.
Gerhard JM, White JG, Peterson DA. The platelet dense tubular system: its relationship to prostaglandin synthesis and calcium flux. Thromb Haemost. 40: 224–231, 1978.
Gerrard JM, Lint D, Sims PJ, Wiedmer T, Fugate RD, McMillan E, Robertson C, Israels SJ. Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome. Blood 77: 101–112, 1991.
Gibbins J, Asselin J, Farndale R, Barnes M, Law CL, Watson SP. Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets. J Biol Chem 271: 18095–18099, 1996.
Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shatitl SJ. Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem 266: 17261–17268, 1991.
Gilman AG. G proteins: transducers and receptor generated signals. Annu Rev Biochem 56: 615–623, 1987.
Golden A, Nemeth SP, Brugge JS. Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. Proc Natl Acad Sci USA 83: 852–856, 1986.
Goldschmidt-Clermont PJ, Machesky LM, Baldassare JJ, Pollard TP. The actin-binding protein binds PIP2 and inhibits its hydrolysis by phospholipase C. Science 247: 1575–1578, 1990.
Goody RS. Signal transduction: How G proteins turn off. Nature 372: 220–221, 1994.
Grabarek J, Raychowdhury M, Ravid K. Identification and functional characterization of protein kinase C isoenzymes in platelets and HEL cells. J Biol Chem 267: 10011–10020, 1992.
Graber SE, Hawiger J. Evidence that changes in platelet cyclic AMP levels regulate the fibrinogen receptor on human platelets. J Biol Chem 257: 14606–14609, 1982.
Grand RJA, Turnell AS, Grabham PW. Cellular consequences of thrombin-receptor activation. Biochem J 313: 353–368, 1996.
Grant JA, Scrutton MC. Novel alpha2-adrenoreceptors primarily responsible for inducing platelet aggregation. Nature 227: 659–661, 1979.
Grant PG, Decamp DL, Bailey JM, Colman RF, Colman RW. LOW-KM cyclic AMP phosphodiesterase from human platelets. Adv second Messenger Phosphoprotein Res 25: 73–85, 1992.
Grondin P, Plantavid M, Sultan C, Breton M, Mauco G, Chap H. Interaction of pp60c-src, phospholipase C, Inositol-lipid, and diacylglycerol kinases with the cytoskeletons of thrombin-stimulated platelets. J Biol Chem 266: 15705–15709, 1991.
Gryglewski RJ, Botting RM, Vane JR Mediators produced by the endothelial cell. Hypertension 12: 530–548, 1988.
Gryglewski RJ. Interactions between nitric oxide and prostacyclin. Seminars Thromb Heam 19: 158–166, 1993.
Halenda SP, Volpi M, Zavoico GB, Sha’afi RI, Feinstein MB. Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40–41 kDa protein that is ADP ribosylated by pertussis toxin in human platelets. FEBS Lett 204: 341–346, 1986.
Hamberg M, Samuelsson B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc Natl Acad Sci USA 71: 3400–3408, 1974.
Hammacher A, Hellman U, Johnsson A, Ostman A, Gunnarsson K, Westermark B, Wasteson Å, Heldin C-H. A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain. J Biol Chem 263: 16493–16498, 1988.
Hanahan DJ, Demopoulos CA, Lehr J, Pinkard RN. Identification of platelet activating factor isolated from rabbit basophils as glyceryl ether phosphorylcholine. J Biol Chem 255: 5514–5516, 1980.
Hanasaki K, Arita H. Recent aspects of TXA2 action on platelets and blood vessels. Platelets 2: 69–76, 1991.
Hänsch GM, Gemsa D, Resch K. Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and the channel forming antibiotic nystatin: inhibition of the recyclation of liberated arachidonic acid. J Immunol 135: 1320–1324, 1986.
Hänsch GM. The homologous species restriction of the complement attack: structure and function of the C8 binding protein. Curr Top Microbiol Immunol 140: 109–118, 1988.
Harlan JE, Hajduk PJ, Yoon HS, Fesik SW. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371: 168–170, 1994.
Harmon JT, Jamieson GA. Activation of platelets by alpha-thrombin is a receptor-mediated event. J Biol Chem 261, 15928–15933, 1986.
Harris HE, Weeds A. Platelet actin: subcellular distribution and association with profilin. FEBS Lett 90: 84–88, 1978.
Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82: 643–653, 1995.
Hartwig JH, Barkalow K. Polyphosphoinositide synthesis and platelet shape change. Curr Opinion Hematology 4: 351–356, 1997.
Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 354: 311–314, 1991.
Hart MJ, Eva A, Zangrilli D, Aaronson SA, Evans T, Cerione RA, Zheng Y. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem 269: 62–65, 1994.
Haslam RJ, Lynham JA, Fox JEB. Effects of collagen, ionophore A23187 and prostaglandin E1 on the phosphorylation of specific proteins in blood platelets. Biochem J 178: 397–406, 1979.
Haslam RJ, Salama SE, Fox JEB, Lynham JA, Davidson MML. Platelets: Cellular response mechanisms and their biological significance, J. Wiley & Sons (NY), 1980.
Haslam RJ, Kolde BJ, Hemmings BA. Pleckstrin domain homology. Nature 363: 309–310, 1993.
Hattori R, Hamilton KK, Mcever RP, Sims PJ. Complement proteins C5-9 induce secretion of high molecular weight multimers of endothelial von Willebrand Factor and translocation of granule membrane protein GMP-140 to the cell surface. J Biol Chem 264: 9053–9060, 1989.
Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ. Distinct pathways of Gi and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem 270: 17148–17153, 1995.
Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ. Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signalling pathway. J Biol Chem 271: 12133–12136, 1996.
Heemskerk JWM, Sage SO. Calcium signalling in platelets and other cells. Platelets 5: 295–316, 1994.
Henn V, Slupsky Jr, Gräfe M, Anagnostopoulos I, Förster R, Müller-Berghaus G, Kroczek RA. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391: 591–594, 1998.
Hoffman M, Monroe DM, Roberts HR. Coagulation factor IXa binding to activated platelets and plateletderived microparticles: a flow cytometric study. Thromb Haemost 68: 74–78, 1992.
Holme R, Sixma JJ, Murer EH, Hovig T. Demonstration of platelet fibrinogen secretion via the surface connecting system. Thromb Res 3: 347–356, 1973.
Holme R, Sdcma JJ, Murer EH, Hovig T. Errata: Demonstration of platelet fibrinogen secretion via the surface connecting system. Thromb Res 4: 377–382, 1974.
Holmsen H, Day HJ. The selectivity of the thrombin-induced platelet release reaction: subcellular localization of released and retained constituents. J Clin Med 75: 840–855, 1970.
Holmsen H, Setkowsky CA, Day HJ. Effects of antimycin and 2-deoxyglucose on adenine nucleotides in human platelets. Role of metabolic adenosine triphosphate in primary aggregation, secondary aggregation and shape change in platelets. Biochem J 144: 385–396, 1974.
Holmsen H. Classification and possible mechanisms of action of drugs that inhibit platelet aggregation. Ser Haematol 8: 50–80, 1976.
Holmsen H, Weiss HJ. Secretable storage pools in platelets. Annu Rev Med 30: 119–134, 1979.
Holmsen H, Kaplan KL, Dangelmaier CA. Differential energy requirements for platelet responses: a simultaneous study of aggregation, three secretory processes, arachidonate liberation, phosphatidylinositol breakdown and phosphatidate production. Biochem J 208: 9–18, 1982.
Holmsen H. “Cyclic AMP-dependent protein kinases and protein kinase C.” In: Platelet responses and Metabolism. Response-Metabolism Relationships, Vol III Ed: H Holmsen. CRC Press (Boca Raton, FL), pp 51–68, 1987.
Holmsen H, Tysnes OB, Verhoeven AJM. “Polyphosphoinositide metabolism in resting and stimulated platelets.” In: The platelet amine storage granule Eds. KM Meyers and CD Barnes. CRC Press (Boca Raton), pp 97–116, 1992.
Horak ID, Corcoran ML, Thompson PA, Wahl LM, Bolen JB. Expression of p60fyn in human platelets. Oncogene 5: 597–602, 1990.
Hordijk PL, Verlaan I, van Corven EJ, Moolenaar WH. Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat-1 fibroblasts. Evidence that phosphorylation of MAP kinase is mediated by the Gip21Irs-pathway. J Biol Chem 269: 645–651, 1994.
Horne WC, Norman NE, Schwartz DB, Simons ER. Changes in cytoplasmic pH and membrane potential in thrombin-stimulated human platelets. Eur J Biochem 120: 295–302, 1981.
Houle JJ, Leddy JP, Rosenfeld SI. Secretion of the terminal complement proteins, C5-C9, by human platelets. Clin Immunol Immunopathol 50: 385–393, 1989.
Houston DS, Shepherd JT, Vanhouette PM. Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries: role of serotonin, thromboxane A2 and adenine nucleotides. J Clin Invest 78: 539–544, 1986.
Hsu-Lin S, Berman CL, Furie BC, August D, Furie B. A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets. J Biol Chem 259: 9121–9126, 1984.
Huang M-M, Bolen JB, Barnwell JW, Shattil SH, Brugge JS. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn and Yes protein tyrosine kinases in human platelets. Proc Natl Acad Sci USA 88: 7844–7848, 1991.
Huang M-M, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SH. Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK J Cell Biol. 122: 473–483, 1993.
Hung SC, Ghali NI, Venton DL, LE Breton GC. Specific binding of the thromboxane A2 antagonist 13-azaprostanoic acid to human platelet membranes. Biochem Biophys Acta 728: 171–178, 1983.
Hotteman E, Ukena D, Lenschow V, Schwabe U. Adenosine receptors in human platelets. Naunyn Schmieedebergs Arch Pharmacol 325: 226–233, 1984.
Imai A, Hattori H, Takahashi M, Nozawa Y. Evidence that cyclic AMP may regulate Ca2+-mobilization and phospholipases in thrombin-stimulated human platelets. Biochem Biophys Res Commun 112: 693–700; 1983.
Inaba K, Umeda Y, Yamana Y, Urakami M, Nada M. Characterization of human platelet vasopressininduced platelet aggregation and vasopressin binding to platelets. Clin Endocrinol 29: 377–386, 1988.
Inagaki M, Kawamoto S, Hidaka H. Serotonin secretion from human platelets may be modified by Ca2+-activated, phospholipid-dependent myosin phosphorylation. J Biol Chem 259: 14321–14323, 1984.
I~arrea P, Gomez-Cambronero J, Nieto M, Sanchez Crespo M. Characteristics of the binding of platelet-activating factor to platelets of different animal species. Eur J Pharmacol 105: 309–315, 1984.
Inazu T, Taniguchi T, Yanagi S, Yamamura H. Protein-tyrosine phosphorylation and aggregation of intact human platelets by vanadate with H2O2. Biochem Biophys Res Commun 170: 259–263, 1990.
Inglesej Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. Trends Biochem Sci 20: 151–156, 1995.
Ingley E, Hemmings BA. Plecksuin homology (PH) domains in signal transduction. J Cell Biochem 56: 436–443, 1994.
Isenberg WM, Bainton DF. “Megacarocyte and platelet structure.” In: Hematology: basic principles and practice, 2nd ed Ed: R Hoffman, Churchill Livingstone (New York), pp 1516, 1995.
Israels S J, Gerrard JM, Jacques YV, McNicol A, Cham B, Nishbori M, Bainton DF. Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140). Blood 80: 143–152, 1992.
Iwamoto S-I, Kawasaki T, Kambayashi J-I, Ariyoshi H, Monden M. Platelet microparticles: A carrier of platelet-activating factor? Biochem Biophys Res Commun 218: 940–944, 1996.
Janmey PA, Stossel TP. Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature 325: 362–364, 1987.
Janmey PA, Matsudaira PT. Functional comparison of villin and gelsolin. J Biol Chem 263: 16738–16743, 1988.
Jensen BO, Holmsen H. Nitric oxide (NO)-platelet interactions: inhibition is independent of the prostanoid and ADP pathways. Platelets 6: 83–90, 1995.
Jin J, Daniel JL, Kunapuli SP. Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem 273, 2030–2034, 1998.
Johansson JS, Nied LE, Haynes DH. Cyclic AMP stimulates Ca(2+)-ATPase-mediated Ca2+ extrusion from human platelets. Biochim Biophys Ada 1105. 19–28, 1992.
Jones TLZ, Simonds WF, Merendino JJ, Brann MR, Spiegel AM. Myristoylation of an inhibitory GTP-binding protein a subunit is essential for its membrane attachment Proc Natl Acad Sci 87: 568–572, 1990.
Jungi TW, Spücher MO, Nydegger UE, Barandun S. Platelet-leukocyte interaction: selective binding of thrombin-stimulated platelets to human monocytes, polymorphonuclear leukocytes and related cell lines. Blood 647: 629–636, 1986.
Jy W, Horstman L, Wang F, Arce M, Mao WW, Ahn YS. Platelet factor 3 in plasma fractions: Its relation to microparticle size and thrombosis. Thromb Res 80: 471–482, 1995.
Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: Guidelines on nomenclature. FASEB J 6: 2512–1513, 1992.
Kaibuchi K, Tarai Y, Sawamura M. Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem 258: 6701–6709, 1983.
Kane WH, Davie EW. Blood coagulation factor V and VIII: Structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders. Blood 71: 539–555, 1988.
Kanoh H, Banno Y, Hirata M, Nozawa Y. Partial purification and characterization of phosphatidylinositol kinases from human platelets. Biochim Biophys Acta 1046: 120–126, 1990.
Kaplan DR, Chao FC, Stiles CD, Antoniades HN, Scher CD. Platelet alpha granules contain a growth factor for fibroblasts. Blood 53: 1043–1052, 1979.
Kaplan KL, Broekman MJ, Chernoff A, Lesznik GR, Drillings M. Platelet alpha-granule proteins — studies on release and subcellular localization. Blood 53: 604–618, 1979.
Karniguian A, Zahraoui A, Tavitian A. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6 and rab8 proteins. Proc Natl Acad Sci USA 90: 7647–7651, 1993.
Kaziro Y, Itoh H, Kozasa T, Nakafuku M, Satoh T. Structure and function of signal-transducing GTP-binding proteins. Annu Rev Biochem 60: 349–400, 1991.
Keely P-J, Parise L-V. The alpha-2-beta-l integrin is a necessary co-receptor for collagen-induced activation of Syk and the subsequent phosphorylation of phospholipase C-gamma-2 in platelets. J Biol Chem 271: 26668–26676, 1996.
Kenney DM, Davis AE. Association of alternative complement pathway components with human blood platelets: secretion and localization of factor D and B1H globulin. Clin Immunol Immunopathol 21: 351–363, 1981.
Kim D, Lewis DL, Graziadei L. G-protein βγ-subunits activate the cardiac muscarinic K+ channel via phospholipase A2. Nature 337: 557–559, 1989.
Kinoshita T, Medof ME, Silber R, Nussenzweig V. Distribution of decay-accelerating factor in the periheral blood of normal individuals and patients with paroxysmal nocturnal hemoglobinuria. J Exp Med 162: 75–92, 1985.
Kitchens CS, Newcomb TF. Factor XIII. Medicine (Baltimore) 58: 413, 1979.
Kloprogge E, Akkerman JWN. Binding kinetics of PAF-acether (l-O-alkyl-s-acetyl-sn-glycerol-3-phosphocholine) to intact platelets. Biochem J 223: 901–909, 1985.
Kloprogge E, Mommersteg M, Akkerman JWN. Kinetics of platelet-activating factor l-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine-induced fibrinogen binding to human platelets. J Biol Chem 261: 11071–11076, 1986.
Knight DE, Scrutton MC. Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion. Nature 309: 66–68, 1984.
Koch CA, Anderson D, Moran MF, Ellis C, Pawson T. SH2 and SH3 domains. Elements that control interactions of cytoplasmic signalling proteins. Science 252: 668–674, 1991.
Koerner TA, Cunningham MT, Zhang DS. The role of membrane lipid in the platelet storage lesion. Blood Cells 18: 481–497; discussion 498–500, 1992.
Kometani M, Sato T, Fuji T. Platelet cytoskeletal components involved in shape change and secretion. Thromb Res 41: 801–810, 1986.
Kramer RM, Roberts EF, Hyslop PA, Utierback BG, Hui KY, Jakubowski JA. Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. J Biol Chem 270: 14816–14823, 1995.
Kucera GL, Rittenhouse SE. Human platelets form 3-phosphorylated phosphoinositides in response to_α-thrombin, U 46619 or GTPγS. J Biol Chem 265: 5345–5348, 1990.
Lanza F, Beretz A, Stierle A, Hanau D, Kubina M, Cazenave JP. Epinephrine potentates human platelet activation but is not an aggregating agent. Am J Physiol 255: 1276–1288, 1988.
Lapeitna EG, Reep B, Ganong BR, Bell RM. Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets J Biol Chem 260: 1358–1365, 1985.
Lapeitna EG, Reep B, Chang KJ. Treatment of human platelets with trypsin, thrombin or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein. Proc Natl Acad Sci USA 83: 5880–5883, 1986a.
Lapetina EG. Incorporation of synthetic 1,2-diacylglycerol into platelet phosphatidylinositol is increased by cyclic AMP. FEBS Lett 195: 111–114, 1986b.
Lapetina EG, Lacal JC, Reep BR, Molina Y, Vedia L. A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. Proc Natl Acad Sci USA 86: 3131–3134, 1989.
Lassing I, Linderg U. Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. Nature 314: 472–474, 1985.
Lassing I, Linderg U. Evidence that the phosphatidylinositol cycle is linked to cell motility. Exp Cell Res 174: 1–15, 1988.
Lassing I, Linderg U. Polyphosphoinositide synthesis in platelets stimulated with low concentrations of thrombin is enhanced before the activation of phospholipase C. FEBS Lett 262: 231–233, 1990.
Lebowitz EA, Cooke R. Contractile properties of actomyosin from human blood platelets. J Biol Chem 253: 5443–5447, 1978.
Lerea KM, Glomset JA, Krebs EG. Agents that elevate cAMP levels in platelets decrease thrombin binding. J Biol Chem 262: 282–288; 1987.
Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, Schlessinger J. Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions. Nature 376: 739–744, 1995.
Li RY, Gatts F, Ragab A, Ragab-Thomas JMF, Chap H. Translocation of an SH2-containing protein tyrosine phosphatase (SH-PTP1) to the cytoskeleton of thrombin-activated platelets. FEBS Lett 343: 89–93, 1994.
Lin AH, Morton DR, Gorman RR. Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes. J Clin Invest 70: 1058–1065, 1982.
Linder ME, Mddelton P, Hepler JR, Taussig R, Gilman AG, Mumby SM. Lipid modification of G proteins: α subunits are palmitoylated. Proc Natl Acad Sci USA 90: 3675–3679, 1993.
Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAk in platelets. J Cell Biol 119: 905–912, 1992.
Logotheis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 325: 321–326, 1987.
Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 275: 394–397, 1997.
López JA, Dong JF. Structure and function of the glycoprotein Ib-IX-V complex. Curr Opinion Hematol 4: 323–329, 1997.
Lowy DR, Willumsen BM. Function and regulation of ras. Annu rev Biochem 62: 851–891, 1993.
Lutirell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ. Role of c-Src tyrosine kinase in G protein-coupled receptor-and Gβγ subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem 271: 19443–19450, 1996.
Lynch JM, Henson PM. The intracellular retention of newly synthesized platelet-activating factor. J Immunol 137: 2653–2661, 1986.
Macintyre DE, Armstrong RA. “Agonists and receptors: prostaglandins and thromboxanes.” In: Platelet Responses and Metabolism. Receptors and Metabolism, Vol II Ed. H Holmsen, CRC Press (Boca Raton FL), pp 93–103, 1987
Mackenzie AB, Mahaut-Smith MP, Sage SO. Activation of receptor-operated cation channels via P2x1 not P2t purinoceptors in human platelets. J Biol Chem 271: 2879–2881, 1996.
Maclouf J, Fruteau DE, Laclos B, Borgeat P. Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxyeicosatetraenoic acid. Proc Natl Acad Sci USA 79: 6042–6046, 1982.
Maclouf JA, Murphy RC. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets: apotential source for leukotriene C4. J Biol Chem 263: 174–181, 1988.
Madshus IH. Regulation of intracellular pH in eukaryotic cells. Biochem J 250: 1–8, 1988.
Marcus AJ, Broekman MJ, Safier LB, Ullman HL, Islam N, Sherhan CN, Rutherford LE, Korchak HM, Weissmann G. Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem Biophys Res Commun 109: 130–137, 1982.
Marcus AJ, Safer LB, Ullman HL. 12S-20-dihydroxyeicosatetraenoic acid: a new eicosanoid synthesized by neutrophils from 12S-hydroxyeicosatetraenoic acid produced by thrombin-or collagen-stimulated platelets. Proc Natl Acad Sci USA 81: 903–907, 1984.
Marcus AJ, Safer LB, Ullman HL. Platelet neutrophil interaction. J Biol Chem 263: 2223–2229, 1988.
Marcus AJ, Safer LB, Hajjar KA. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase: thromboregulation by endothelial cells. J Clin Invest 88: 1690–1696, 1991.
Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356: 71–74, 1992.
Markwardt F, Hoffman A. Effects of papaverine on cyclic AMP phosphodiesterase in human platelets. Biochem Pharmacol 19: 2519, 1970.
Mason RG, Zucker WH, Shimoda BA, Chuang HY, Kingdon HS, Clark HG. study of the reactions of blood with artificial surfaces. Use of the thrombogenerator. Lab Invest 31: 143–155, 1974.
Matsumoto T, Beach D. Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell 66, 347–360, 1991.
Mauco G, Dangelmaier CA, Smith JB. Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets. Biochem J 244: 933–940, 1984.
Mauco G, Dajeans P, Chap H, Douste-Blazy L. Subcellular localization of inositol lipids in blood platelets as deduced from the use of labeled precursors. Biochem J 244: 757–761, 1987.
Maurice DH, Haslam RJ. Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol 37: 671–681, 1991.
Markwardt F, Hoffman A. Effects of papaverine on cyclic AMP phosphodiesterase in human platelets. Biochem Pharmacol 19: 2519–2520, 1970.
Mayeeb J, Ren R, Clark KL, Baltimore DL. A putative modular domain present in diverse signalling proteins. Cell 73: 629–630, 1993.
McEver RP, Martin MN. A monoclonal antibody to a membrane glycoprotein binds only to activated platelets. J Biol Chem 259: 9799–9804, 1984.
Mckean ML, Smith JB, Silver MJ. Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid. J Biol Chem 156: 1522–1524, 1981.
Mclean JR, Maxwell RE, Hertler D. Fibrinogen and adenosine diphosphate-induced aggregation of platelets. Nature 202: 605–606, 1964.
Mcmanama GP, Johnson PC, Salzman EW. “In vitro platelet responses: adhesion to artificial surfaces.” In: Platelet Responses and Metabolism, Vol I. Ed: H Holmsen. CRC Press (Boca Raton, FL), pp 63–79, 1986.
Menche D, Israel A, Karpatkin K. Platelets and microtubules. Effect of colchicine and D2O on platelet aggregation and release induced by ionophore A23187. J Clin Invest 66: 284–291, 1980.
Meizelaar MJ, Heijnen HF, Sixma JJ, Nieuwenhuis HK. Identification of a 33-Kd protein associated with the alpha-granule membrane (GMP-33) that is expressed on the surface of activated platelets. Blood 79: 372–379, 1992.
Miller OV, Johnson RA, Gorman RR. Inhibition of PGE1-stimulated cyclic AMP accumulation by thromboxane A2. Prostaglandins 13: 599–609, 1977.
Miller OV, Gorman RR. Evidence for distinct prostaglandin I2 and D2 receptors in human platelets. J Pharm Exp Ther 210: 134–140, 1979.
Milligan G, Mullaney I, McCallum JF. Distribution and relative levels of expression of the phosphoinositidase-C-linked G-proteins Gqα and G11α: Absence of G11α in human platelets and haemopoietically derived cell lines. Biochem Biophys Acta Mol Cell Res 1179: 208–212, 1993.
Milligan G, Parenti M, Magee AI. The dynamic role of palmitoylation in signal transduction. Trends Biochem Sci 20: 181–186, 1995.
Mills DCB, Robb IA, Roberts CCK. The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation. J Physiol 195: 715–729, 1968.
Mills DCB, Smith JB. The influence on platelet aggregation of drugs that effect the accumulation of adenosine 3’,5’-cyclic monophosphate in platelets. Biochem J 121: 185–196, 1971.
Mills DCB, Smtih JB. The control of platelet responsiveness by agents that influence cyclic AMP levels. Ann NY Acad Sci 201: 391–399, 1972.
Mills DCB. Changes in the adenylate energy charge in human blood platelets induced by adenosine diphosphate. Nature New Biol 243: 220, 1973.
Mills DCB. “The mechanism of action of antiplatelet drugs.” In: Hemostasis and thrombosis. Eds: RW Colman, J Hirsh, VJ Marder, EW Salzman. JB Lippincott (Philadelphia) pp 1058–1067, 1982.
Miyakawa Y, Oda A, Druker BJ, Ozaki K, Handa M, Ohashi H, Ikeda Y. Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Blood 89: 2789–2798, 1997.
Miyazono K, Takaku F. Platelet-derived growth factors. Blood Rev 3. 269–276, 1989.
Monaco ME, Gershengorn MC. Subcellular organization of receptor-mediated phosphoinositide turnover. EndoocrineRev 13: 707–718, 1992.
Moodie SA, Willumsen BM, Weber MJ, Wolfman A. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase. Science 260: 1658–1661, 1993.
Moore MS, Blobel G. The GTP binding protein ran/TC4 is required for protein import into the nucleus. Nature 365: 661–663, 1993.
Morii N, Teru-Uchi T, Tominaga T, Rumaci N, Kozaki S, Ushdcubi F, Narumiya S. A Rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation. J Biol Chem 267: 20921–20926, 1992.
Moroi M, Jung SM. Platelet receptors for collagen. Thromb Haemost 78: 439–444, 1997.
Mueller HW, Pritzker CR, Kubik A, Deykin D. Characterization of phospholipase A2 secretion from human platelets. Thromb Res 72: 519–530, 1993.
Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci 18: 343–348, 1993.
Nahas N, Plantavid M, Mauco G, Chap H. Association of phosphatidylinositol kinase and phosphatidylinositol 4-phosphate kinase activities with the human platelets. FEBS Lett 246: 30–34, 1989.
Naka M, Nishkawa M, Adelstein RS, Hidaka H. Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains. Nature 306: 490–492, 1983.
Nakashima S, Tohmatsu T, Hattori H, Okano Y, Nozawa Y. Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets. Biochem Biophys Res Commun 135: 1099–1104, 1986.
Nehr EJ. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80: 249–257, 1995.
Nemoto Y, Namba T, Teru-Uchi T, Ushikubi F, Morii N, Narumiya S. A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein. J Biol Chem 267: 20916–20920, 1992.
Nkholson-Weller A, Spicer DB, Austen KF. Deficiency of the complement regulatory protein, “decay-accelerating factor,” on membranes of granulocytes, monocytes, and platelets in paroxysmal nocturnal hemoglobinuria. N Engl J Med 312: 1091–1097, 1985a.
Nkholson-Weller A, March JP, Rosen CE, Spicer DB, Austen KF. Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system. Blood 65: 1237–1244, 1985b.
Nieuwenhub HK, van Oosterhout JJG, Rozemuller E, van Iwaarden F, Sixma JJ. Studies with amonoclonal antibody against activated platelets: Evidence that a secreted 53,000-molecular weight lysosomelike granule protein is exposed on the surface of activated platelets in the circulation. Blood 70: 838–845, 1987.
Nieuwland R, Wijburg OLC, van Willigen G, Akkerman JWN. α2A adrenergic receptors activate protein kinase C in human platelets via a pertussis toxin-sensitive G-protein. FEBS Lett 339: 79–83, 1994.
Nishida E, Gotoh Y. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biol Sci 18: 128–131, 1993.
Nolte C, Eigenthaler M, Horstrup K, Hönig-Liedl P, Walter U. Synergistic phosphorylation of the focal adhesion-associated vasodilator-stimulated phosphoprotein in intact human platelets in response to cGMP-and cAMP-elevating platelet inhibitors. Biochem Pharmacol 48: 1569–1575, 1994.
Novick PJ, Brennwald P. Friends and family: the role of the rab GTPases in vesicular traffic. Cell 75, 597–602, 1993.
Nunez D, Charriaut-Marlangue C, Barel M, Benvenute J, Frade R. Activation of human platelets through gp140, the C3d/EBV receptor (CR2). Eur J Immunol 17: 515–520, 1987.
Nurden AT, Nurden P. A review of the role of platelet membrane glycoproteins in the platelet-vessel wall interaction. Baillière’s Clinical Haematology 6: 653–690, 1993.
Ohmori T, Kikuchi A, Yamamoto K, Kim K, Taxai Y. Small molecular weight GTP binding proteins in human platelet membranes. Purification and characterization of a novel GTP-binding protein with a molecular weight of 22.000. J Biol Chem 264: 1877–1881, 1989.
Ohmstede C-A, Farell FX, Reep BR, Clemenson KJ, Lapetina EG. Rap2B: a ras-related GTP-binding protein from platelets. Proc Natl Acad Sci USA 87: 6527–6531, 1990.
O’Rourke F, Matthews E, Feinstein MB. Purification and characterization of the human type 1 Ins(l,4,5)P3 receptor from platelets and comparison with receptor subtypes in other normal and transformed blood cells. Biochem J 312: 499–503, 1995.
Packham MA, Nisheawa E, Mustard JF. Response of platelets to tissue injury. Biochem Pharmacol 17: 171–184, 1968.
Painter RG, Prodouz KN, Gaarde W. Isolation of a subpopulation of glycoprotein IIbIIIa from platelet membranes that is bound to membrane actin. J Cell Biol 100: 652–657, 1985.
Palmer RMJ, Ferrige AG, Mocada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524–526, 1987.
Papkoff J, Chen R-H, Blenis J, Forsman J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol Cell Biol 14: 463–472, 1994.
Peerschke EIB, Ghebrehiwet B. Human blood platelets possess specific binding sites for C1q. J Immunol 138: 1537–1541, 1986.
Peerschke EIB, Ghebrehiewet B. Identification and partial characterization of human platelet C1q binding sites. J Immunol 141: 3505–3511, 1988.
Peerschke EIB, Reid KBM, Ghebrehiwet B. Identification of a novel 33-kDa C1q-binding site on human blood platelets. J Immunol 152: 5896–5901, 1994.
Pelech SL, Sanghera JS. MAP kinases: Charting the regulatory pathways. Science 257: 1355–1356, 1992.
Pletscher A. The 5-hydroxytryptamine system of blood platelets: physiology and pathophysiology. Int J Cardiol 14: 177–188, 1987.
Polaris PG, Weber RF, Nevtns B, Didsbury JR, Evans T, Snyderman RJ. Identification of the ral and racl gene products, low molecular mass GTP-binding proteins from human platelets. J Biol Chem 264: 16383–16389, 1989.
Pollock WK, MacIntyre DE. Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium. Biochem J 234: 67–73, 1986.
Prescott SM, Majerus PW. The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets. J Biol Chem 256: 579–582, 1981.
Pribluda V, Rotman A. Dynamics of membrane-cytoskeleton interactions in activated blood platelets. Biochem J 21: 2825–2832, 1982.
Pronin AN, Gautam N. Interaction between G-protein β and γ subunit types is selective. Proc Natl Acad Sci USA 89: 6220–6224, 1992.
Pumglia KM, Lau L-F, Huang C-K, Burroughs S, Feinstein MB. Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochem J 286: 441–449, 1992.
Quinton TM, Dean WL. Cyclic AMP-dependent phosphorylation of the inositol-1.4.5-trisphosphate receptor inhibits Ca2+ release from platelet membranes. Biochem Biophys Commun 184: 893–899; 1992.
Quinton TM, Brown KD, Dean WL. Inositol 1.4.5-trisphosphate-mediated Ca2+ release from platelet internal membranes is regulated by differential phosphorylation. Biochemistry 35: 6865–6871; 1996.
Radomski MW, Palmer RMJ, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 148: 1482–1489, 1987.
Raja S, Avraham S, Avraham H. Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism. J Biol Chem 272: 10941–10947, 1997.
Rasmussen H, Isales CM, Calle R, Throckmorton D, Anderson M, Gasalla-Herraiz J, Mccarthy R. Diacylglycerol production, Ca2+ influx, and protein kinase C activation in sustained cellular responses. Endocrine Rev 16, 649–681, 1995.
Rasmussen UB, Vouret-Craviari V, Jallat S, Schlesinger Y, Pagès G, Pavirani A, Lecocq J-P, Pousségur J, van Obberghen-Schilling E. CDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett 288: 123–128, 1991.
Ray K, Kunsch C, Bonner LM, Robishaw JD. Isolation of cDNA clones encoding eight different human G protein γ subunits, including three novel forms designated the γ4, γ 10 and γ 11 subunits. J Biol Chem 270: 21765–21771, 1995.
Reinhard M, Halbrügge M, Scheer U, Wiegand C, Jockusch BM, Walter U. The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. EMBO J 11: 2063–2070, 1992.
Ridley A, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesion and actin stress fibres in response to growth factors. Cell 70: 389–399, 1992a.
Ridley AJ, Paterson HF, Johnston CL, Diekman D, Hall A. The small GTP binding protein rac regulates growth-factor-induced membrane ruffling. Cell 70: 401–410, 1992b.
Rink TJ, Sage SO. Calcium signalling in human platelets. Annu Rev Physiol 52: 431–349, 1990.
Rittenhouse SE, Horne WC. Ionomycin can elevate intraplatelet Ca2+ and activate phospholipase A2 without activating phospholipase C. Biochem Biophys Res Commun 123: 393–397, 1984.
Ritenhouse-Simmons SE. Production of diglyceride from phosphatidylinositol in activated platelets. J Clin Invest 63. 580–587, 1979.
Rittenhouse-Simmons S. Differential activation of platelet phospholipases by thrombin and ionophore A23187. J Biol Chem 256: 4153–4155, 1981.
Romano M, Serhan CN. Lipoxin generation by permeabilized human platelet. Biochemistry 31: 8269–8277, 1992.
Rosenberg S, Stracker A, Lucas RC. Isolation and characterization of actin and actin-binding protein from human platelets. J Cell Biol 91: 201–211, 1981.
Rosenfeld SI, Ryan DH, Looney RJ, Anderson CL, Abraham GN, Leddy JP. Human Fcγ receptors: stable inter-donor variation in quantitative expression on platelets correlates with functional responses. J Immunology 138: 2869–2873, 1987.
Ross EM. Protein modification: Palmitoylation in G-protein signalling pathways. Curr Biol 5: 107–109, 1995.
Ruan C, Tobelem G, McMichael AJ, Drouet L, Legrand Y, Degos L, Kieffer N, Lee H, Caen JP. Monoclonal antibody to human glycoprotein I: II Effects on human platelet function. Br J Haematol 49: 511–519, 1981.
Ruggeri ZM, Zimmerman TS. von Willebrand factor and von Willebrand disease. Blood 70: 895–904, 1987.
Ryningen A, Holmsen H. Thrombin per se does not induce tyrosine phosphorylation in human platelets as judged by Western blotting, while collagen does: the significance of synergistic, autocrine stimulation. Biochem Biophys Res Commun. In Press, 1998.
Salama SE, Haslam RJ. Characterization of the protein kinase activities of human platelet supernatant and particulate fractions. Biochem J 218: 285–294, 1984.
Saltzman AG, Morse B, Whitman MM, Ivanschenko Y, Jaje M, Felder S. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochem Biophys Res Commun 181: 1469–1478, 1991.
Salzman EW. Interrelation of prostaglandin endoperoxide PGG2 and cyclic 3’, 5’ adenosine monophosphate in human blood platelets. Biochim Biophys Acta 499: 48–60, 1977.
Saussy DL Jr Mais DE, Burch RM, Halushka PV. Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes, J Biol Chem 261: 3025–3029, 1986.
Schafer AI, Crawford DD, Gimbrone MA. Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells. J Clin Invest. 73: 1105–1112, 1984.
Schaller MD, Otey CA, Hildebrand JD, Parsons JT. Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domains. J Cell Biol 130: 1181–1187, 1995.
Schlaepfer DD, Hanks SK, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372: 786–791, 1994.
Schmaier AH, Smith PM, Colman RW. Platelet C1 inhibitor. A secreted alpha-granule protein. J Clin Invest 75: 242–250, 1985.
Serafini T, Orci L, Amherdt M, Brunner M, Kahn R, Rothman JE. ADP-ribosylation factor is a subunit of the coat of golgi-derived COP-coated vesicles: a novel role for a GTP binding protein. Cell 67: 239–253, 1991.
Seth SB, Colman RW. Regulatory and catalytic domains of platelet cAMP phosphodiesterases: target for drug design. Semin Hematol 32: 110–119, 1995.
Seya T, Turner J, Atxinson JP. Purification and characterization of a membrane protein (gp45-70) which is a cofactor for cleavage of C3b and C4b. J Exp Med 163: 837–855, 1986.
Shattil S J, Hoxie JA, Cunningham M, Brass LF. Changes in the platelet membrane glycoprotein IIb/IIIa complex during platelet activation. J Biol Chem 260: 11107–11114, 1985.
Shattil SJ, Brass LF. Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem 262: 992–999, 1987.
Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signalling through integrin and agonist receptors. J Biol Chem 269: 14738–14745, 1994a.
Shattil SJ, Ginsberg MH, Brugge JS. Adhesive signaling in platelets. Curr Opin Cell Biol 6: 695–704, 1994b.
Shaw G. Identification of novel pleckstrin homology (PH) domains provides a hypothesis for PH domain function. Biochem Biophys Res Commun 195: 1145–1151, 1993.
Shuman MA, Greenberg CS. “Platelet regulation of thrombus formation.” In: Biochemistry of Platelets. Eds. DR Phillips and MA Shuman. Academic (Orlando), pp 319, 1986.
Siegl AM, Smith JB, Silver MJ. Specific binding sites for prostaglandin D2 on human platelets. Biochem Biophys Res Commun 90: 291–296, 1979.
Siess W. Molecular mechanisms of platelet activation. Physiol Rev 69: 58–178, 1989.
Siess W, Lapetina EG. Functional relationship between cyclic AMP-dependent protein phosphorylation and platelet inhibition. Biochem J 271: 815–819; 1990.
Siffert W, Fox G, Munckenhoff K, Scheid P. Thrombin stimulates Na+/H+ exchange across the human platelet plasma membrane. FEBS Lett 172: 272–274, 1984.
Siffert W, Siffert G, Scheid P. Activation of Na+/H+ exchange in human platelets stimulated by thrombin and aphorbol ester. Biochem J 241: 301–303, 1987.
Siffert W. Regulation of platelet function by sodium-hydrogen exchange. Cardiovasc Res 29: 160–166, 1995.
Simon MI, Strathmann MP, Gautam N. Diversity of G proteins in signal transduction. Science 252: 802–808, 1991.
Sims PJ, Wiedmer T. Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca2+-dependent exocytotic elimination of C5b-9 pores. Blood 68: 556–561, 1986.
Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem 263: 18205–18212, 1988.
Sims PJ, Rollins SA, Wiedmer T. Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex. J Biol Chem 264: 19228–19235, 1989.
Smith JB, Mills DCB. Inhibition of adenosine 3’,5’ cyclic monophosphate phosphodiesterase. Biochem J 120: 20, 1970.
Smrcka AV, Sternweis PC. Regulation of purified subtypes of phosphatidylinositol-specific phospholipase Cβ by G protein α and βγ subunits. J Biol Chem 268: 9667–9674, 1993.
Steen VM, Holmsen H. Current aspects on human platelet activation and responses. Eur J Haematol 38: 383–399, 1987.
Steen VM, Tysnes OB, Holmsen H. Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets. Biochem J 263: 621–624, 1989.
Steen VM, Aarbakke G, Holmsen H. The platelet-stimulating effect of adrenaline through alpha 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist Evidence that adrenaline per se does not induce human platelet activation in vitro. Thromb Haemost 70: 506–513, 1993.
Stenberg PE, Shuman MA, Levine SP, Bainton DF. Redistribution of alpha-granules and their contents in thrombin-stimulated platelets. J Cell Biol 98: 748–760, 1984
Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF. A platelet alpha-granule membrane protein (GMP140) is expressed on the plasma membrane after activation. J Cell Biol 101: 880–886, 1985.
Stokoe D, MacDonald SG, Cadwallader K, Symons M, Hancock JF. Activation of Raf as a result of recruitment to the plasma membrane. Science 264: 1463–1467, 1994.
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebrobck B, Dhand R, Nurnberg B, Gershik P, Seedorf K, Hsuan JJ, Waterfield MD. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269: 690–693, 1995.
Suga K, Kambayashi J, Kawasaki T, Sakon M, Mori T. Phosphorylation of phosphoinositides in human platelets. Thromb Res 44: 155–163, 1986.
Suzuki S, Argraves WS, Arai H, Languino LF, Pierschbacher MD, Ruoslathi E. Aminoacid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs. J Biol Chem 262: 14050–14058, 1987.
Suzuki T, Banno Y, Nozawa Y. Partial purification and characterization of two forms of phosphatidylinositol 4-phosphate 5-kinase from human platelet membrane. Thromb Res 64: 45–56, 1991.
Suzuki T, Nakashima S, Nozawa Y. Inhibition of phosphatidylinositol 4-phosphate 5-kinase by cyclic AMP in human platelets. Platelets 5: 258–265, 1994.
Takahara K, Murray R, Fitzgerald GA, Fitzgerald DJ. The response to thromboxane A2 analogues in human platelets. J Biol Chem 265: 6836–6844, 1990.
Tarai Y, Sasaki T, Tanaka K, Nakanishi H. Rho as a regulator of the cytoskeleton. Trends In Biochem Sci 20: 227–230, 1995.
Tao J, Johansson JS, Haynes DH. Stimulation of dense tubular Ca2+ uptake in human platelets by cAMP. Biochim Biophys Acta 1105: 29–39, 1992.
Tans G, Rosing J, Thomassen MC, Heeb MJ, Zwaal RF, Griffin JH. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood 77, 2641–2648, 1991.
Tedder TF, Steeber DA, Chen A, Engel P. The selectins: vascular adhesion molecules. FASEB J 9: 866–873, 1995.
Teo M, Manser E, Lim L. Identification and molecular cloning of a p21cdc42/tac1-activated serin/threonine kinase that is rapidly activated by thrombin in platelets. J Biol Chem 270: 26690–26697, 1995.
Thomason PA, James SR, Casey PJ, Downes CP. A G-protein βγ-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J Biol Chem 269: 16525–16528, 1994.
Tolias KF, Cantley LC, Carpenter CL. Rho family GTPases bind to phosphoinositide kinases. J Biol Chem 270: 17656–17659, 1995.
Torti M, Singaglia F, Ramascei G, Balduini C. Platelet glycoprotein IIb-IIIa is associated with 21-kDa GTP-binding protein. Biochim Biophys Acta 1070: 20–26, 1991.
Torti M, Lapetina EG. Role of rap1B and p21ras GTPase activating protein in the regulation of phospholipase C-g1 in human platelets. Proc Natl Acad Sci USA 89: 7796–77800, 1992.
Torti M, Lapetina EG. Structure and function of rap proteins in human platelets. Thromb Haemost 71: 533–543, 1994.
Touhara K, Inglese J, Pitcher JA, Shaw G, Lefkowitz RJ. Binding of G protein βγ-subunits to pleckstrin homology domains. J Biol Chem 269: 10217–10220, 1994.
Touhara K, Hawes BE, van Biesen T, Lefkowitz RJ. G protein βγ subunits stimulate phosphorylation of the She adapter protein. Proc Natl Acad Sci USA 92: 9284–9287, 1995.
Tracy PB, Mann KG. #x201C;A model for assembly of coagulation factor complexes on cell surfaces: Prothrombin activation on platelets.” In Biochemistry of Platelets. Eds: DR Phillips and MA Shuman, Academic (Orlando), pp 296, 1986.
Tschopp J, Jenne DE, Herto S, Preissner KT, Morgenstern H, Sapino A-E, French L. Human megakaryocytes express clusterin and package it without apolipoprotein A-1 into α-granules. Blood 82: 118–125, 1993.
Tsukuda M, Asaoka Y, Sekiguchi K, Kikkawa U, Nisheuka Y. Properties of protein kinase C subspecies in human platelets. Biochem Biophys Res Commun 155: 1387–1395, 1988.
Turitto VT, Weiss HJ, Baumbartner HS. Decreased platelet adhesion on vessel segments in von Willebrand’s disease: A defect in initial platelet attachment. J Lab Clin Med 102: 551–564, 1983.
Turitto VT, Weiss HJ, Zimmerman TS, Sussman II. Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion. Blood 65: 823–831, 1985.
Tyers M, Rachubinski RA, Stewart MI, Varrichio AM, Shorr RG, Haslam RJ, Harley CB. Molecular cloning and expression of the major protein kinase C substrate of platelets. Nature 333: 470–473, 1988.
Tysnes OB, Verhoeven AJM, Aarbakke GM, Holmsen H. Phosphoinositide metabolism in resting and thrombin-stimulated human platelets. FEBS Lett 218: 68–72, 1987.
Tysnes OB, Verhoeven AJM, Holmsen H. Rates of production and consumption of phosphatidic acid upon thrombin stimulation of human platelets. Eur J Biochem 174: 75–79, 1988.
Tysnes OB, Steen VM, Frølich KW, Holmsen H. Evidence that chlorpromazine and prostaglandin E1 but not neomycin interfere with the inositol phospholipid metabolism intact human platelets. FEBS Lett 264: 33–36, 1990.
Ueda N, Iniguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG. G protein βγ subunits. J Biol Chem 269: 4388–4395, 1994.
van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ. Receptor-tyrosine-kinase-and Gβγ-mediated MAP kinase activation by a common signalling pathway. Nature 376: 781–784, 1995.
van Corven EJ, Hordijk PL, Medema RH, Bos JL, Moolenaar WH. Pertussis toxin-sensitive activation of p21src by G protein-coupled receptor agonists in fibroblasts. Proc Natl Acad Sci USA 90: 1257–1261, 1993.
Vanderwei M, Lum DS, Haslam RJ. Vasopressin inhibits the adenylate cyclase activity of human platelet particulate fraction through V1-receptors. FEBS Lett 164: 340–344, 1983.
Vane JR, Moncada S. Prostacyclin. Ciba Found Symp 71: 79–97, 1980.
van Willigen G, Akkerman JWN. Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIb/IIIa complex of human platelets. Biochem J 273: 115–121, 1991.
van Willigen G, Donath J, Lapetina EG, Akkerman JWN. Identification of α-subunits of trimeric GTP-binding proteins in human platelets by RT-PCR. Biochem Biophys Res Commun 214: 254–262, 1995.
Vassbotn FS, Havnen OK, Heldin C-H, Holmsen H. Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor α-receptor. J Biol Chem 269: 13874–13879, 1994.
Verhoeven AJM, Mommersteg ME, Akkerman JWN. Quantification of energy consumption in platelets during thrombin-induced aggregation and secretion: tight coupling between platelet responses and the increment in energy consumption. Biochem J 221: 777–787, 1984.
Verhoeven AJM, Tysnes OB, Aarbakke GM, Cook CA, Holmsen H. Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets. Eur J Biochem 166: 3–9, 1987.
Vicers JD, Mustard JF. The phosphoinositides exist in multiple pools in rabbit platelets. Biochem J 238: 411–417, 1986.
Vir DP, Fearon DT. Cellular distribution of complement receptor type 4 (CR4): expression on human platelets. J Immunol 138: 254–258, 1987.
Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL. Gα13 stimulates Na-H exchange. J Biol Chem 269: 4721–4724, 1994.
Vut KH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 1057–1068, 1991.
Wagner DD, Marder VJ. Biosynthesis of von Willebrand protein by human endothelial cells: Processing steps and their intracellular localization. J Cell Biol 99: 2123–2130, 1984.
Waldmann R, Bauer S, Göbel C, Hofmann F, Jacobs KH, Walter U. Demonstration of cGMP-dependent protein kinase and cGMP-dependent phosphorylation in cell-free extracts of platelets. Eur J Biochem 158: 203–210, 1986.
Waldmann R, Nieberding M, Walter U. Vasodilator-stimulated protein phosphorylation in platelet is mediated by cAMP-and cGMP-dependent protein kinases. EurJ Biochem 167: 441–448, 1987.
Wang F, Nak UP, Ehrlich YH, Freyberg Z, Osada S, Ohno S, Kuroki T, Suzuki K, Kornecki E. A new protein kinase C, nPKCη‘, and nPKCθ are expressed in human platelets: Involvement of nPKCη ‘and nPKCθ in signal transduction stimulated by PAF Biochem Biophys Res Commun 191: 240–246, 1993.
Wang J, Auger KR, Jarvis L, Shi Y, Roberts TM. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 270: 12774–12780, 1995.
Ware JA, Heistad DD. Platelet-endothelium interactions. N Engl J Med 328: 628–635, 1993.
Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. Palmitoylation is required for signalling functions and membrane attachment of Gqα and Gsα. J Biol Chem 268: 25001–25008, 1993.
Wedegaertner PB, Bourne HR. Activation and depalmitoylation of Gsα. Cell 70: 1063–1070, 1995.
Weiss HJ, Tschopp TB, Baumgariner HR, Sussman II, Johnson MM, Egan JJ. Decreased adhesion of giant (Bernard-Soulier) platelets to subendothelium. Am J Med 57: 920–925, 1974.
Welch GN, Upchurch GR, Loscalzo J. Nitric oxide as a vascular modulator. Blood Rev 9: 262–269, 1995.
White JG. A search for the platelet secretory pathway using electron-dense tracers. Am J Pathol 58: 31–49, 1970.
White JG. Electron microscopic studies of platelet secretion. Prog Hemost Thromb 2: 49, 1974.
White JG, Krumwiede M. Further studies of the secretory pathway in thrombin-stimulated human platelets. Blood 69: 1196–1203, 1987a.
White JG. Views at the platelet cytoskeleton at rest and at work. Ann NY Acad Sci 509: 156–176, 1987b.
White JG. “Platelet Ultrastructure.” In. Haemostasis and Thrombosis, 2nd. ed. Eds: AL Bloom & DP Thomas. Churhill Livingstone (UK) pp 20–46, 1987c.
Wiedmer T, Sims PJ. Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential. J Biol Chem 260: 8014–8019, 1985.
Wiedmer T, Esmon CT, Sims PJ. Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase. Blood 68: 875–880, 1986a.
Wiedmer T, Esmon CT, Sims PJ. On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity. J Biol Chem 261: 14587–14592, 1986b.
Wiedmer T, Ando B, Sims PJ. Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases. J Biol Chem 262: 13674–13681, 1987.
Witte LD, Kaplan KL, Nossel HL, Lages BA, Weiss HJ, Goodman DS. studies of the release from human platelets of the growth factor for cultured human smooth muscle cells. Circ Res 42: 402–409, 1978.
Wong PY, Westlund P, Hamberg M. 15-lipoxygenase in human platelets. J Biol Chem 260: 9162–9171, 1985.
Wright JH. The origin and nature of blood platelets. Boston Med surg J 154: 643, 1906.
Wright JH. The histogenesis of the blood platelets. J Morphol 21: 203, 1910.
Wu XW, Lian EC. Binding properties and inhibition of platelet aggregation by a monoclonal antibody to CD31 (PECAM-1). Arterioscler Thromb Vasc Biol 17: 3154–3158, 1997.
Yada Y, Nagao S, Okano Y, Nozawa Y. Inhibition by cyclic AMP of guanine nucleotide-induced activation of phosphoinositide-specific phospholipase C in human platelets. FEBS-Lett 242: 368–372, 1989.
Yamanishi J, Kawahara Y, Fukuzakih L. Effect of cyclic AMP on cytoplasmic free calcium in human platelets stimulated by thrombin: direct measurement with quin2. Thromb Res 32: 183–188, 1983.
Yano Y, Kambayashi J, Shiba E, Sakon M, Oiki E, Fukuda K, Kawasaki T, Mori T. The role of protein phosphorylation and cytoskeletal reorganization in microparticle formation from the platelet plasma membrane. Biochem J 299: 303–308, 1994.
Yezs, Baltimore D. Binding of Vav to Grb2 through dimerization of Src homology 3 domains. Proc Natl Acad Sci USA 91: 12629–12633, 1994.
Yoon HS, Hajduk PJ, Petrus AM, Olejniczak ET, Meadows RP, Fesik SW. Solution structure of a pleckstrin-homology domain. Nature 369: 672–675, 1994.
Yosmda K, Dubyak K, Nachmas VT. Rapid effects on phorbol ester on platelet shape change, cytoskeleton and calcium transient. FEBS Lett 206: 273–278, 1986.
Zavoico GB, Feinstein MB. Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: Antagonism between stimulators and inhibitors of adenylate cyclase. Biochem Biophys Res Commun 120: 579–585, 1984.
Zhang J, King WG, Dillon S, Hall A, Feig L, Rittenhouse SE. Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho. J Biol Chem 268: 22251–22254, 1993.
Zhang J, Benovic JL, Sugai M, Wetzker R, Gout I, Rittenhouse SE. Sequestration of a G-protein βγ subunit or ADP-ribosylation of rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases. J Biol Chem 270: 6589–6594, 1995.
Zhang J, Shattil SJ, Cunningham MC, Rittenhouse SE. Phosphoinositide 3-kinase γ and p85/phosphoinositide 3-kinase in platelets. J Biol Chem 271: 6265–5272, 1996.
Zigmond SH. Signal transduction and actin organization. Curr Opin Cell Biol 8: 66–73, 1996.
Zhu Y, O’Neill S, Saklatvala J, Tassi L, Mendelsohn ME. Phosphorylated HSP27 associates with the activation-dependent cytoskeleton in human platelets. Blood 84: 3715–3723, 1994.
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Ryningen, A., Holmsen, H. (1999). Biochemistry of Platelet Activation. In: Rao, G.H.R. (eds) Handbook of Platelet Physiology and Pharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5049-5_9
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